Tinidazole-acre Table n / 500mg film about 4 pc

Description

Composition
Active substance:
One tablet contains: tinidazole – 500 mg
shell composition: hypromellose (hydroxypropylmethyl cellulose), Macrogol (polyethylene glycol 6000), glycerol (glycerine), titanium dioxide, talc.
Excipients:
One tablet contains: pregelatinized starch, sorbitol, potato starch, talc, stearic acid.
Description:
Tablets, film-coated, white or white with Valium or greyish shade, round, biconvex. At the turn of tablets or white with a yellowish tint zheltovatozelenovatym.
Product form:
Tablets, film-coated, 500 mg. 4 tablets in blisters. 1 blisters together with instructions for use in a stack of cardboard.
Contraindications
Increased sensitivity to the drug or other derivative of 5-nitroimidazole, organic central nervous system diseases, hemopoietic disorders, I trimester of pregnancy, lactation, infancy (up to 12 years).
Dosage
500 mg
Indications
• trichomoniasis (colpitis, endometritis, ovarian tubovarialnye and abscesses); • giardiasis; • amebiasis (including hepatic and intestinal forms); • infections caused by anaerobic bacteria (for pneumonia, empyema, lung abscess, skin and soft tissue infections, acute ulcerative gingivitis); • mixed aerobic-anaerobic infection (in conjunction with antibiotics); • eradication of Helicobacter pylori (in combination with bismuth preparations and antibiotics). The drug is used for the prevention of postoperative infectious complications caused by anaerobes.
Interaction with other drugs
Proximity effect anticoagulants (to reduce the risk of bleeding dose reduced by 50%) and the effect of ethanol (disulfiramopodobnyh effect).
Compatible with sulfonamides and antibiotics (aminoglycosides, erythromycin, rifampin, cephalosporins). Not recommended for use with ethionamide. Phenobarbital accelerates metabolism.
Cautions simultaneous treatment of both partners should be the treatment of trichomoniasis.
During treatment should refrain from the use of ethanol (possibility of disulfiramopodobnyh reactions).
Causing dark urine staining. In the treatment of more than 6 days is necessary to monitor patterns of peripheral blood.
In the period of treatment should refrain from activities potentially hazardous activities that require high concentration and psychomotor speed reactions.
Overdose
Treatment is symptomatic. There is no specific antidote. Tinidazole displayed during dialysis.
pharmachologic effect
Pharmacological group:
Antimicrobial and protivoprotozoynoe means.
Pharmacodynamics:
Antiprotozoal preparation with antimicrobial activity. It is active against Trichomonas vaginalis, Entamoeba histolytica, Lamblia. It has bactericidal activity against anaerobic microorganisms following: Bacteroides spp, (including B. fragilis, B. melaninogenicus), Clostridium spp,..
Eubacterium spp., Fusobacterium spp., Peptococcus spp., Peptostreptococcus spp., Veillonella spp. The mechanism of action is due to inhibition of DNA synthesis and structure damage pathogens.
Pharmacokinetics:
Absorption – high, bioavailability – about 100%. Relationship to plasma proteins – 12%. Maximum plasma concentration achieved after oral administration of 2 g of – 40-51 mcg / mL, after 24 hours – 11-19 mcg / mL, after 72 hours – 1 ug / ml. The maximum concentration is achieved after 2 hours Volume of Distribution -. 50 l. Penetrates the blood-brain barrier, placenta. Excreted in breast milk over 72 hours after administration.
It is metabolized in the liver to produce pharmacologically active hydroxylated derivatives which inhibit the growth of anaerobic microorganisms, and can enhance the effect of tinidazole. The half -. 12-14 hours Return to bile – 50% kidney – 25% (unchanged) and 12% (as metabolites) due to reabsorption in the renal tubules.
Pregnancy and breast-feeding
The drug is contraindicated for use in the I trimester of pregnancy. Application in II and III trimesters of pregnancy is possible only in those cases where the intended benefits to the mother outweighs the potential risk to the fetus.
If necessary, use during lactation should decide the issue of termination of breastfeeding. Note that tinidazole is determined in breast milk over 72 hours after administration.
Conditions of supply of pharmacies
On prescription.
side effects
On the part of the gastrointestinal tract: possible anorexia, dryness and bad taste in the mouth, nausea, vomiting, diarrhea.
Central nervous system: headache, dizziness, ataxia, peripheral neuropathy; rarely – seizures.
Allergic reactions: urticaria, pruritus, rash, angioedema.
Other: rarely – transient leukopenia, fatigue.
Storage conditions
In a dry, dark place at a temperature not higher than 25 ° C.
Keep out of the reach of children.
Dosing and Administration
The tablets are taken orally during or after meal.
If trichomoniasis and giardiasis drug administered singly adult to 2 g / day; children at the rate of 50-75 mg / kg body weight per day. If necessary, the drug can be repeated at the same dose. When intestinal amebiasis daily dose for adult is 2 g, of drug taking 2-3 days.
Babies tinidazole administered at the rate of 50-60 mg / kg / day; course of treatment – 3 days.
When hepatic amebiasis adult drug administered in an initial dose of 1.5-2 g / day. The course of treatment – 3 days, if necessary, treatment duration may be increased up to 6 days. Heading dose depending on the severity of the infection is 4.5-12 g tinidazole Babies are administered in dosages calculated to 50-60 mg / kg / day; duration of treatment – 5 days.
In the treatment of infections caused by anaerobes grown on the first day of treatment administered 2 g / day in 1 reception, followed by 1 g / day. Treatment continued for 5-6 days.
For the prevention of adult postoperative complications administered 2 g once per 12 hours prior to surgery.
The safety and efficacy of the drug for the treatment and prevention of anaerobic infections in children under 12 years of age have not been established.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist