Trombital Fort Tab n / a film about 150mg + 30.39mg 30 pc

$4.58

Trombital Fort Tab n / a film about 150mg + 30.39mg 30 pc

Quantity:

SKU: 1795058721 Categories: , , Tags: ,

Description

Composition
Active substance:
1 tablet contains: Acetylsalicylic acid – 150,00 mg, magnesium hydroxide – 30.39 mg.
Excipients:
Microcrystalline Cellulose – 24.15 mg maize starch – 19.00 mg potato starch – 4.00 mg magnesium stearate – 0.30 mg.
Coating: Hypromellose (hydroxypropyl methylcellulose 15 cps) – 1.20 mg macrogol (polyglycol 4000) – 0.24 mg talc – 0.72 mg.
Description:
Round biconvex tablets, film-coated white or nearly white, in cross-section core of a white or nearly white.
Product form:
Tablets, film-coated, 150 mg + 30.39 mg.
30 or 100 tablets in banks dark (amber) glass, sealed with screw cap, white (polyethylene) with a removable capsule mounted silica gel ring and providing a first control opening. 1 can dark (amber) glass together with instructions for use placed in a pile of cardboard.
Contraindications
• Increased sensitivity to acetylsalicylic acid formulation excipients and other nonsteroidal anti-inflammatory drugs (NSAIDs); • bleeding in the brain; • a tendency to bleeding (vitamin K deficiency, thrombocytopenia, hemorrhagic diathesis); • erosive and ulcerative lesions of the gastrointestinal tract (exacerbation); • gastrointestinal bleeding; • asthma, induced by intake of salicylates or other NSAIDs; • combination of asthma, recurrent nasal polyposis and paranasal sinuses with intolerance to acetylsalicylic acid; • simultaneous reception of methotrexate at a dose of 15 mg per week or more; • pregnancy (I and III trimester); • lactation; • lack of glucose-6-phosphate dehydrogenase; • severe renal failure (creatinine clearance (CC) of less than 30 ml / min); • severe liver failure (class B and C Child-Pugh); • chronic heart failure III and IV NYHA functional class classification; • Children up to age 18 years.
Carefully
Gout, hyperuricemia, since acetylsalicylic acid in small doses, reduces the excretion of uric acid.
With a history of ulcerative lesions of the gastrointestinal tract or gastrointestinal bleeding.
When liver failure (class A on a scale Child-Pugh).
In renal failure (creatinine clearance of more than 30 ml / min).
In bronchial asthma, chronic respiratory diseases, hay fever, nasal polyposis, allergic conditions, drug allergies.
In diabetes.
Elderly patients.
In the II trimester of pregnancy.
When the intended surgical procedure (including minor, e.g., tooth extraction) since acetylsalicylic acid can cause bleeding propensity to develop within a few days after ingestion.
When simultaneous administration with the following drugs (., See “Interaction with other drugs»): • with methotrexate at a dose less than 15 mg per week; • with anticoagulants, thrombolytic or antiplatelet agents; • with NSAIDs and salicylic acid derivatives in high doses; • with digoxin; • with hypoglycemic agents for oral use (sulfonylurea derivatives) and insulin; • with valproic acid; • alcohol (alcohol in particular); • with a selective serotonin reuptake inhibitor; • ibuprofen, • with narcotic analgesics, • with sulfonamides (including co-trimoxazole), • carbonic anhydrase inhibitors (acetazolamide), • with lithium, • with systemic corticosteroids.
Dosage
150 mg + 30.39 mg
Indications
Primary prevention of cardiovascular diseases such as thrombosis and congestive heart failure in the presence of risk factors (e.g., diabetes, hyperlipidemia, hypertension, obesity, smoking, old age).
Prevention of cardiovascular disease: myocardial reinfarction, vascular thrombosis.
Prevention of thromboembolic events after surgical interventions on vessels (e.g., coronary artery bypass graft, percutaneous transluminal coronary angioplasty, etc.).
Unstable angina (including suspicion of acute myocardial infarction).
Interaction with other drugs
With simultaneous use of acetylsalicylic acid increases the effect of the following medicaments: – methotrexate by reducing renal clearance and displace it from connection with proteins, a combination of acetylsalicylic acid with MTX accompanied by increased incidence of side effects of hematopoiesis; – narcotic analgesics, and other NSAIDs; – heparin and indirect anticoagulants due to abnormalities of platelet function and displacement of anticoagulants due to plasma protein; – thrombolytic, antiplatelet and anticoagulant drugs (ticlopidine); – digoxin due to the decrease in its renal excretion; – hypoglycemic agents for oral use (sulfonylurea derivatives) and insulin due hypoglycemic properties of the acetylsalicylic acid in high doses and displacement of sulfonylurea derivatives connection with plasma proteins; – valproic acid due to displacement from its connection with blood plasma proteins.
Concomitant use of aspirin ibuprofen reduces the cardioprotective effects of acetylsalicylic acid.
The combination of aspirin with anticoagulant, thrombolytic and antiplatelet agents associated with an increased risk of bleeding.
Simultaneous treatment with acetylsalicylic acid increases the concentration of a barbiturate and lithium salts in the blood plasma.
Leveraging the elimination of salicylates, systemic steroids weaken their effect.
Glucocorticosteroids, ethanol and etanolsoderzhaschie medicines contribute to a negative effect on the mucous membrane of the gastrointestinal tract, and increase the risk of gastrointestinal bleeding.
When concomitantly with acetylsalicylic acid and ethanol has been increasing the toxic effect of ethanol on the central nervous system.
Acetylsalicylic acid reduces the effect of uricosuric drugs – benzbromaron, probenicid (reduction urikozuricheskogo effect due to competitive suppressing renal tubular excretion of uric acid), angiotensin converting enzyme inhibitors (marked dose-dependent decrease in glomerular filtration rate by inhibiting prostaglandins possessing vasodilating action, and accordingly attenuation of the hypotensive action), a diuretic (for combined use with atsetilsalitsil oic acid in high doses, there is a decrease in glomerular filtration rate by reducing the synthesis of prostaglandins in the kidneys).
Antacids colestyramine and reduce the absorption of acetylsalicylic acid.
If you apply the above or any other medicines (including OTC), before use of the drug Trombital Forte consult your doctor.
Overdose
May occur after a single dose at high dose or long-term use of the drug. If a single dose of acetylsalicylic acid is less than 150 mg / kg acute poisoning find easy, 150-300 mg / kg – moderate, and when using higher doses – heavy.
Overdose symptoms of mild to moderate severity: vertigo, tinnitus, hearing loss, blurred vision, sweating, nausea, vomiting, headache, confusion, tachypnea, hyperventilation, respiratory alkalosis.
Treatment: provocation vomiting, repeated administration of activated charcoal, forced alkaline diuresis, restoring the balance of water and electrolyte and acid-base status.
Overdose symptoms of moderate to severe: • respiratory alkalosis with compensatory metabolic acidosis; • hyperpyrexia (extremely high body temperature); • respiratory disorders: hyperventilation, non-cardiogenic pulmonary edema, respiratory depression, apnea; • disorders of the cardiovascular system: cardiac arrhythmias, lowering blood pressure, depression of cardiac activity, collapse; • violations of water-electrolyte balance: dehydration, renal failure by oliguria until the development of renal failure, characterized by hypokalemia, hypernatremia, hyponatremia; • impaired glucose metabolism: hyperglycemia, hypoglycemia (especially in children), ketoacidosis; • ringing in the ears, deafness; • gastrointestinal bleeding; • haematological disorders: inhibition of platelet aggregation to coagulopathy, prolonged prothrombin time, hypoprothrombinemia; • neurological disorders: toxic encephalopathy and depression of the central nervous system (drowsiness, confusion, coma, convulsions).
Treatment: Immediately hospitalization in specialized units for emergency therapy – gastric lavage, repeated administration of activated charcoal and laxatives alkalization urine (shown in the level of salicylates higher than 500 mg / l, provides an intravenous infusion of sodium carbonate – 88 mEq in 1 L of 5% glucose solution at a rate of 10-15 ml / kg / h), the restoration of circulating blood volume and the induction of diuresis (achieved by the introduction of sodium hydrogen carbonate at the same dose and dilution was repeated 2-3 times); it should be borne in mind that an intense infusion fluid of elderly patients may lead to pulmonary edema. It is not recommended for use atsetozolamida alkalinization urine (acidemia may cause toxic effects and enhance salicylates). When conducting alkali diuresis necessary to achieve pH values ​​of between 7.5 and 8. Hemodialysis is indicated in salicylate levels in the blood plasma of more than 1000 mg / l, and in patients with chronic poisoning – 500 mg / l or less when indicated (refractory acidosis, progressive deterioration, severe damage to the central nervous system, pulmonary edema and renal insufficiency). It is shown in pulmonary edema artificial ventilation with a mixture enriched in oxygen at a positive pressure mode at the end of the exhalation; for treating brain edema used hyperventilation and osmotic diuresis.
The greatest risk of chronic intoxication observed in elderly patients when administered within a few days more than 100 mg / kg / day. Children and elderly patients initial symptoms salitsilizma (nausea, vomiting, ringing in the ears, blurred vision, dizziness, headache, malaise) are not always visible, so it is advisable to periodically determine the content of salicylates in blood plasma.
pharmachologic effect
Pharmacological group:
Antiplatelet agent.
Pharmacodynamics:
Decreases aggregation, platelet adhesion and thrombus formation by inhibiting thromboxane A2 synthesis in platelets. Antiplatelet effect persists for 7 days after a single dose (more pronounced in males than in females).
Aspirin reduces mortality and risk of myocardial infarction, unstable angina, is effective in primary prevention of diseases of the cardiovascular system, particularly myocardial infarction in men over 40 years, and for secondary prevention of myocardial infarction.
Inhibits the synthesis of prothrombin in the liver and increases the prothrombin time. It enhances fibrinolytic activity of blood plasma and reduces the concentration of vitamin-K-dependent coagulation factors (II, VII, IX, X). Increases the risk of hemorrhagic complications during surgery, increases the risk of bleeding during anticoagulant therapy.
Acetylsalicylic acid in high doses also has anti-inflammatory, analgesic, antipyretic effect.
In high doses, acetylsalicylic acid stimulates excretion of uric acid (violating its reabsorption in the renal tubules).
Blockade of COX-1 in the gastric mucosa leads to inhibition of gastroprotective prostaglandins, which may lead to ulceration of the mucosa and subsequent bleeding.
Magnesium hydroxide, part of the drug Trombital Forte, protects the mucosa of the gastrointestinal tract from the effects of acetylsalicylic acid.
Pharmacokinetics:
Acetylsalicylic acid is absorbed from the gastrointestinal tract almost completely. The half-life of acetylsalicylic acid is about 15 minutes, because involving enzymes acetylsalicylic acid is rapidly hydrolyzed to salicylic acid in the intestine, liver and blood plasma. The half-life of salicylic acid is about 3 hours, but it may increase considerably with a simultaneous administration of large doses of aspirin (more than 3.0 g) as a result of saturation of enzyme systems.
Bioavailability of acetylsalicylic acid is 70%, but this value greatly fluctuates as acetylsalicylic acid undergoes first-pass hydrolysis (mucous membrane of the gastrointestinal tract, liver) in the salicylic acid by the action of enzymes. Bioavailability of salicylic acid is 80-100%.
The doses used the magnesium hydroxide does not affect the bioavailability of acetylsalicylic acid.
Pregnancy and breast-feeding
Forte Trombital drug is contraindicated for use in I and III trimester of pregnancy, as teratogenic – when used in the I trimester of pregnancy leads to fetal cleavage upper palate, in the III trimester – cause inhibition of labor activity (inhibition of prostaglandin synthesis), premature closure of the ductus arteriosus in the fetus, hyperplasia, pulmonary vascular and hypertension in the pulmonary circulation.
Acceptance of the drug in the II trimester is possible only if the potential benefit to the mother outweighs the risk to the fetus.
Acetylsalicylic acid and its metabolites into breast milk. At the time of treatment should stop breastfeeding.
Conditions of supply of pharmacies
Without recipe.
side effects
The following adverse events are distributed over occurrence frequency according to the following gradation: very often (with a frequency of 1/10), often (with a frequency not less than 1/100 but less than 1.10), infrequently (at a frequency of at least 1 / 1000 but less than 1/100), rarely (with a frequency of not less than 1/10000 and less than 1/1000), very rare (with a frequency of less than 1/10000), including isolated reports.
From the blood and lymphatic system: very often – increased bleeding (hematoma, nosebleeds, bleeding gums, bleeding from the urinary tract); rarely – anemia; very rarely – hypoprothrombinemia, thrombocytopenia, neutropenia, aplastic anemia, eosinophilia, agranulocytosis; unknown frequency – leukopenia. There are reports of serious cases of bleeding, which include gastrointestinal bleeding and bleeding in the brain (especially in patients with hypertension who have not reached the target blood pressure numbers and / or receiving concomitant therapy with anticoagulant drugs), which in some cases may be of life-threatening character. Bleeding can lead to acute or chronic posthemorrhagic / iron deficiency anemia (e.g., flush due to bleeding) with relevant clinical and laboratory signs and symptoms (fatigue, pallor, hypoperfusion). There are reports of hemolysis and hemolytic anemia in patients with severe glucose-6-phosphate dehydrogenase deficiency.
Allergic reactions: often – urticaria, angioedema; infrequently – anaphylactic reactions including angioneurotic edema; unknown frequency – skin rash, pruritus, rhinitis, swelling of the nasal mucosa, cardio-respiratory distress syndrome, and severe reactions, including anaphylactic shock.
From the nervous system: often – headache, insomnia; rarely – dizziness, drowsiness; rarely – ringing in the ears, intracerebral hemorrhage; unknown frequency – hearing loss, which can be a sign of overdosing (see “Overdose”.).
The respiratory system, thorax and mediastinum: often – bronchospasm.
Gastro-intestinal tract: often – heartburn; often – nausea, vomiting; rarely – pain in the abdomen, the mucous membrane of a stomach ulcer and duodenal ulcer, including perforated (rarely), gastrointestinal bleeding; rarely – increased activity of “liver” enzymes; very rarely – stomatitis, esophagitis, erosive lesions of the upper gastrointestinal tract strictures, irritable bowel syndrome, colitis; unknown frequency – loss of appetite, diarrhea.
From the urinary system: unknown frequency – renal dysfunction and acute renal failure.
If you have marked side effects listed in the instructions, or they are compounded, or if you notice any other side effects not mentioned in the instructions, tell your doctor.
special instructions
The drug should be applied by a doctor.
Tablets drug Trombital Forte film-coated, have no risks and are not intended to divide, however if reduction physician recommended daily dose of acetylsalicylic acid and 75 mg, it is required to switch to the reception of another medicament comprising 75 mg of acetylsalicylic acid in one tablet.
Acetylsalicylic acid may provoke bronchospasm and also cause bronchial asthma and other hypersensitivity reactions. Risk factors are the availability of a history of asthma, hay fever, nasal polyposis, chronic diseases of the respiratory system as well as of allergic reactions to other drugs (e.g., skin reactions, pruritus, urticaria).
Ацетилсалициловая кислота может вызывать кровотечения различной степени выраженности во время и после хирургических вмешательств. За несколько дней до планируемого хирургического вмешательства должен быть оценен риск развития кровотечения по сравнению с риском развития ишемических осложнений у пациентов, принимающих низкие дозы ацетилсалициловой кислоты. Если риск кровотечения значительный, прием ацетилсалициловой кислоты должен быть временно прекращен.
Сочетание ацетилсалициловой кислоты с антикоагулянтами, тромболитиками и антитромбоцитарными препаратами сопровождается повышенным риском развития кровотечений.
Ацетилсалициловая кислота в низких дозах может спровоцировать развитие подагры у предрасположенных пациентов (имеющих сниженную экскрецию мочевой кислоты).
Сочетание ацетилсалициловой кислоты с метотрексатом сопровождается повышенной частотой развития побочных эффектов со стороны органов кроветворения.
Высокие дозы ацетилсалициловой кислоты оказывают гипогликемический эффект, что необходимо иметь в виду при назначении ее пациентам с сахарным диабетом, получающим гипогликемические средства для приема внутрь и инсулин.
При сочетанном применении системных глюкокортикостероидов и салицилатов следует помнить, что во время лечения концентрация салицилатов в крови снижена, а после отмены системных глюкокортикостероидов возможна передозировка салицилатов.
Не рекомендуется сочетание ацетилсалициловой кислоты с ибупрофеном у пациентов с повышенным риском сердечно-сосудистых заболеваний: при одновременном применении с ибупрофеном отмечается уменьшение антиагрегантного действия ацетилсалициловой кислоты в дозах до 300 мг, что приводит к снижению кардиопротективных эффектов ацетилсалициловой кислоты.
Повышение дозы ацетилсалициловой кислоты свыше терапевтических доз сопряжено с риском желудочно-кишечного кровотечения.
При длительном приеме низких доз ацетилсалициловой кислоты в качестве антиагрегантной терапии необходимо соблюдать осторожность у пожилых пациентов в связи с риском развития желудочно-кишечного кровотечения.
При одновременном приеме ацетилсалициловой кислоты с алкоголем повышен риск повреждения слизистой оболочки желудочно-кишечного тракта и удлинения времени кровотечения.
При длительном применении препарата следует периодически делать общий анализ крови и анализ кала на скрытую кровь.
Effect on the ability to drive mechanisms and
В период лечения препаратами ацетилсалициловой кислоты необходимо соблюдать осторожность при управлении транспортными средствами и занятиях потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций.
Storage conditions
At temperatures above 25 ° C. Keep out of the reach of children.
Dosing and Administration
Препарат принимают внутрь, запивая водой. Таблетку можно проглотить целиком, разжевать или предварительно растереть.
The preparation is intended for long term use. Длительность лечения препаратом Тромбитал Форте определяется врачом. В 1 таблетке Тромбитал Форте содержится 150 мг ацетилсалициловой кислоты. При необходимости, по решению врача, возможно снижение суточной дозы ацетилсалициловой кислоты до 75 мг (см. раздел «Особые указания»).
Первичная профилактика сердечно-сосудистых заболеваний, таких как тромбоз и острая сердечная недостаточность при наличии факторов риска (например, сахарный диабет, гиперлипидемия, артериальная гипертензия, ожирение, курение, пожилой возраст) – по 1 таблетке 1 раз в сутки.
Профилактика сердечно-сосудистых заболеваний: повторного инфаркта миокарда, тромбоза кровеносных сосудов – по 1 таблетке 1 раз в сутки.
Профилактика тромбоэмболии после хирургических вмешательств на сосудах (например, аорто-коронарное шунтирование, чрескожная транслюминальная коронарная ангиопластика и др. ) – по 1 таблетке 1 раз в сутки.
Нестабильная стенокардия (включая подозрение на развитие острого инфаркта миокарда) – по 1 таблетке 1 раз в сутки.
При нестабильной стенокардии при подозрении на развитие острого инфаркта миокарда первую таблетку необходимо разжевать для более быстрого всасывания.
Use according to the drug only indications that the application and in those doses which are specified in the instruction.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

Trombital

There are no reviews yet.

Add your review