Sulfadimetoksin tab 500mg 10 pieces

Description

Composition
Active substance:
1 tablet contains: sulfadimetoksin – 200 mg or 500 mg.
Excipients:
Calcium stearate, gelatin, potato starch.
Product form:
Tablets of 200 mg or 500 mg.
Contraindications
Hypersensitivity, inhibition of bone marrow hematopoiesis, renal / hepatic failure, chronic heart failure, congenital deficiency of glucose-6-phosphate dehydrogenase deficiency, porphyria, azotemia, pregnancy, lactation, children under 3 years of age.
Dosage
500 mg
Indications
Infectious-inflammatory diseases caused by sensitive microflora: tonsillitis, bronchitis, pneumonia, sinusitis, otitis media, meningitis, dysentery, inflammatory diseases of the biliary and urinary tract infections, inflammation of the central nervous system, erysipelas, wound infection, trachoma.
Interaction with other drugs
Reduces the effectiveness of bactericidal antibiotics, acting only on the dividing microorganisms (including penicillins, cephalosporins).
Procaine, tetracaine and benzocaine reduced antibacterial activity.
Para-amino salicylic acid, barbiturates enhance the antimicrobial effect.
Salicylates increase the activity and toxicity.
Methotrexate and phenytoin increase the toxicity sulfadimetoksina.
Nonsteroidal anti-inflammatory drugs, thioacetazone, chloramphenicol enhance the toxic effect on blood (leukopenia, agranulocytosis).
Potentiates the effect of indirect anticoagulants, phenytoin, sulfonamides with hypoglycemic action; pyrazoline derivatives, salicylates and indomethacin to increase the free fraction of drug in the blood.
Reduces the effectiveness of oral contraceptives.
It enhances the metabolism of cyclosporin.
Myelotoxic drugs increase the expression gematotoksichnosti drug.
Overdose
Symptoms of overdose cases is unknown.
Treatment: gastric lavage, monitoring of vital functions, symptomatic therapy.
pharmachologic effect
Pharmacological group:
Antimicrobial agents of different groups.
Pharmacodynamics:
Antimicrobial bacteriostatic agent, sulfanilamide prolonged action. The mechanism of action is associated with a competitive antagonism with PABA, inhibition digidropteroatsintetazy, tetrahydrofolic acid synthesis disorder necessary for the synthesis of purines and pyrimidines. It is active against gram-positive and gram-negative microorganisms: Staphylococcus spp, Streptococcus spp.. including Streptococcus pneumoniae, Friedlander’s bacillus, Escherichia coli, Shigella dysenteria spp., Shigella flexneri spp., Shigella boydii spp., Shigella sonnei spp., Chlamydia trachomatis.
Pharmacokinetics:
After ingestion after 30 minutes is found in blood, time of maximum concentration – 8 -. 12 hours Unlike other members of the long acting sulphonamides poorly penetrates the blood-brain barrier and its concentration in the liquor is low. However, the blood-brain barrier permeability dramatically increases during inflammation of meningeal membranes. Therapeutic concentrations observed in adults when receiving 1 – 2 g per day 1, and 0.5 – 1 g – in the following days. The drug accumulates in the blood, primarily due to the high degree of binding to blood proteins (90 – 99%). Well distributed in organs and systems. It penetrates into the pleural fluid (60 – 90% of the concentration in the blood) in the biliary system, wherein the concentration of 1.5 – 4 times higher than in blood. Unlike other sulfonamides, primary metabolism carried out by way of microsomal glyukuronirovaniya – NADP-H-dependent and associated with cytochrome P450.
Return slowly, primarily due to the retention in the blood plasma proteins and due to the high degree of reabsorption in the renal tubules (93 – 97.5%). The blood contains 5 – 15% of acetylated metabolites in urine – 10 – 25% of the acetyl derivative and 75 – 90% – glucuronide sulfadimethoxine; the latter is highly soluble and does not cause the development of crystalluria. Acetyl derivative is not completely reabsorbed and excreted by the kidneys. After 24 h, displayed 20 – 44% of the dose after 48 hours – 56%, in 96 hours – up to 83.3%.
Conditions of supply of pharmacies
On prescription.
side effects
Headache, indigestion, leukopenia, agranulocytosis, nausea, vomiting, allergic reactions, cholestatic hepatitis.
special instructions
During therapy is recommended rich alkaline water, the control parameters of blood and urine.
Not the drug of choice I series.
Storage conditions
Store in the dark place at a temperature not higher than 25 ° C.
Dosing and Administration
Inside, 1 times a day, Day 1 – 1 – 2 g, and then – 0.5 – 1 g / day.
Babies from 3 to 12 years in the 1st day – 25 mg / kg / day, then – 12.5 mg / kg / day.
Children older than 12 years in the first day of 1 g, the next – 0.5 g
The course of treatment – 7-10 days.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist