Trihopol Valium vaginas. 500mg 10 pieces

Description

Composition Active ingredient: 1 tablet contains: Metronidazole 500 mg. Excipients: 1 tablet contains microcrystalline cellulose, povidone, crospovidone, colloidal silicon dioxide, stearic acid. Description: Oblong, biconvex tablets of white color with a yellowish tint. Form: Tablets 500 mg vaginal. 5 or 10 tablets in a blister made of PVC / Al foil. 1 or 2 blisters together with instructions for medical application is placed in a cardboard box. Hypersensitivity to metronidazole or to other nitroimidazole derivative; blood diseases, leukopenia (including in history); incoordination, organic lesions of the central nervous system (including epilepsy); hepatic failure (in the case of large doses of the destination), pregnancy (I term), lactation. Carefully: pregnancy (II – III trimesters), leukopenia history. Dosage 500 mg Indications Local treatment of Trichomonas and nonspecific vaginitis, bacterial vaginosis. Interaction with other medicinal products is compatible with sulfonamides and antibiotics. In the treatment with metronidazole should avoid alcohol intake (similar to disulfiram causes alcohol intolerance). Metronidazole should not be combined with disulfiram, since the interaction of these drugs may oppression of consciousness, the development of mental disorders. With the simultaneous use of warfarin and other indirect anticoagulants metronidazole enhances their action which leads to an increase in prothrombin time. Do not combine with non-depolarizing muscle relaxants (vecuronium bromide). Under the influence of barbiturates may reduce the effect of metronidazole, as is accelerating its inactivation in the liver. Cimetidine inhibits metabolism of metronidazole, which may lead to an increase in its concentration in the blood serum and an increased risk of adverse reactions. Together with the admission lithium drugs may increase the plasma concentration of the latter. The drugs Group: Antimicrobial and protivoprotozoynoe means. Pharmacodynamics: Metronidazole relates to 5-nitroimidazole and a DNA-tropic type of drug with a bactericidal action. The mechanism of action of metronidazole is in the biochemical reduction of 5-nitro group of metronidazole intracellular transport proteins of anaerobic microorganisms and protozoa. The recovered 5-nitro group of metronidazole is reacted with DNA of microbial cells, inhibiting synthesis of nucleic acids, which leads to the death of microorganisms. Metronidazole is an effective antibacterial and antiprotozoal agent wide spectrum of action. The drug shows high activity against Trichomonas vaginalis, Gardnerella vaginalis, Giardia intestinalis, Entamoeba histolytica, Lamblia spp., As well as obligate anaerobe Bacteroides spp. (Including, Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus), Fusobacterium spp., Veillonella spp., Prevotella (Prevotella bivia, Prevotella buccae, Prevotella disiens) and some Gram-positive organisms (Eubacterium spp., Clostridium spp., Peptococcus spp., Peptostreptococcus spp., Mobiluncus spp. ). Pharmacokinetics after administration of intravaginal metronidazole in the form of tablets is subjected to systemic absorption (about 56%). Penetrates into breast milk and most tissues, passes through the blood-brain barrier and placenta. Communication with plasma proteins – less than 20%. It is metabolized in the liver by hydroxylation and oxidation glyukuronirovaniya. Activity of the main metabolite (2-oximetronidazole) is 30% of the activity of the parent compound. TCmax is 6 – 12 hours Provided by 40-70% (about 20% in unmodified form) through the kidneys.. Pregnancy and lactation Metronidazole crosses the placenta and should not be prescribed the drug in the I trimester of pregnancy, in the future should only be used if the potential benefits of the drug in the mother than the potential risk to the fetus. Metronidazole passes into breast milk. Breast-feeding in the period of the drug should be canceled. Resuming breastfeeding should be no earlier than 48 hours after drug application. from the pharmacy dispensing conditions on medical prescription. Side effects when applied topically, you may experience the following side Effect: • itching, burning, pain and irritation in the vagina; thick, white, mucus from the vagina odorless or low-odor, frequent urination; after discontinuation of the drug – the development of vaginal candidiasis; • burning sensation or irritation of the penis in the sexual partner; • the part of the gastrointestinal tract: nausea, change in taste, metallic taste in the mouth, dry mouth, reduced appetite, cramping abdominal pain, nausea, vomiting, constipation or diarrhea; • allergic reaction: hives, itching, skin rash; • headache, dizziness; • leukopenia or leukocytosis; In rare cases, incontinence can be observed staining in the red-brown color, due to the presence of water-soluble pigment formed from the metabolism of metronidazole. Special instructions: In the case of trichomoniasis to the simultaneous treatment of sexual partner drug, no matter if they have any symptoms of the disease. In the period of treatment is recommended to abstain from sexual intercourse. When specifying a history of changes in the peripheral blood, and when using the drug in high doses and / or at its long-term use requires monitoring of total blood analysis. Metronidazole may immobilize Treponema, which leads to false positive TPI test (Nelson). Should pay attention to patients, especially drivers of vehicles and persons that control other machines, to the possibility of dizziness associated with taking the drug. Storage conditions in a dry, dark place at a temperature not higher than 25 ° C. Keep out of the reach of children. Dosing and dose Intravaginal adults. Trichomonas vaginitis: 1 vaginal tablet daily for 7-10 days in combination with taking the drug metronidazole tablets. Nonspecific vaginitis, bacterial vaginosis: 1 vaginal tablet daily for 7 days, if necessary in conjunction with the reception of the drug metronidazole tablets. metronidazole treatment should not last more than 10 days and recur more often than 2 – 3 times a year. Pre-relieving pill contour of package with scissors (film cut along the contour of the tablet), a pill moisten cooled boiled water and introduce it deep into the vagina. Info appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist