Table Ovenkor n / v 20mg pieces 30 1 + 1

Description

Composition
Active substance:
1 tablet contains: simvastatin 10 mg or 20 mg.
Product form:
Film-coated tablets 10 and 20 mg. 10, 30 tablets in blisters of PVC film and aluminum foil printed patent. 10, 14, 20, 28, 30, 40, 50 or 100 tablets in a polymeric container for medicines. One container or 1, 2, 3, 4, 5 or 10 contour cell packages together with instructions for use placed in a pile of cardboard.
Contraindications
– Hypersensitivity to simvastatin and other ingredients, as well as other statin drugs in series history. – Liver disease in its active phase, a persistent increase in “liver” enzymes of unknown etiology. – Porphyria. – Diseases of the skeletal muscles (myopathy). – Age 18 years.
Dosage
20 mg
Indications
Hypercholesterolemia: primary hypercholesterolemia, when poor diet low in cholesterol and other non-drug interventions in patients with increased risk of coronary atherosclerosis; combined hypercholesterolemia and hypertriglyceridemia, not correctable special diet and exercise. Coronary heart disease: for the prevention of myocardial infarction, to reduce the risk of death, reducing the risk of cardiovascular disorders, slow the progression of atherosclerosis of the coronary vessels, reducing the risk of revascularization procedures.
pharmachologic effect
Pharmacological group:
Lipid-lowering drugs – HMG-CoA reductase inhibitor.
Pharmacological properties:
Hypolipidemic agent derived synthetically from a fermentation product Aspergillus terreus, is an inactive lactone, is metabolized in the body to form the hydroxy-acid derivative. active metabolite inhibits 3-hydroxy-3-methyl-glyutaril-CoA reductase, the enzyme that catalyzes the initial reaction of formation of mevalonate izGMG-CoA. Since the conversion of HMG-CoA to mevalonate is an early stage of the synthesis of cholesterol simvastatin does not cause accumulation in the body potenuialno toxic sterols. HMG-CoA is readily metabolized to acetyl-CoA, which is involved in the synthesis of many processes in the body. It causes a decrease in blood plasma triglycerides, LDL and total cholesterol. Increases of high-density lipoproteins and decrease the ratio of LDL / HDL and total cholesterol / HDL. Onset of effect within 2 weeks from the start of reception, the maximum therapeutic effect is reached after 4-6 weeks. Action is maintained with continued treatment, at the termination of treatment of cholesterol is gradually returning to its original level.
Conditions of supply of pharmacies
Prescription.
Dosing and Administration
Prior to treatment, patients should appoint Ovenkorom standard hypolipidemic diet, which must be maintained throughout the course of treatment. Ovenkor should be taken 1 time per day in the evening, drinking plenty of water. Time of administration of the drug should not be associated with food intake. Ovenkora recommended dose for the treatment of hypercholesterolemia varies from 10 to 80 mg 1 time per day in the evening. The maximum daily dose – 80 mg. In the treatment of patients with coronary heart disease or a high risk of developing CHD Ovenkora effective doses are 20-40 mg per day. The recommended starting dose in such patsientov- 20 mg.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist