Table Migrenium n / v film 65mg 500mg + 20 units

$2.28

Table Migrenium n / v film 65mg 500mg + 20 units

Quantity:

Description

Composition
Active substance:
1 tablet contains: paracetamol – 0.500 g caffeine – 0.065 g
Excipients:
Potato starch, microcrystalline cellulose, croscarmellose sodium, giproloza (hydroxypropyl-cellulose), colloidal silicon dioxide, magnesium stearate, copovidone, talc, titanium dioxide, silicone emulsion (50% solution).
Description:
Tablets oval, biconvex forms coated white or almost white color with the mark on one side. In the cross-sectional two layers are visible. Color core uncoated white or nearly white.
Product form:
Tablets, film-coated 65 mg + 500 mg. At 10 or 20 tablets in a package together with instructions for use.
Contraindications
Hypersensitivity, severe liver and / or kidney failure, epilepsy, lack of glucose-6-phosphate dehydrogenase, old age, children’s age (12 years).
Precautions -Pregnancy, lactation, congenital hyperbilirubinemia (Gilbert syndrome, Dubin-Johnson and Rotor).
Dosage
65 mg + 500 mg
Indications
Pain (mild to moderate severity): headache, migraine, ossalgiya, myalgia, neuralgia, arthralgia, tuberculosis, toothache; feverish syndrome, “cold” diseases, acute respiratory viral infection (including the flu).
Interaction with other drugs
Enhances the action of monoamine oxidase inhibitors (MAO). Reduces the efficiency of uricosuric drugs.
Caffeine speeds up the absorption of ergotamine.
Under the influence of paracetamol during removal of chloramphenicol increases 5 times. Chronic administration of paracetamol can enhance the action of anticoagulants (bishydroxycoumarin). Simultaneous treatment with paracetamol and ethanol increases the risk of hepatotoxic effects and acute pancreatitis. Barbiturates, phenytoin, ethanol, rifampicin, phenylbutazone, tricyclic antidepressants and others. Stimulants microsomal oxidation increase the production of hydroxylated active metabolites, causing the possibility of severe intoxication with small overdoses. Inhibitors of microsomal oxidation (cimetidine) reduce the risk of hepatotoxicity. Metoclopramide and domperidone to increase, and cholestyramine reduces the absorption.
Overdose
Symptoms: paleness of the skin, loss of appetite, nausea, vomiting, sometimes with blood; gepatonekroz (severity of necrosis due to intoxication is directly dependent on the extent of overdose), gastralgia, agitation, anxiety, agitation, restlessness, confusion, delirium, dehydration, tachycardia, arrhythmia, hyperthermia, frequent urination, headache, tactile or pain sensitivity, tremors or muscle twitching; ringing in the ears, seizures (in acute overdose – tonic-clonic seizures), increased activity of “liver” transaminases, increase in prothrombin time; detailed clinical picture of liver damage is manifested after 1-6 days.
Treatment:. Donators administering to SH-groups and precursors of glutathione synthesis – methionine through 8-9chasov after the overdose and N-acetylcysteine ​​- 12 hours to prevent late hepatotoxic action performed gastric lavage.
pharmachologic effect
Pharmacological group:
Analgesic combined (non-narcotic analgesic agent means psihostimulirutee +).
Pharmacodynamics:
Migrenium – Combined drug action is determined by components in its composition.
Caffeine has a psychostimulant (stimulates the psychomotor centers of the brain), analeptic action, enhances the effect of analgesics, eliminates drowsiness and fatigue, increases physical and mental performance. Effect on the cardiovascular system: increases the frequency and strength of heart rate (HR), increases blood pressure (BP) hypotension (does not change the normal). Dilates the bronchi, bile ducts, blood vessels, skeletal muscle, heart, kidneys, constricts blood vessels of the abdomen. Decreases platelet aggregation. It stimulates the secretion of gastric glands, increases the basic metabolism, has moderate diuretic effect.
Paracetamol – antipyretic and analgesic action (due to inhibition of cyclooxygenase (COX) and inhibition of prostaglandin synthesis (Pg) affects the thermoregulatory center in the hypothalamus and holding of pain impulses in the central nervous system (CNS) drug blocks cyclooxygenase I and II preferably in CNS acting. on pain centers and thermoregulation. In inflamed tissues cellular peroxidase neutralize the effect of paracetamol on the cyclo-oxygenase, which explains the almost complete absence of his anti-eff . KTA drug has no adverse effect on the water-salt exchange (sodium and water retention) and the mucous of the gastrointestinal tract (GIT) due to lack of effect on prostaglandin synthesis in peripheral tissues possibility of formation of methemoglobin -. Unlikely.
Pharmacokinetics:
Caffeine and its water-soluble salts are well absorbed in the intestine (including the colon). The half-life (T1 / 2) is about 5 hours, in some individuals -. 10 hours main part demethylated and oxidized. About 10% excreted by the kidneys unchanged.
Paracetamol is rapidly and almost completely absorbed from the gastrointestinal tract. plasma concentration reaches a peak after 30-60 minutes. T1 / 2 plasma-1-4 hours. It is metabolized in the liver. Excreted in the urine mainly as esters with glucuronic acid and sulfuric acid; less than 5% is excreted unchanged.
Conditions of supply of pharmacies
Without recipe.
side effects
Allergic reactions (rash, angioedema, urticaria), dyspepsia (including nausea, epigastric pain). In rare cases – hemolytic anemia, thrombocytopenia, methemoglobinemia. With prolonged use of large doses – hepatotoxicity, pancytopenia, renal toxicity (renal colic, pyuria, interstitial nephritis, papillary necrosis).
special instructions
Excessive consumption of caffeine-containing products (coffee, tea) during treatment can cause symptoms of overdose.
With long-term (more than 1 week.) Treatment is necessary to monitor patterns of peripheral blood and functional state of the liver.
Without consulting a doctor take no more than 3 days in the treatment of febrile syndrome and no more than 5 days – at a painful syndrome.
Can change the results of the analyzes of doping control of athletes. Difficult to establish the diagnosis in acute “acute abdomen”. In patients with atopic asthma, hay fever, there is an increased risk of allergic reactions. During treatment should abandon the use of ethanol (increased risk of hepatotoxicity).
Storage conditions
In a dry, dark place at a temperature not higher than 25 ° C. In the reach of children.
Dosing and Administration
Inside, adults and children after 12 years – 2 tablets 4 times a day at intervals of not less than 4 hours maximum daily dose -. 8 tablets.
Duration of treatment – no more than 3 days (an antipyretic) and not more than 5 days (as an analgesic).
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

PROMOMED RUS

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