Theraflu from the flu and colds powder for solution 22.1g sachet into 10 pieces lemon

$9.19

Theraflu from the flu and colds powder for solution 22.1g sachet into 10 pieces lemon

Quantity:

Description

Composition
Active substance:
Paracetamol 325 mg; pheniramine maleate, 20 mg; Phenylephrine Hydrochloride 10 mg; ascorbic acid 50 mg;
Excipients:
Sodium Citrate dihydrate – 120.74 mg, malic acid, – 50.31 mg, colorant sunset yellow – 0.098 mg dye quinoline yellow – 0.094 mg Titanium dioxide – 3.16 mg, flavor Lemon – 208.42 mg calcium tribasic phosphate – 82 mg Citric acid – 1221.79 mg sucrose – 20,000 mg.
Description:
Powder for oral solution (lime), white with yellow patches, particulate, granular, no foreign particles, citrus odor; tolerance of soft lumps.
Product form:
According to 22.1 grams in a multilayer bag. 10 bags in a carton box. Bags can be placed individually or pairwise fastened. Instructions for use is applied to the bag.
Contraindications
Increased sensitivity to the drug; severe cardiovascular disease; arterial hypertension; portal hypertension; diabetes; hyperthyroidism; closure glaucoma; pheochromocytoma; alcoholism; deficit sucrase / isomaltase, fructose intolerance, glucose-galactose malabsorption; simultaneously or within the previous 2 weeks MAO inhibitors; concomitant use of tricyclic antidepressants, beta-blockers, other sympathomimetic agents; pregnancy; breastfeeding; Children up to age 12 years. Precautions: the atherosclerosis of coronary arteries, cardiovascular diseases, acute hepatitis, hemolytic anemia, bronchial asthma, severe liver disease or kidney disease, prostatic hyperplasia, difficulty of urination due to prostatic hypertrophy, blood diseases, deficiency of glucose-6-phosphate dehydrogenase, congenital hyperbilirubinemia (Gilbert syndrome, Dubin-Johnson and Rotor), when exhaustion, dehydration, piloroduodenalnoy obstruction, gastric and stenosing / yl and duodenum, epilepsy, while taking drugs can adversely affect the liver (e.g., inducers of microsomal liver enzymes); in patients with relapsing form uric acid kidney stones.
Indications
Symptomatic treatment of infectious and inflammatory diseases (SARS, including influenza), accompanied by high fever, chills, body aches, headache and muscle pain, runny nose, nasal congestion, sneezing.
Interaction with other drugs
Paracetamol Enhances effects MAO inhibitors, sedatives, ethanol. The risk of hepatotoxicity paracetamol increases while the use of barbiturates, phenytoin, phenobarbital, carbamazepine, rifampicin, isoniazid, zidovudine and other inducers of microsomal liver enzymes. With long-term regular use of paracetamol may increase the anticoagulant effect of warfarin and other coumarin, at the same time it increases the risk of bleeding. A single application of paracetamol has no significant effect. Metoclopramide increases the rate of absorption of paracetamol, and reduces the time to reach its Cmax in blood plasma. Similarly, domperidone may increase the absorption rate of paracetamol. Paracetamol can lead to an increase in T1 / 2 of chloramphenicol. Paracetamol is capable of reducing bioavailability of lamotrigine while it may reduce the effectiveness of lamotrigine due to induction of its metabolism in the liver. Paracetamol absorption may be reduced while the use of colestyramine, but slightly reduced absorption when taken colestyramine one hour later. Regular use of paracetamol together with zidovudine can cause increased risk of neutropenia and liver damage. Probenecid affects the metabolism of paracetamol. Patients simultaneously applying probenecid, the paracetamol dose should be reduced. Hepatotoxicity of paracetamol enhanced by prolonged excessive use of ethanol (alcohol). Paracetamol can affect the test results for the determination of uric acid using a precipitating reagent phosphotungstate. Pheniramine possible enhancement effect on the CNS other substances (e.g., MAO inhibitors, tricyclic antidepressants, alcohol, antiparkinsonian drugs, barbiturates, narcotics and tranquilizers). Pheniramine can inhibit the action of anticoagulants. Phenylephrine Teraflyu® from influenza and colds is contraindicated in patients who receive or received MAO inhibitors during the last 2 weeks. Phenylephrine may potentiate the action of MAO inhibitors and cause hypertensive crisis. Simultaneous application of phenylephrine with other sympathomimetic drugs or tricyclic antidepressants (e.g., amitriptyline) may lead to increased risk of adverse reactions to the cardiovascular system. Phenylephrine may reduce the effectiveness of beta-blockers and other antihypertensive agents (e.g., debrizohina, guanethidine, reserpine, methyldopa). May increase the risk of hypertension and other side effects of the cardiovascular system. Concomitant use of phenylephrine with digoxin and cardiac glycosides may increase the risk of cardiac arrhythmias and myocardial infarction. Concomitant use of phenylephrine with ergot alkaloids (ergotamine and methysergide) may increase the risk of ergotism.
Overdose
Overdose symptoms due mainly paracetamol. Paracetamol Symptoms: mainly manifested after reception 10-15 g paracetamol. In severe cases of acetaminophen overdose has hepatotoxic effects, including It can cause liver necrosis. Also overdose can cause irreversible nephropathy and irreversible liver damage. Intensity of overdose is dose-dependent, so patients should be warned about prohibiting simultaneous reception paratsetamolsoderzhaschih preparations. Risk of poisoning is expressed especially in the elderly, in children, in patients with liver disease, in cases of chronic alcoholism, in patients with malnutrition and in patients taking inducers of microsomal liver enzymes. An overdose of acetaminophen can lead to liver failure, encephalopathy, coma and death. Symptoms of paracetamol overdose in the first 24 hours: pallor of the skin, nausea, vomiting, anorexia, convulsions. The abdominal pain may be the first sign of liver damage and usually does not occur for 24-48 hours, and sometimes can be delayed, after 4-6 days. Liver damage manifests itself to the greatest extent after 72-96 h after dosing. You may also see a violation of glucose metabolism and metabolic acidosis. Even in the absence of liver disease may develop acute renal failure and acute tubular necrosis. Reported cases of cardiac arrhythmias and of pancreatitis. Treatment: administering acetylcysteine ​​/ or orally as an antidote, gastric lavage, administration of methionine can have a positive effect, at least for 48 hours after the overdose. Recommended intake of activated carbon, the monitoring of respiration and circulation. In the case of seizures possible appointment of diazepam. Pheniramine and phenylephrine (overdose symptoms are united because of the risk of mutual potentiation effect parasympatholytics pheniramine and the sympathomimetic effects of phenylephrine in the case of drug overdose)
Symptoms: drowsiness, to which later joined by anxiety (especially in children), visual disturbances, rash, nausea, vomiting, headache, irritability. dizziness, insomnia, circulatory disorders, coma, seizures, behavior changes, increased blood pressure and bradycardia. In overdose cases have been reported pheniramine atropinopodobnye “psychosis”. Treatment: the specific antidote is available. The usual measures necessary assistance, including the appointment of activated charcoal, saline laxatives, measures to support cardiac and respiratory functions. Should not be prescribed psychostimulant agents (methylphenidate) due to the risk of seizures. If hypotension may use vasopressor drugs. In the case of BP increase is possible in / in a alpha-blockers, as Phenylephrine is a selective agonist of? 1-adrenoreceptor therefore hypotensive effect in overdosage should be treated by blocking? 1-adrenergic receptors. With the development of seizures administered diazepam.
pharmachologic effect
Pharmacological group:
N02BE51
Pharmacodynamics:
Combination drug action is due to its constituent components. Has antipyretic, analgesic, vasoconstrictor effect, eliminates the symptoms of “colds”. Narrows vessels and eliminates nasal and nasopharyngeal mucosa edema. Paracetamol has analgesic and antipyretic activity by inhibiting the synthesis of prostaglandins in the CNS. It does not affect the function of platelets and hemostasis. Pheniramine – antiallergic agent, histamine H1-receptor. Eliminates allergic symptoms in moderate has sedative effect and also exhibits antimuscarinic activity. Phenylephrine – alpha1-agonists, causes vasoconstriction, edema and hyperemia eliminates nasal mucosa.
Pharmacokinetics:
Paracetamol Paracetamol is rapidly and almost completely absorbed from the gastrointestinal tract. Cmax plasma achieved in 10-60 minutes after ingestion. Distributed in most tissues. It crosses the placental barrier, excreted in breast milk. At therapeutic concentrations of plasma protein binding small but increases with increasing concentration. Subjected to primary metabolism in the liver. Write mainly in the urine as glucuronides and sulfates. T1 / 2 is from 1 to 3 hours pheniramine pheniramine Cmax in plasma attained after about 1-2.5 hours, T1 / 2 pheniramine -… 16-19 h 70-83% of the dose excreted in urine as metabolites or unchanged . Phenylephrine phenylephrine is absorbed from the gastrointestinal tract. It is metabolized in the “first pass” through the intestinal wall and liver, so when administered phenylephrine hydrochloride characterized by limited bioavailability. Cmax in plasma is in the range from 45 minutes to 2 hours. Excreted by the kidneys almost entirely in the form of sulphate compounds. T1 / 2 of 2-3 hours. Ascorbic acid rapidly and completely absorbed from the gastrointestinal tract. Binding to plasma proteins – 25%. It is displayed in the form of metabolites in the urine. Ascorbic acid, adopted in excessive amounts, rapidly excreted unchanged in the urine.
Pregnancy and breast-feeding
Not recommended for use TeraFlyu® from colds and flu during pregnancy and lactation (breastfeeding).
Conditions of supply of pharmacies
Without recipe
side effects
Determining the frequency of side effects: very common (> 1/10), common (> 1/100 and
special instructions
To avoid liver toxicity drug should not be combined with the use of alcoholic beverages. Patients should consult a doctor if: -nablyudaetsya bronchial asthma, emphysema, chronic bronchitis fire; -simptomy not pass for 5 days followed by heavy fire fever continued for 3 days, a rash or persistent headache. These may be signs of more serious violations. Teraflyu® from influenza and colds comprising: -sucrose 20 g per sachet. This should be taken into account in patients with diabetes mellitus. Patients with rare hereditary problems such as fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency should not take Teraflyu® from colds and flu; -krasitel sunset yellow (E110). May cause allergic reactions; -sodium 28.3 mg sachet. This must be taken but the attention of patients on a diet with sodium restriction. Do not use the drug because of damaged packets. Effects on ability to drive vehicles and mechanisms Teraflyu® from the flu and colds can cause drowsiness, so during treatment is not recommended to drive vehicles or to engage in other activities requiring concentration of attention and speed of psychomotor reactions.
Storage conditions
The drug should be stored in reach of children at a temperature not higher than 25 ° C.
Dosing and Administration
Inside. The contents of one sachet dissolved in 1 cup of hot but not boiling water. Take hot. Repeated dose may be administered every 4-6 hours (no more than 3-4 doses over 24 hours). TeraFlyu® from the flu and colds can be used at any time of the day, but the best effect brings the drug before going to sleep at night. If no relief of symptoms is observed within 3 days after starting the drug, consult your doctor. Should not be used TeraFlyu® from colds and flu more than 5 days. Patients with impaired hepatic function or Gilbert’s syndrome is necessary to reduce the dose or increase the interval between doses. When severe renal insufficiency (creatinine clearance
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

GlaxoSmithKline Helsker

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