Solpadein fast tab soluble. 8 pc

Description

Composition
Active substance:
Table 1 .: paracetamol 500 mg,
65 mg of caffeine.
Excipients:
Sorbitol, sodium saccharin, sodium hydrogencarbonate, povidone, sodium lauryl sulfate, dimethicone, citric acid, sodium carbonate.
Description:
Tablets soluble white, flat, with clipped circumferential edge and the notch on one side.
Product form:
Tablets soluble white, flat, with clipped circumferential edge and the notch on one side. 2 pcs. – laminated strips (4) – packs cardboard.
Contraindications
– increased sensitivity to the drug; – expressed human liver; – pronounced renal dysfunction; – arterial hypertension; – glaucoma; – sleep disturbances; – epilepsy; – Children up to age 12 years; – lack of sucrase / isomaltase, fructose intolerance, glucose-galactose malabsorption (contains sorbitol). Precautions should be used drug for benign hyperbilirubinemia (including Gilbert’s syndrome), viral hepatitis, alcoholic liver disease, deficiency of glucose-6-phosphate dehydrogenase, alcohol.
Indications
– headache; – migraine; – toothache; – neuralgia; – muscular and rheumatic pain; – painful menstruation; – a sore throat; – to reduce elevated body temperature and symptomatic treatment of colds and flu.
Interaction with other drugs
When taken regularly for a long time the drug enhances the effect of indirect anticoagulants (warfarin and other coumarin), which increases the risk of bleeding. Episodic receiving a single dose of the drug has no significant effect on the action of anticoagulants. The preparation enhances the action of MAO inhibitors. Barbiturates, carbamazepine, phenytoin, primidone, ethanol, rifampicin, phenylbutazone, Hypericum drugs, tricyclic antidepressants and other inducers of microsomal oxidation increase the production of hydroxylated active metabolites, causing the possibility of severe liver disease with small overdose of paracetamol (5 g, and more). Inhibitors of microsomal oxidation (cimetidine) reduce the risk of hepatotoxicity. Under the influence of paracetamol during removal of chloramphenicol increases 5 times. Caffeine speeds up the absorption of ergotamine. Simultaneous treatment with paracetamol and alcoholic beverages increases the risk of hepatotoxic effects and acute pancreatitis. Metoclopramide and domperidone to increase, and cholestyramine reduces the rate of absorption of paracetamol. The drug may reduce the effectiveness of uricosuric drugs.
Overdose
Symptoms related to paracetamol: within 24 hours are possible pallor of the skin, nausea, vomiting, anorexia, stomach pain; 1-2 days may manifest symptoms of liver disease (pain in the liver area, elevated liver enzymes). Possible violation of carbohydrate metabolism and signs of metabolic acidosis. In adult patients, liver damage develops after receiving more than 10 g of paracetamol. In the presence of factors influencing the paracetamol liver toxicity, liver damage possibly after reception of paracetamol in an amount of 5 g or more. In severe cases of overdose as a result of hepatic encephalopathy may develop failure, bleeding, hypoglycemia, brain edema, including death. Perhaps the development of acute renal failure with acute tubular necrosis, the characteristic features of which is a pain in the lumbar region, hematuria, proteinuria, with severe liver disease may be absent. There are reports of cardiac rhythm disorders, pancreatitis. Treatment: If you suspect an overdose, even in the absence of symptoms expressed, you must stop using the product immediately and seek medical help. Within 1 h after the overdose recommended gastric lavage and intake ehnterosorbentov (activated carbon, Polyphepanum). It should determine the concentration of paracetamol in plasma, but no sooner than 4 hours after the overdose (earlier results are unreliable). Introduction acetylcysteine ​​within 24 hours after the overdose. Maximum protective action is provided during the first 8 hours after the overdose with time antidote efficiency sharply falls. acetylcysteine ​​administered in / if necessary. In the absence of vomiting to the patient admission to the hospital may use methionine. The need for additional therapeutic activities (further introduction of methionine in / introduction acetylcysteine) is determined depending on the blood concentration of paracetamol, as well as on the time elapsed after administration. Treatment of patients with serious hepatic dysfunction at 24 hours after ingestion of paracetamol should be carried out together with specialists or poison control center specialized branch of liver diseases. Symptoms related to caffeine: epigastric pain, vomiting, frequent urination, tachycardia, arrhythmia, CNS stimulation (insomnia, anxiety, agitation, anxiety, increased neuro-reflex excitability, tremors, and convulsions). However, it should be borne in mind that the appearance of clinically significant symptoms of caffeine overdose while taking this drug is always associated with severe liver disease on the background of paracetamol overdose. Treatment: the specific antidote is available. Treatment includes supportive measures, such as drinking plenty of fluids and to maintain vital signs. Within 1 hour to 4 hours after the overdose recommended administration of activated charcoal. To reduce the effects of caffeine overdose on the central nervous system recommended administering sedatives / in.
pharmachologic effect
Pharmacological group:
N02BE71
Pharmacodynamics:
Analgesic-antipyretic combined composition comprises a combination of two active ingredients: acetaminophen and caffeine. It has antipyretic and analgesic effect. Paracetamol blocks COX in the central nervous system, affecting the pain and thermoregulatory centers (in inflamed tissues cellular peroxidase neutralize the effect of paracetamol on COX), which explains the almost complete absence of anti-inflammatory effect. No effect on prostaglandin synthesis in peripheral tissues causes lack of a negative effect on water-salt exchange (sodium and water retention), and gastrointestinal mucosa. Caffeine stimulates the psychomotor centers of the brain, has analeptic action, enhances the effect of analgesics, eliminates drowsiness and fatigue, increases physical and mental performance.
Pharmacokinetics:
Paracetamol is rapidly and almost completely absorbed from the gastrointestinal tract, the distribution in the body fluids is relatively evenly. Binding to plasma proteins paracetamol minimally at a therapeutic concentration. Paracetamol is metabolized by the liver and excreted in the urine as glucuronide and sulfate metabolites – less than 5% is excreted unchanged. T1 / 2 for receiving a therapeutic dose amounts to 2-3 hours. Caffeine is rapidly absorbed from the gastrointestinal tract and distributed throughout the body. Caffeine is almost completely metabolized in the liver by oxidation and demethylation as metabolites that are excreted in the urine. T1 / 2 of 4-9 hours.
Pregnancy and breast-feeding
Fast Solpadein drug contains caffeine. When receiving the caffeine there is a high risk of having a baby with low birth weight, the risk of spontaneous abortion. Getting into the breast milk, caffeine can have a stimulating effect on the child who is breastfed. Fast Solpadein preparation should not be used during pregnancy and lactation (breast feeding).
Conditions of supply of pharmacies
Without recipe
side effects
The recommended dosage is generally well tolerated drug. Determining the frequency of side effects: very common (> 1/10), common (> 1/100 and
special instructions
If you are taking the drug improved condition is not observed, or headache becomes constant, it is necessary to consult a doctor. During the drug is not recommended excessive consumption of caffeine-containing food products (including tea, coffee), as it can lead to agitation, irritability, sleep disturbances, headaches, disorders of the gastrointestinal tract, tachycardia, cardiac arrhythmia. In the case of prolonged use at high doses necessary to monitor the blood picture. Glutathione deficiency due to eating disorders, cystic fibrosis, HIV infection, starvation, depletion makes the possibility of severe liver disease with small overdose of paracetamol (5 g, and more). The drug should not be taken concomitantly with other drugs paratsetamolsoderzhaschimi. To avoid liver toxicity of paracetamol should not be combined with the admission of alcoholic beverages, as well as to make people prone to chronic alcohol consumption. In patients suffering from atopic asthma, hay fever, there is an increased risk of allergic reactions. Patients who observe a salt-free or low-salt diet, the calculation of the daily intake of salt should be taken into account the sodium content in the tablet (427 mg). In the analysis, the determination of uric acid and blood glucose should inform your doctor about taking medication. Fast solpadein can change the results of the analyzes of doping control of athletes. When the consumption of sodium hydrogen carbonate in high doses may develop disorders of the gastrointestinal tract, including belching, nausea; it is also possible the development of hypernatremia. In such cases it is necessary to control fluid and electrolyte balance and apply the appropriate patient management tactics.
Storage conditions
The drug should be stored in reach of children at a temperature not higher than 25 ° C.
Dosing and Administration
Tablets Solpadein Fast before ingestion should be dissolved in no less than 100 ml (half a cup) of water. Adults (including the elderly) and children over 12 years: 1-2 tabs. 3-4 times / day, if necessary. The interval between doses of at least 4 hours maximum single dose -. 2 pi, the maximum daily dose -. Table 8. The drug is not recommended to use more than 5 days when administered as an analgesic, and more than 3 days as antipyretic without prescription and a physician monitoring. Increasing the daily dose or duration of treatment is possible only under medical supervision.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist