Tiberal tab n / 500mg film about 10 pc

Description

Composition
Active substance:
One tablet contains: 500 mg of ornidazole
Product form:
The pack of 10 tablets
Contraindications
Hypersensitivity to the drug or other nitroimidazole derivatives.
Carefully:
Care should be taken in patients with CNS diseases such as epilepsy, brain lesions, multiple sclerosis. If you exceed the recommended doses there is a risk in patients with liver disease, alcohol abuse, pregnant and lactating mothers and children.
Pregnancy and lactation
Extensive research on different kinds of animals did not reveal any teratogenic or toxic effect of the drug on the fetus. Controlled studies in pregnant women have been conducted. However, for general health reasons appoint Tiberal early in pregnancy or nursing mothers only if absolutely indicated.
Dosage
500
Indications
Trichomoniasis (urogenital infections in men and women caused by Trichomonas vaginalis); amebiasis (all of intestinal infections caused by Entamoeba histolytica, including amoebic dysentery, and all forms of extra-intestinal amebiasis, especially amebic liver abscess); giardiasis.
Interaction with other drugs
Unlike other nitroimidazole derivative, ornidazole did not inhibit aldehyde dehydrogenase and is therefore incompatible with alcohol. However, ornidazole potentiates the action of oral anticoagulants coumarin, which requires their respective dose adjustment. Ornidazole lengthens muscle relaxant action of vecuronium bromide.
Overdose
Symptoms: The symptoms mentioned under “Side effects”, but in a more pronounced form.
Treatment: specific antidote is unknown; in convulsions – diazepam.
pharmachologic effect
Pharmacodynamics:
Tiberal effective against Trichomonas vaginalis, Entamoeba histolytica, Giardia lamblia (Giardia intestinalis), and also some anaerobic bacteria such as Bacteroides and Clostridium spp., Fusobacterium spp., And anaerobic cocci.
Pharmacokinetics:
Suction
After oral ornidazole rapidly absorbed. The average absorption is 90%.
Maximum plasma concentrations are reached within 3 hours.
Distribution
Binding ornidazole protein is about 13%. Active substance tiberal very well into the cerebrospinal fluid, other body fluids and tissues.
Ornidazole concentration in plasma are in the optimal range for the various indications for use of the drug (6-36 mg / l). The coefficient accumulation after multiple administration doses of 500 mg or 1000 mg in healthy volunteers after every 12 hours is equal to 1.5-2.5.
Metabolism
Ornidazole metabolized in the liver to form, mainly, 2-hydroxymethyl- alpha -gidroksimetilmetabolitov. Both metabolites are less active against Trichomonas vaginalis and anaerobic bacteria than the unmodified ornidazole.
breeding
The half-life is about 13 hours. After a single dose 85% of dose was excreted within the first 5 days, mainly as metabolites. About 4% of the dose is eliminated via the kidneys in unchanged form.
Conditions of supply of pharmacies
Available on medical prescription.
side effects
Mild drowsiness, headaches and gastrointestinal disorders (nausea). In some cases – CNS side effects, such as dizziness, tremor, rigidity, loss of coordination, convulsions, fatigue, temporary loss of consciousness, signs of sensory or mixed peripheral neuropathy.
There have been cases taste perversion, changes in liver function tests, skin reactions and hypersensitivity reactions.
Storage conditions
Store at room temperature out of reach of children.
Dosing and Administration
Tiberal always taken after meals.
trichomoniasis:
1 tablet 2 times a day (morning and evening) for 5 days.
To eliminate the possibility of re-infection, the sexual partner, in all cases, should receive the same treatment.
The daily dose for children is 25 mg / kg body weight administered in one portion.
amebiasis:
Possible treatment regimens: a three-day course of treatment of patients with amoebic dysentery and a 5-10 day course of treatment for all forms of amoebiasis.
Duration of treatment a) for adults and children weighing more than 35 kg:
– 3 days: 3 tablets at one time in the evening. When a body weight of over 60 kg – 4 tablets (2 tablets morning and evening).
– 5-10 days: 2 tablets (1 tablet morning and evening)
b) For children weighing less than 35 kg:
– 3 days: 40 mg / kg body weight at one time – 5-10 days: 25 mg / kg body weight one time
giardiasis:
Adults and children weighing more than 35 kg: 3 tablets once in the evening.
Children weighing less than 35 kg: 40 mg / kg once a day.
The duration of treatment is 1-2 days.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist