Travokort cream 15 g

$17.20

Travokort cream 15 g

Quantity:

SKU: 01036689899 Categories: , , Tags: ,

Description

Composition
Active substance:
100 g of cream contains: diflucortolone valerate – 0.1 g, isoconazole nitrate -1.0 g
Excipients:
Polysorbate 60 – 3.5 g of sorbitan stearate – 1.0 g cetostearyl alcohol (60% cetyl alcohol, stearyl alcohol 40%) – 5.0 g Liquid paraffin – 10.0 g White petrolatum – 10.0 g disodium edetate – 0.1 g purified water – 69.3 g
Description:
White or slightly yellowish opaque, homogeneous cream.
Product form:
Cream for topical application 1 mg + 10 mg / g to 15 g, 20 g or 30 g of an aluminum laminated polyethylene tube, sealed with a membrane with a polyethylene screw cap. Tube with instructions for use placed into cardboard pack.
Contraindications
Hypersensitivity to the active components of the preparation and / or any excipients. Tuberculosis, syphilis, virus diseases (varicella zoster), rosacea, perioral dermatitis, and post-vaccination skin reactions at the site of drug. Pregnancy – I trimester.
Children under 2 years old.
Precautions – pregnancy II and III trimester, during breastfeeding.
Dosage
1 mg + 10 mg / g
Indications
Superficial fungal infections of the skin, accompanied by severe inflammatory or ekzemopodobnye symptoms, including localized in the skin folds, interdigital spaces, groin and vulva.
Interaction with other drugs
Not found.
Overdose
When applied topically Travokort® drug overdose phenomena are unlikely, however, in case of accidental ingestion, as well as when applied to extensive areas of skin, when used for a long time and / or when using occlusive dressings may develop phenomena characteristic of systemic corticosteroids. No specific antidote. If necessary symptomatic treatment.
pharmachologic effect
Pharmacological group:
Glucocorticosteroid + topical antifungal agent.
Pharmacodynamics:
Isoconazole – synthetic derivative of imidazole. It has a broad antifungal and antibacterial spectrum of action. Acts fungicidal and bactericidal. Active against dermatophytes Trichophyton spp., Microsporum spp., Epidermophyton spp., Molds, yeasts and yeast-like fungi of the genus Candida, and pathogen Corynebacterium minutissimum erythrasma and Gram-positive bacteria (Staphylococcus spp., Streptococcus spp).
Diflucortolone valerate – glucocorticosteroid for outdoor use. It has anti-inflammatory, antiekssudativnoe, antiallergic and antipruritic effect.
Pharmacokinetics:
A study of the pharmacokinetics of the drug has not been Travokort®. When studying the pharmacokinetics and active components isoconazole diflucortolone been shown: isoconazole rapidly penetrates the skin, and the maximum concentration (7 mmol / L) was reached in the stratum of the epidermis and underlying layers through 1 hour after application of the drug, a high concentration isoconazole maintained for at least 7 hours. Isoconazole detected in an amount exceeding the minimum inhibitory concentration in the stratum corneum and hair follicles after one week after two weeks of completion of the period of application. Isoconazole is not metabolized in the skin; systemic exposure due to the penetration of isoconazole through the skin, is low. Isoconazole no effect on percutaneous permeability diflukotolon-21-valerate, which penetrates quickly into the skin and its concentration (about 0.3 mmol / L) was reached in the stratum corneum through 1 hour after application to the skin. Diflucortolone 21-valerate partially hydrolyzed in the skin to diflucortolone having the same efficiency. Systemic absorption is negligible. When injected into the systemic circulation diflucortolone 21-valerate, diflucortolone and hydrolyzed to several metabolites and excreted by the kidneys and partly through the intestines.
Pregnancy and breast-feeding
Pregnancy.
Data on the use of the drug Travokort® in pregnant women is limited. The drug is contraindicated for use in the I trimester of pregnancy. Use of the drug
Travokort® in II – III trimesters of pregnancy is possible if the potential benefit to the mother outweighs the potential risk to the fetus. The drug comprises a glucocorticosteroid, however in need of treatment of II – III trimesters not use the drug on extensive skin surfaces and / or long; not use occlusive dressings.
During breastfeeding.
Use of the drug Travokort® during breastfeeding possible if greater than the potential risk to the child’s potential benefit to the mother. It is not known whether the active components Travokort® drug in breast milk. It is recommended to resolve the issue of termination of breastfeeding, if necessary, application of the drug Travokort® in the chest area, large areas, long-term treatment, or the use of occlusive dressings.
Fertility.
These pre-clinical studies have not identified a risk in relation to fertility.
Conditions of supply of pharmacies
Prescription /.
side effects
In clinical trials, the most frequently observed adverse reactions include irritation and burning in the area of ​​applying the cream on the skin.
We can not exclude adverse reactions in infants whose mothers used the drug Travokort® on extensive areas of the skin, prolonged and / or occlusive dressings used during pregnancy or breast-feeding (for example, reduced adrenocortical function, immunosuppression).
The frequency of adverse reactions is determined in accordance with the evaluation rules frequencies
WHO: very common (> 1/10); often (by> 1/100 to
special instructions
When allergic reactions or irritations at the site of drug treatment is stopped. Avoid contact Travokort® drug in the eyes and open wounds. Because the drug comprises a glucocorticosteroid may develop glaucoma (e.g., when used in high doses for a long time intensive application, when using occlusive dressings applied to the skin or eye). If the disease is complicated by the development of secondary bacterial infection, a drug therapy
Travokort® need to add a specific antibacterial agent. When applying the preparation to the pudendal region and use during treatment barrier contraceptive, the risk of breaking the condom or diaphragm increases, as included in the formulation of liquid paraffin and petrolatum can cause damage contraceptive products of latex, thus reducing their effectiveness. You must use reliable methods of contraception. During treatment to observe good personal hygiene.
Effects on ability to drive and use machines.
Not found.
Storage conditions
Store at a temperature not higher than 25 ° C.
Keep out of the reach of children.
Dosing and Administration
Outwardly. Adults and children over 2 years of preparation Travokort® applied thinly to the affected areas of skin 2 times a day. If it affects the fingers or toes is recommended to lay between them gauze soaked in cream. The duration of treatment should not exceed 2 weeks. If necessary, further treatment may continue therapy with antifungal drugs without content glucocorticosteroid.
The use in children.
It does not need to specifically adjust the dose when using the drug Travokort® in children aged 2 years and older and adolescents.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

LEO PHARMA

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