Timolol Akos drops Ch. 0.5% 5ml vial-cap.

$0.70

Timolol Akos drops Ch. 0.5% 5ml vial-cap.

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Description

Composition
Active substance:
1 ml contains: Timolol maleate (equivalent to Timolol) – 2.5 mg or 5.0 mg.
Excipients:
Alkyldimethylbenzylammonium chloride (benzalkonium chloride) – 0.1 mg sodium dihydrogen phosphate (monobasic sodium phosphate 2 aq) – 7.26 mg sodium [phosphate] dodecahydrate (sodium phosphate dibasic 12-water, disodium phosphate dodecahydrate) – 28.6 mg water for injection – up to 1 ml.
Product form:
Eye drops of 0.25% and 0.5%. 5 or 10 ml vials polyethylene dropper. Each vial-dropper with instructions for use placed in a pile of cardboard.
Contraindications
Hypersensitivity, degenerative processes in the cornea, bronchial asthma (including history), severe chronic obstructive pulmonary disease, sinus bradycardia, atrioventricular block II-III art., Asthma, chronic heart failure, cardiogenic shock, children up to 18 years lactation.
Dosage
0.5%
Indications
Ocular hypertension, open-angle glaucoma, secondary glaucoma (uveal, afakicheskaya, posttraumatic);
As an auxiliary drug: angle-closure glaucoma (in combination with miotikami), congenital glaucoma (with the ineffectiveness of other therapeutic measures.), A sharp increase in intraocular pressure.
Interaction with other drugs
Epinephrine and pilocarpine enhance the hypotensive effect of timolol. Simultaneous administration of eye drops containing epinephrine can cause dilatation of the pupil (mydriasis).
Concomitant administration of substances – enzyme inhibitors SYP2D6 system (amiodarone, quinidine, haloperidol, paroxetine, fluoxetine, citalopram, sertraline, terbinafine, ketoconazole, ritonavir, cimetidine) may provoke symptoms timolol overdose, including bradycardic (until the heart rate of less than 40 ppm), in some cases – and profound lethargy.
It enhances the action of general anesthetics and muscle relaxants (for several days prior to general anesthesia with ether or chloroform, or using peripheral muscle relaxants must stop taking the drug). On the background of treatment should be avoided intravenous verapamil, diltiazem (possibly inhibition of atrioventricular conduction, bradycardia and decreased blood pressure).
Precautions administered simultaneously with antihypertensive drugs, other beta-blockers, insulin or oral hypoglycemic drugs, glucocorticosteroid, psychoactive drugs, and drugs whose action is associated with increased release epinephrine.
Overdose
Symptoms may develop obscherezorbtivnyh effects typical of beta-blockers (dizziness, headache, arrhythmia, bradycardia, bronchospasm, nausea, vomiting).
pharmachologic effect
Pharmacological group:
Antiglaucoma agents – beta-blocker.
Pharmacological properties:
Non-selective beta-adrenoceptor blockers without sympathomimetic activity. When applied topically, reduces intraocular pressure by decreasing the formation of aqueous humor, and a small increase in its outflow. Reducing the intraocular pressure does not affect the accommodation and pupil size, so there is no deterioration in visual acuity and quality is not reduced night vision. Action manifests 20 min after instillation, the maximum effect – in 1-2 hours; duration – 24 hours.
Pharmacokinetics:
After instillation of eye drops in the moisture anterior chamber time to maximum concentration -. 2.1 hours active agent enters the systemic circulation by absorption through the conjunctiva, mucous membrane of the nasal and lacrimal tract. The drug is metabolized by CYP2D6 enzyme system. Excretion of metabolites – the kidneys. In newborns, the concentration of active substance is significantly greater than the maximum concentration in the plasma of adults.
Pregnancy and breast-feeding
Use of the drug during pregnancy is possible only when the intended benefits to the mother outweighs the potential risk to the fetus. If the drug is used immediately before birth, the newborn should be closely monitored for several days after birth.
Conditions of supply of pharmacies
On prescription.
side effects
Local reactions: irritation of the conjunctiva – conjunctival hyperemia, lacrimation or decrease tearing, photophobia, corneal epithelium edema, burning and itching in the eyes, redness of the eyelid skin, a short break in visual acuity; blepharitis, conjunctivitis, keratitis, prolonged use may develop superficial punctate keratopathy (reduced corneal transparency) and reduced corneal sensitivity, possible ptosis, rarely – diplopia.
Systemic reactions: paresthesia, rhinitis, nasal congestion, nasal bleeding, reduction in blood pressure, collapse, bradycardia, bradyarrhythmia, atrioventricular block, decreased myocardial contractility, worsening manifestations of chronic heart failure; headache, dizziness, drowsiness, hallucinations, depression, myasthenia gravis, decreased potency; shortness of breath, bronchoconstriction, pulmonary insufficiency; nausea, vomiting, diarrhea, chest pain, ringing in the ears.
Psychomotor slowing of the reaction. Allergic reactions (including urticaria).
special instructions
Monitoring the effectiveness of recommended about 3-4 weeks after initiation of therapy (not earlier than 1-2 weeks). With prolonged use of timolol possible weakening effect. In applying the necessary control slezovydeleniya function integrity of the cornea and to evaluate the magnitude of the fields of view of at least 1 per 6 months. At least 1 time per month to measure intraocular pressure. Preservative contained in the product may be delayed for soft contact lenses (causes discoloration).
May be irritating to the eye when wearing contact lenses, however, any contact lenses should be removed before instillation and wear no earlier than 15 minutes after. When transferring patients to treatment with timolol may need refractive error correction after effects previously applied miotikov.
In the case of the upcoming surgery with general anesthesia is necessary to cancel the drug for 48 h before the operation, since timolol enhances the action of general anesthetics and muscle relaxants.
During treatment, care must be taken when driving and other lesson. Potentially hazardous activities that require high concentration, psychomotor speed of reaction and a good vision (in 0.5 hours after instillation in the eye).
You can mask the beta-blockers symptoms of hypoglycaemia in patients treated with insulin or oral hypoglycemic agents, symptoms of hyperthyroidism (including tachycardia).
Storage conditions
In the dark place at a temperature not higher than 25 ° C. Keep out of the reach of children.
Dosing and Administration
Adults instilled into the conjunctival sac of one drop of 0.25% solution, 2 times a day, with insufficient efficiency – 1 drop of 0.5% solution, 2 times per day.
When normalization intraocular pressure maintenance dose – 1 drop 0.25% 1 time per day. Severity difference between steps 2 concentration is 10-15%.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

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