Trimedat Fort Tab n / a film about prolong.vysv. 300mg 20 pieces

$13.32

Trimedat Fort Tab n / a film about prolong.vysv. 300mg 20 pieces

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SKU: 01486954014 Categories: , , Tag:

Description

Composition
Active substance:
1 tablet comprises: trimebutine maleate – 300mg ;.
Excipients:
Microcrystalline cellulose, povidone (K 25), hypromellose, magnesium stearate; shell composition: Opadry II 85F18422: partially hydrolyzed polyvinyl alcohol, macrogol 3350, titanium dioxide E 171, talc.
Description:
Round biconvex tablets, film-coated white embossed symbol in the form of two droplet elements on one side. The cross-sectional core of a white or nearly white.
Product form:
Tablets with a sustained release film-coated, 300 mg.
10 tablets in blisters or contour cell package with perforations of a film with aluminum foil and polyvinylchloride. 1, 2 or 6, contour packs together with instructions for use placed in a pile of cardboard.
Contraindications
Hypersensitivity to the components included in the preparation.
Pregnancy.
Children up to age 12 years (for a given dosage form).
Precautions for the use of
The drug Trimedat® forte should be used with caution during breast-feeding, as there are no data on its ability to penetrate into breast milk.
Dosage
300 mg
Indications
Symptomatic treatment of pain, cramps and discomfort in the abdomen, feeling of bloating (flatulence), motor disorders of the intestine with a change in frequency of stool (diarrhea or constipation), indigestion, heartburn, belching, nausea, vomiting associated with functional disorders of the gastrointestinal tract and biliary tract (non-erosive gastroesophageal reflux disease form; cholelithiasis, biliary tract dysfunction, irritable bowel syndrome, sphincter of Oddi dysfunction, postcholecystectomical syndrome).
Postoperative paralytic ileus.
Interaction with other drugs
Drug interaction Trimedat® forte preparation is not described.
Overdose
Cases of drug overdose Trimedat® forte hitherto been reported.
Treatment: removal of preparation, gastric lavage, the appointment of activated charcoal, symptomatic therapy. There are no specific antidotes.
pharmachologic effect
Pharmacological group:
Antispasmodic.
Pharmacodynamics:
Trimebutine, acting enkefalinergicheskuyu bowel system, it is a regulator of motility. With affinity receptor stimulation and suppression, has a stimulating effect in states hypokinetic intestinal smooth muscle spasmolytic and – at hyperkinetic. The drug acts throughout the gastrointestinal tract, reduces the pressure of the sphincter of the esophagus, promotes gastric emptying and increase intestinal motility, as well as contributes to the response of smooth muscles of the colon to food stimuli. Trimebutin restores the normal physiological activity of the muscles of the intestine in various diseases of the gastrointestinal tract associated with impaired motor skills.
Pharmacokinetics:
After oral administration, trimebutine is rapidly absorbed from the gastrointestinal tract. The degree of binding to plasma proteins is approximately 5%. Trimebutine slightly penetrates the placental barrier. Trimebutine biotransformed in the liver and excreted in the urine primarily as metabolites.
A study in healthy volunteers with single dose of the drug Trimedat® forte values ​​of pharmacokinetic parameters of the active metabolite of trimebutine-2-methylamino-2-phenylbutyl-3,4,5-trimetoksibenzoata (desmetiltrimebutina) were: maximum concentration (Cmax) – 441,45 ± 252 , 99 ng / ml; the time to achieve (Tmax) – 2,20 ± 1,01 hours; the average retention time in the organism (MRT) – 17,12 ± 3,14 hours; luvyvedeniya-period (T1 / 2) – 12,52 ± 4,54 hours; volume of distribution (Vd) – 1279,72 ± 1108,53 l, total clearance (CLt) – 66,51 ± 34,34 l / h.
Pregnancy and breast-feeding
In experimental studies revealed no data on the teratogenicity and embryo toxicity of the drug. However, due to the lack of clinical data, use of the drug Trimedat® forte during pregnancy is contraindicated.
Do not appoint Trimedat® fort during lactation, due to the lack of reliable clinical data supporting the safety of the drug during this period. If necessary, use during lactation should stop breastfeeding.
Conditions of supply of pharmacies
Without a prescription.
side effects
From the digestive system: dry mouth, unpleasant taste, diarrhea, dyspepsia, nausea, constipation.
From the nervous system: drowsiness, fatigue, dizziness, headache, restlessness.
Allergic reactions: skin rash.
Other: menstrual disorders, painful breast enlargement, urinary retention.
special instructions
To prevent recurrence of irritable bowel syndrome after the course of treatment during remission it is recommended to continue receiving a dose of 300 mg per day for 12 weeks.
Effects on ability to drive vehicles and management mechanisms:
The drug does not have a sedative effect, it does not affect the speed of psychomotor reaction and can be used in people of different professions, including those requiring special attention and coordination of movements. However, considering the possible side effects that may affect these abilities (dizziness, etc.), be careful when managing road and busy with other potentially hazardous activities.
Storage conditions
The original package at a temperature not higher than 25 C.
Keep out of the reach of children.
Dosing and Administration
Inside. Adults and children over 12 years: 1 tablet 2 times a day (with a break of 12 hours). treatment of abdominal pain associated with functional disorders of the digestive tract and biliary tract – 28 days.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

Valenta Pharm

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