Tavegilum injection 1mg / ml 2 ml ampoules 5 pcs

Description

Composition
Active substance:
1 amp. (2 ml) Active ingredient: 2.68 mg clemastine fumarate (equivalent to 2 mg clemastine).
Excipients:
Sorbitol – 90 mg; Ethanol – 140 mg; propylene glycol – 600 mg; Sodium Citrate dihydrate – to pH 6.3; Water for injection – up to 2 mL.
Description:
A solution for in / in / m of transparent, colorless or of pale yellow to pale greenish-yellow color.
Product form:
Solution in / and the / m 2 ml – vials of glass (5) – plastic pallets (1), – the cardboard boxes.
Contraindications
– hypersensitivity; – pregnancy; – lactation; – MAO inhibitors; – diseases of the lower respiratory tract (including asthma); – fructose intolerance; – Children up to age 1 year. Intra-arterial injection of the drug is not permitted!
Precautions: in patients with stenosing peptic ulcer, piloroduodenalnoy obstruction, obstruction of the bladder neck and prostatic hypertrophy, accompanied by urinary retention, with increased intraocular pressure, hyperthyroidism, cardiovascular system, including hypertension.
Dosage
1 mg / ml
Indications
– prevention or treatment of allergic reactions and pseudoallergic (including the introduction of contrast agents, blood transfusion, the diagnostic application histamine); – angioneurotic edema, anaphylactic or anaphylactoid shock (as an additional means).
Interaction with other drugs
Tavegil® enhances the action of drugs, CNS depressants (hypnotics, sedatives, anxiolytics), m-holinoblokatorov and alcohol. Incompatible with simultaneous reception of MAO inhibitors.
Overdose
Symptoms. An overdose of antihistamines can lead to both depressing and a stimulating effect on the central nervous system, most often seen in children. Can also develop the phenomenon of anticholinergic action: dry mouth, fixed dilated pupils, flushing to the upper half of the body, tachycardia, disorders of the gastrointestinal tract (nausea, epigastric pain, vomiting). Treatment. Symptomatic therapy.
pharmachologic effect
Pharmacological group:
R06AA04
Pharmacodynamics:
N1- histamine receptor blocker, a derivative of ethanolamine. It has a strong antihistamine and antipruritic effect with rapid onset of action and duration of up to 12 hours, it prevents the development of vasodilation and smooth muscle contraction induced by histamine. With antiallergic action, reduces the permeability of blood vessels, capillaries, inhibits exudation and edema formation, reduces itching, has m-anticholinergic effect.
Pharmacokinetics:
Communication plasma protein is 95%. Excretion of plasma dwuhfazno corresponding T1 / 2 constitute 3.6 ± 0.9 hours and 37 ± 16 hours. Clemastine subject to significant metabolism in the liver. Metabolites mostly (45-65%) excreted through the kidneys in the urine; unmodified active substance found in urine in trace amounts only. During lactation a small amount of clemastine may enter breast milk.
Pregnancy and breast-feeding
Use of the drug during pregnancy and breast-feeding period is contraindicated.
Conditions of supply of pharmacies
On prescription
side effects
The classification of the frequency of occurrence of adverse reactions: very often (> 1/10); common (> 1/100,
special instructions
Effects on ability to drive vehicles and management mechanisms Clemastine has slight sedation (from mild to moderate in intensity), so the makers Tavegil® are advised to refrain from driving vehicles, using machinery, as well as other activities that require high concentration and speed of psychomotor reactions.
Storage conditions
At a temperature of 15 ° to 30 ° C. Keep out of the reach of children.
Dosing and Administration
Adults: 2 mg (2 ml), i.e. the content of 1 mg, 2 times daily (morning and evening). Since the drug is administered prophylactically in / jet slowly (within 2-3 min or more) at a dose of 2 mg just prior to the possible occurrence of anaphylactic reactions or reactions in response to the use of histamine. The solution preparation can be further diluted with isotonic sodium chloride or 5% glucose solution, sodium in a ratio of 1: 5. Babies: 0.025 mg / kg / day / m, dividing into 2 injections.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist