Tiolepta Tab n / a film about 600mg 30 pieces kanonfarma

Description

Composition
Active substance:
1 tablet contains: thioctic acid (alpha-lipoic acid) 600 mg ;.
Excipients:
Calcium stearate 31 mg Potato starch 27.4 mg colloidal silica 27.6 mg, 49.6 mg croscarmellose sodium, lactose monohydrate 232 mg Povidone K-30 65.2 mg microcrystalline cellulose 167.2 mg;
composition of the film coating: Opadry yellow 40mg, including: hypromellose (hydroxypropylmethylcellulose) 13.6 mg, giproloza (hydroxypropyl cellulose) 14 mg Titanium dioxide 10.74 mg, colorant ferric oxide 1.652 mg yellow, sunset yellow colorant 0.008 mg.
Description:
Tablets, film-coated brownish-yellow, oval. At the turn of the tablets of light yellow color.
Product form:
Tablets, film-coated, 600 mg.
At 10 or 15 tablets in blisters of PVC film and aluminum foil printed patent.
3, the contour of cellular packages 6 to 10 tablets, or 2, 4 blisters with 15 tablets with instructions for use placed in a pile of cardboard.
Contraindications
Hypersensitivity to thioctic acid or other ingredients;
pregnancy, breast-feeding (not enough experience with the drug);
Children up to age 18 years (effectiveness and safety have not been established);
lactose intolerance, lactase deficiency, glucose-galactose malabsorption.
Dosage
600 mg
Indications
Diabetic neuropathy;
alcoholic polyneuropathy.
Interaction with other drugs
With simultaneous application thioctic acid and cisplatin marked decrease in the efficiency of cisplatin.
Thioctic acid binds the metals, so it should not be used simultaneously with preparations containing metals (e.g., iron preparations, magnesium, calcium), as well as dairy products (due to the content of calcium); the interval between doses of such preparations and thioctic acid should be at least 2 hours.
With simultaneous application thioctic acid and insulin or oral hypoglycemic agents their effect can be enhanced.
It enhances the anti-inflammatory action of glucocorticoids.
Ethanol and its metabolites weaken the effect of thioctic acid.
If you are already taking other medicines or are going to take them, before taking Tiolepta® medication should consult a physician.
Overdose
Symptoms: headache, nausea, vomiting.
Treatment: symptomatic (including gastric lavage, activated charcoal), if necessary – anticonvulsant therapy, measures to support vital functions.
pharmachologic effect
Pharmacological group:
Metabolic means.
Pharmacodynamics:
Thioctic acid (alpha-lipoic acid) – endogenous antioxidant (binds free radicals) in the body formed by the oxidative decarboxylation of alpha-keto acids. As coenzyme mitochondrial multienzyme complexes involved in the oxidative decarboxylation of pyruvic acid and alpha-keto acids. Improves trophic neurons. Thereby reducing blood glucose and increased glycogen content in the liver, and reduce insulin resistance. Participates in the regulation of lipid and carbohydrate metabolism, stimulates cholesterol metabolism, improves liver function.
In diabetes thioctic acid reduces the formation of advanced glycation end products, improves endoneurial blood flow, increases glutathione levels to physiological values ​​that results in the improvement of the functional status of peripheral nerve fibers in diabetic polyneuropathy.
Pharmacokinetics:
When ingestion rapidly and completely absorbed in the gastrointestinal tract, the reception at the same time reduces the absorption of food. The time to reach maximum concentration of 40-60 minutes. Bioavailability – 30%.
It has the effect of “first pass” through the liver. It is metabolized in the liver by the oxidation of side chain conjugation.
The volume of distribution – about 450 ml / kg. Total plasma clearance – 10-15 ml / min. Thioctic acid and its metabolites are excreted by the kidneys (80-90%). The half – 20-50 min.
Pregnancy and breast-feeding
Admission thioctic acid is contraindicated during pregnancy and breastfeeding due to lack of sufficient experience of application.
Conditions of supply of pharmacies
On prescription.
side effects
The incidence of adverse reactions is given in accordance with the WHO classifications: very frequent -> 1/10 assignments (> 10%) frequently – by> 1/100 to 1%, and
special instructions
Patients taking the drug Tiolepta®, should refrain from drinking alcohol, because this reduces the therapeutic effect and is a risk factor for the progression of neuropathy.
In patients with diabetes requires constant monitoring of blood glucose concentration, especially at the initial stage of therapy. In some cases it is necessary to reduce the dose of insulin or oral hypoglycemic agents, in order to avoid hypoglycemia.
Effect on the ability to drive mechanisms and
The drug has no effect on ability to drive and operate machinery that require attention.
Storage conditions
In a dry, dark place at a temperature not higher than 25 C.
Keep out of the reach of children.
Dosing and Administration
Inside fasting for approximately 30 minutes before the first meal, liquid squeezed a sufficient amount of water to 600 mg (1 tablet) 1 time per day. The maximum daily dose – 600 mg.
The duration of treatment determined by the doctor.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist