Tizin classic spray Nazal. scrapper. 0.05% 10ml vial 1 piece

Description

Composition
Active substance:
In 1 ml of solution contains: Active substance: Xylometazoline hydrochloride 0.5 mg (0.05%) or 1.0 mg (0.1%); amount of active ingredient in one dose to 0.05% – 0.035 mg Xylometazoline hydrochloride; to 0.1% – 0.14 mg Xylometazoline gidrohlo-chloride.
Excipients:
Benzalkonium chloride, 70% sorbitol, sodium chloride, sodium dihydrogen phosphate dihydrate, disodium hydrogen phosphate dihydrate, disodium edetate, purified water.
Description:
Transparent colorless solution odorless or with a faint characteristic odor.
Product form:
Cprey nasal dosage 0.05% and 0.1%.
10 ml of the drug in vial hydrolytic brown glass (Class III) with a metering device and a polyethylene screw cap.
One vial with instructions for use in a pile of cardboard.
The number of doses per vial: 0.05% for at least 140 doses of 0.1% for not less than 70 doses.
Contraindications
Hypersensitivity to any of the components of the preparation, simultaneous reception of monoamine oxidase (MAO) inhibitors or other drugs that may cause increased blood pressure; hypertension, tachycardia expressed arteriosclerosis, glaucoma, atrophic rhinitis, surgical interventions in the meninges (history), children (under 6 years – to 0.1% dosage, aged 2 – Dosing 0.05%).
Be wary – ischemic heart disease (angina), prostatic hyperplasia, hyperthyroidism, diabetes mellitus, pheochromocytoma in patients with hypersensitivity to adrenoceptor agonists, accompanied by symptoms of insomnia, dizziness.
Dosage
0.5 mg / ml
Indications
To reduce swelling of the mucosa of the nasopharynx and exudates during acute allergic rhinitis, acute respiratory disease with symptoms of rhinitis, sinusitis, hay fever, otitis media.
Preparing the patient for diagnostic procedures in the nasal passages.
Interaction with other drugs
The simultaneous use of MAO-inhibitors or tranylcypromine tricyclic antidepressants can lead to increased blood pressure due to cardiovascular effects of these substances.
Overdose
symptoms of intoxication
Overdose or accidental intake of the drug inside can cause the following symptoms: dilated pupils, nausea, vomiting, cyanosis, fever, spasms, tachycardia, cardiac arrhythmia, collapse, cardiac arrest, hypertension, pulmonary edema, respiratory failure, mental disorders.
In addition, the following symptoms may occur: the function of suppressing the central nervous system, accompanied by drowsiness, decrease in body temperature, bradycardia, hypotension, shock-like, apnea and coma.
treatment of intoxication
The use of activated charcoal, gastric lavage, administration of artificial respiration with oxygen. To reduce arterial pressure is applied 5 mg phentolamine at physiological solution by slow intravenous injection, or 100 mg orally.
Vasopressor agents are contraindicated. If necessary apply antipyretic and anticonvulsants.
pharmachologic effect
Pharmacological group:
Decongestant agent – vasoconstrictor (alpha-agonists).
Pharmacodynamics:
Xylometazoline (imidazole derivative) – sympathomimetic drug with alpha-adrenergic activity. It has vasoconstrictor effect and reduces puffiness mucosa.
The action usually begins within 5-10 minutes. Preparation facilitates nasal breathing by reducing edema and hyperemia of the mucosa, and also improves the discharge of secretions.
Pharmacokinetics:
When applied topically, practically not absorbed, the plasma concentrations are so small that they can not identify with modern analytical methods.
Pregnancy and breast-feeding
Pregnancy
Carefully controlled studies and the corresponding necessary requirements have not been conducted in pregnant women. The drug should not be used during pregnancy except in cases where the potential benefit of treatment of the mother than the potential risk to the developing fetus.
Lactation
It is not known whether xylometazoline or its metabolites are excreted in breast milk, so the drug should not be used during breastfeeding.
Conditions of supply of pharmacies
Available without prescription.
side effects
Tizin® Classic can cause transient slight irritation of the nose (burning), paresthesia, sneezing and hypersecretion in susceptible people.
In some cases, the drug can be observed increased swelling of the nasal mucosa (reactive hyperemia).
Long term or repeated use Xylometazoline or use it in high doses may cause a burning sensation in the nose or mucosal dryness, as well as stagnation reactive with the development of medical rhinitis. This effect can be observed even after 5-7 days after treatment and during long-term use may cause irreversible damage to the mucous membrane to form crusts (sicca).
In very rare cases may experience headaches, insomnia or fatigue, depression (with prolonged use at high doses).
In rare cases, local intranasal administration may be accompanied by systemic sympathomimetic effects, such as palpitations, tachycardia, arrhythmias, increased blood pressure, impaired vision.
special instructions
Long-term use and overdose sympathomimetics providing dekongestivnoe action may lead to reactive hyperemia nasal mucosa.
The phenomenon of recoil can cause obstruction of the airways, which leads to the fact that the patient begins to use the drug again, or even permanently. This can lead to chronic swelling (rhinitis medicamentosa), and eventually even to atrophy of nasal mucosa (ozena).
In the case of chronic rhinitis drug Tizin® Classic 0.05% and 0.1% may be used only under medical supervision, given the risk of atrophy of nasal mucosa.
Classic Tizin® not be used in the presence of hypersensitivity to benzalkonium chloride, which is a part of the preparation as a preservative.
Do not exceed the recommended dose, especially in children and the elderly.
Prolonged treatment or use of the drug Classic Tizin® higher doses can not exclude the possibility of systemic effects on the cardiovascular system, which may impair the ability to drive and use of appliances.
Storage conditions
Store at a temperature not higher than 25 ° C.
Keep out of the reach of children.
Dosing and Administration
Children aged 2-6 years
Unless otherwise designated, one dose of the drug Tizin® Classic in a 0.05% nasal spray metered into each nasal passage 1-2 times a day.
Adults and children of school age (older than 6 years old) 3 times per day administered in a single dose preparation Tizin® Classic as a 0.1% nasal spray metered into each nostril. The dose depends on the individual sensitivity of the patient and the clinical effect.
Xylometazoline in the form of a nasal spray metered should not be used more than 5-7 days, if the doctor did not recommend a different treatment duration.
After completion of therapy, the drug can be administered again in just a few days.
About the length of the children always consult with a physician.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist