Terbinafine cream 1% 15g tube vertex

Description

Composition
Active substance:
1 g of cream contains: 10 mg terbinafine hydrochloride.
Excipients:
Benzyl alcohol, polysorbate 60 (Tween 60), sorbitan monostearate, cetyl alcohol, isopropyl myristate, cetyl palmitate, sodium hydroxide, purified water.
Description:
Uniform cream white with a faint characteristic odor.
Product form:
Cream for external application of 1% to 15 g or 30 g aluminum tubes or jars in 30 g of orange glass. Each jar or a tube together with instructions for use placed in a pile of cardboard.
Contraindications
Increased sensitivity to terbinafine or any of the inactive ingredients included in the formulation.
Precautions: hepatic and / or renal failure, alcoholism, depression of bone marrow hematopoiesis, tumors, metabolic disease, limb occlusive vascular disease, children up to 12 years (no sufficient clinical experience).
Pregnancy and lactation. teratogenic properties of terbinafine have been identified in experimental studies. To date, no reports of any malformation when terbinafine. However, as clinical experience with terbinafine in pregnant women is very limited, it should be used only on strict conditions.
Terbinafine is excreted in breast milk. However, in the case of nursing mother Terbinafine cream is absorbed through the skin a small amount of active substances, so adverse effects on the infant is unlikely.
Dosage
1 %
Indications
Prevention and treatment of mold, fungal skin infections, including mycosis stop ( “mushroom” of the foot), jock itch (tinea cruris), fungal infections of the skin smooth body (tinea corporis), caused by dermatophytes such as Trichophyton (including , T. rubrum, T. mentagrophytes, T. verrucosum, T. violaceum), Microsporum canis and Epidermophyton floccosum.
Yeast infections of the skin, mainly those caused genus Candida (e.g., Candida albicans), in particular diaper rash.
Pityriasis versicolor (Pityriasis versicolor), caused by Pityrosporum orbiculare (also known as Malassezia furfur).
Interaction with other drugs
Any drug interactions for Terbinafine cream is not known.
Overdose
No cases of overdose have been reported. If accidentally terbinafine cream be ingested, it is possible to expect development of the same side effects as an overdose of tablets (headache, nausea, epigastric pain and dizziness).
Treatment: activated charcoal, if necessary – symptomatic supportive therapy.
pharmachologic effect
Pharmacological group:
Antifungal agent.
Pharmacological properties:
Antifungal agent for topical application, with a broad spectrum of antifungal activity. Even in small concentrations it has a fungicidal effect of terbinafine against dermatophytes (Trychophyton rubrum, T. mentagrophytes, T. verrucosum, T. violaceum, T. tonsurans, Microsporum canis, Epidermophyton flocco-sum), mold (mainly C. albicans) and certain dimorphic fungi (Pityrosporum orbicu-lare). Activity against yeast fungi, depending on their type, may be a fungicidal or fungistatic.
Terbinafine specifically alters the early stage of the biosynthesis of sterols, occurring in fungi. This leads to a deficiency of ergosterol and intracellular accumulation of squalene, which causes death of fungal cells. Action terbinafine accomplished by inhibition of the enzyme squalene epoxidase located on the cell membrane of the fungus.
Terbinafine has no effect on cytochrome P450 system in humans and, accordingly, the metabolism of hormones or other drugs.
Pharmacokinetics:
When applied topically absorption – 5% has little systemic effect.
Conditions of supply of pharmacies
Without a prescription.
side effects
In the field application of the drug redness, itching or burning. Allergic reactions.
special instructions
Reducing the severity of the clinical manifestations usually noted in the first days of treatment. In the case of irregular or premature treatment termination are at risk of recurrent infection.
Terbinafine cream is for external use only. Avoid contact with eyes, as it may cause irritation. In case of accidental spraying into the eyes, they should immediately wash with running water, and in the case of persistent phenomena of irritation consult a doctor. With the development of allergic reactions need to remove the drug.
Storage conditions
In a dry place, protected from light, reach of children at a temperature not higher than 25 ° C.
Dosing and Administration
Outwardly.
Adults and children from 12 years:
Before applying the cream should be clean and dry the affected area. The cream is applied once or twice a day with a thin layer to the affected and surrounding skin areas and lightly rubbed. For infections involving intertrigo (under the breasts, interdigital spaces, between the buttocks, groin), lotions application site can cover the gauze, especially at night. With extensive body of fungal infections is recommended to apply the cream in tubes of 30 g
The average duration of treatment:
Ringworm of the body, legs: 1 week 1 time per day
Tinea pedis: 1 week 1 time per day
Skin candidiasis: 1-2 weeks 1 or 2 times a day
Pityriasis versicolor: 2 weeks 1 or 2 times a day
Reducing the severity of the clinical manifestations usually noted in the first days of treatment. In the case of irregular or premature treatment termination there is a risk of renewed infection. If after one or two weeks of treatment shows no sign of improving, there should be verification of the diagnosis.
The dosage regimen of the drug in the elderly is not different from the above.
Use of the drug in children. We do not recommend the use of this drug in children under 12 years old.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist