Solpadein fast tab n / a film about 24 pc

$6.99

Solpadein fast tab n / a film about 24 pc

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Description

Composition
Active substance:
1 tablet contains paracetamol 500 mg, caffeine 65 mg.
Excipients:
Starch pregelatinized 50 mg corn starch 41,4 mg, 2 mg povidone, potassium sorbate 0.6 mg Talc 15 mg Stearic acid 5 mg, 10 mg croscarmellose sodium, 5 mg of hypromellose, triacetin 1 mg.
Description:
The white film-coated tablets kapsulovidnoy forms a flat edge. On one side of the sign is applied in the form of tablets embossing a triangle and “+”.
Product form:
Tablets, film-coated.
12 tablets in PVC / aluminum blister. 1 or 2 blisters together with instructions for use placed in a cardboard box.
Contraindications
– increased sensitivity to the drug – expressed human liver or renal function – hypertension – glaucoma, sleep disorders – children up to 12 years – Epilepsy
Carefully:
Used with caution in benign hyperbilirubinemia (including Gilbert’s syndrome), viral hepatitis, alcoholic liver disease, deficiency of glucose-6-phosphate dehydrogenase, alcohol.
Indications
“Solpadein Fast” is used to relieve headache, migraine, toothache, backache, neuralgia, muscular and rheumatic pain, painful menstruation, pain in the throat. “Fast Solpadein” is also used for the symptomatic treatment of colds and flu, reducing elevated body temperature.
Interaction with other drugs
When taken regularly for a long time the drug enhances the effect of indirect anticoagulants (warfarin and other coumarin), which increases the risk of bleeding. Episodic receiving a single dose of the drug has no significant effect on the action of anticoagulants. It enhances the action of MAO inhibitors. Barbiturates, carbamazepine, phenytoin, primidone, ethanol, rifampicin, phenylbutazone, Hypericum drugs, tricyclic antidepressants and other inducers of microsomal oxidation increase the production of hydroxylated active metabolites, causing the possibility of severe liver disease with small overdose of paracetamol (5 g, and more). Inhibitors of microsomal liver enzymes (cimetidine) reduce the risk of hepatotoxicity.
Under the influence of paracetamol during removal of chloramphenicol increases 5 times. Caffeine speeds up the absorption of ergotamine. Simultaneous treatment with paracetamol and alcoholic beverages increases the risk of liver injury and acute pancreatitis.
Metoclopramide and domperidone to increase, and cholestyramine reduces the rate of absorption of paracetamol. The drug may reduce the effectiveness of uricosuric drugs.
Overdose
Symptoms (caused by paracetamol): during the first 24 hours after the overdose – nausea, vomiting, stomach pain, skin pallor, anorexia. After 1-2 days determined signs of liver disease (pain in the liver area, increased activity “liver” enzymes). Perhaps the development of glucose metabolism and metabolic acidosis. In adult patients, liver damage develops after receiving more than 10 g of paracetamol. In the presence of factors influencing the paracetamol liver toxicity (see. The section “Interaction with other medications,” “special instructions”) liver possible after receiving more than 5 grams of paracetamol. In severe cases of overdose as a result of hepatic encephalopathy may develop failure (impaired brain function), bleeding, hypoglycemia, brain edema, including death. May develop acute renal failure, acute tubular necrosis, the characteristic features of which is pain in the lumbar region, haematuria (impurity blood or red blood cells in the urine), proteinuria (high protein content in the urine), with severe liver damage can be absent. Cases of cardiac arrhythmia, pancreatitis.
Treatment: If you suspect an overdose, even in the absence of symptoms expressed, you must stop using the product immediately and seek medical help. Within 1 hour after overdose recommended gastric lavage and intake ehnterosorbentov (activated carbon, Polyphepanum). It should determine the level of paracetamol in plasma, but no sooner than 4 hours after the overdose (earlier results are unreliable). Introduction acetylcysteine ​​within 24 hours after the overdose.
Maximum protective action is provided during the first 8 hours after the overdose with time antidote efficiency sharply falls. If necessary acetylcysteine ​​is administered intravenously. In the absence of vomiting to the patient admission to the hospital may use methionine. The need for additional therapeutic activities (further introduction of methionine in / introduction acetylcysteine) is determined depending on the blood concentration of paracetamol, as well as on the time elapsed after administration. Treatment of patients with serious hepatic dysfunction at 24 hours after ingestion of paracetamol should be carried out together with specialists or poison control center specialized branch of liver diseases.
Symptoms (due to caffeine): epigastric pain, vomiting, frequent urination, tachycardia, arrhythmia, CNS stimulation (insomnia, anxiety, agitation, anxiety, increased neuro-reflex excitability, tremors, and convulsions). However, it should be borne in mind that the appearance of clinically significant symptoms of caffeine overdose while taking this drug is always associated with severe liver disease on the background of paracetamol overdose.
Treatment: the specific antidote is available. Treatment includes supportive measures, such as drinking plenty of fluids and to maintain vital signs. Within from 1 hour to 4 hours after the overdose recommended administration of activated charcoal. To reduce the effects of caffeine overdose on the central nervous system sedatives recommended administration intravenously.
pharmachologic effect
Pharmacological group:
Non-narcotic analgesic agent (non-narcotic analgesic + psychostimulant agent).
Pharmacological properties:
The drug has analgesic and antipyretic effect. “Fast Solpadein” contains a combination of two active ingredients: acetaminophen and caffeine. Paracetamol blocks cyclooxygenase (COX) in the central nervous system (CNS), acting on the pain and thermoregulatory centers (in inflamed tissues cellular peroxidase neutralize the effect of paracetamol on COX), which explains the almost complete absence of anti-inflammatory effect. No effect on the synthesis of Pg in peripheral tissues causes lack of a negative effect on water-salt exchange (sodium and water retention) and the mucous of the gastrointestinal tract. Caffeine stimulates the psychomotor centers of the brain, has analeptic action, enhances the effect of analgesics, eliminates drowsiness and fatigue, increases physical and mental performance.
Pharmacokinetics:
Paracetamol is rapidly and almost completely absorbed from the gastrointestinal tract, the distribution in the body fluids is relatively evenly.
Binding to plasma proteins paracetamol minimally at a therapeutic concentration.
Paracetamol is metabolized by the liver and excreted in the urine as glucuronide and sulfate metabolites – less than 5% is excreted as unchanged paracetamol. The half-life at the therapeutic dose is 2-3 hours.
Caffeine is rapidly absorbed from the gastrointestinal tract and distributed throughout the body.
Caffeine is almost completely metabolized in the liver by oxidation and demethylation as metabolites that are excreted in the urine. The half-life is 4-9 hours.
Pregnancy and breast-feeding
Drug “Solpadein Fast” contains caffeine. When receiving the caffeine there is a high risk of having a baby with low birth weight, the risk of spontaneous abortion.
Getting into the breast milk, caffeine can have a stimulating effect on the child who is breastfed.
Drug “Solpadein Fast” should not be taken during pregnancy and lactation.
Conditions of supply of pharmacies
Without recipe.
side effects
The recommended dosage is generally well tolerated drug. The following side effects are revealed spontaneously during post-marketing the drug.
Side effects are classified according to organ system and frequency. The frequency of side effects is defined as follows: very often (greater than or equal to 1/10), often (greater than or equal to 1/100 and less than 1/10) infrequently (greater than or equal to 1/1000 and less than 1/100), rare ( greater than or equal to 1/10 000 and less than 1/1000) and very rare (greater than or equal to 1/100 and less than 1/10 000 000).
Allergic reactions:
Very rarely – a skin rash, angioedema (angioedema), Stevens-Johnson syndrome, anaphylaxis;
From hemopoiesis system:
Very rarely – leukopenia, thrombocytopenia, methemoglobinemia, agranulocytosis, hemolytic anemia;
The respiratory system:
Very rarely – bronchospasm (in patients with hypersensitivity to aspirin and other nonsteroidal anti-inflammatory drugs);
On the part of the hepatobiliary system:
Very rarely – liver dysfunction.
With prolonged use at high doses increases the likelihood of hepatotoxicity, nephrotoxicity and pancytopenia. Also in cases of prolonged use at high doses necessary to monitor the blood picture.
Caffeine
The reaction may occur in the form of dyspeptic disorders (including nausea, epigastric pain), anxiety, dizziness, sleep disorders, tachycardias. If excessive use of caffeine-containing foods (tea, coffee, etc.) During treatment may cause restlessness, anxiety, irritability, insomnia, headaches, disorders of the gastrointestinal tract, tachycardia, cardiac arrhythmia.
If you experience any of these side effects, stop taking the drug and consult a doctor immediately.
special instructions
If you are taking the drug improved condition is not observed, or headache becomes constant, it is necessary to consult a doctor.
During the administration of the drug is not recommended to excessive consumption of caffeine-containing foods (tea, coffee, etc.), As this can lead to restlessness, anxiety, irritability, insomnia, headaches, disorders of the gastrointestinal tract, tachycardia, cardiac arrhythmias .
Glutathione deficiency due to eating disorders, cystic fibrosis, HIV infection, starvation, depletion causes the possibility of severe liver disease with small overdose of paracetamol (5 g, and more).
The drug should not be taken concomitantly with other drugs paratsetamolsoderzhaschimi.
AVOID toxic liver damage paracetamol does not should be combined with drinking alcohol, as well as take people prone to chronic alcohol consumption.
In patients with atopic asthma, hay fever, there is an increased risk of allergic reactions.
In patients with renal and hepatic insufficiency, the use of the drug with caution and only after consulting your doctor. While taking the drug in patients with non-alcoholic cirrhosis of the liver have a high risk of overdose.
In the analysis, the determination of uric acid and blood glucose should inform your doctor about taking medication.
Can change the results of the analyzes of doping control of athletes.
Storage conditions
Store at a temperature not higher than 25 C. Keep out of reach of children.
Dosing and Administration
Adults (including the elderly) and children over 12 years: Usually 1-2 tablets 3-4 times a day, if necessary. The interval between doses is not less than 4 hours. The maximum single dose – 2 tablets with a maximum daily dose – 8 tablets.
The drug is not recommended for more than five days as an analgesic, and more than three days as an antipyretic without an appointment and supervision of a physician. Increasing the daily dose or duration of treatment is possible only under medical supervision. Do not exceed this dose. In case of overdose contact your doctor immediately, even if you feel well.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

solpadein

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