Sintomitsina suppositories vaginas. 250mg 10 pieces

Description

Composition Active substance 1 suppository contains: D, L-chloramphenicol (sintomitsina) – 0.25 g Excipients: colloidal silicon dioxide (Aerosil) – 0.009 g of polysorbate (Tween 80) – 0.009 g of the solid fat. Product: 250 mg Suppositories. Packing 10 pcs. Hypersensitivity to the drug, inhibition of bone marrow hematopoiesis, acute intermittent porphyria, deficiency of glucose-6-phosphate dehydrogenase, liver and / or kidney failure, fungal diseases of the vagina. Do not use the drug in girls before sexual debut. Dosage 250 mg Indications Vaginitis, cervicitis caused by microorganisms susceptible to the drug. Prevention of inflammatory diseases in gynecology before invasive procedures (abortion, cervical diathermocoagulation, hysterography, before and after establishing the IUD). Interaction with other drugs Barbiturates accelerating biotransformation reduce the concentration and duration of effect. It reduces the antibacterial effect of penicillins and cephalosporins. While the use of erythromycin, clindamycin, lincomycin noted the mutual weakening of the action. With the simultaneous use of alcohol can disulfiramopodobnye reaction. Overdosing When intravaginal application cases of drug overdose was noted. The drugs Group: Antibacterial agents. Pharmacodynamics: Chloramphenicol – bacteriostatic antibiotic with a wide spectrum of action violates the process of protein synthesis in the microbial cell (having a good lipophilicity penetrates through the cell membrane bacteria and reversibly binds to the 50S subunit of the bacterial ribosome, which is delayed movement of amino acids to growing peptide chains, which leads to violation of protein synthesis). It is active against many Gram-positive and Gram-negative bacteria, pathogens festering, intestinal infections: Escherichia coli, Shigella dysenteria, Shigella flexneri, Shigella boydii, Shigella sonnei, Salmonella spp. (Including Salmonella typhi, Salmonella paratyphi), Staphylococcus spp., Streptococcus spp. (Including Streptococcus pneumoniae), Neisseria gonorrhoeae, a number of strains of Proteus spp., Burkholderia pseudomallei, Rickettsia spp., Treponema spp., Leptospira spp., Chlamydia spp. (Including Chlamydia trachomatis), Coxiella burnetii, Ehrlichia canis, Bacteroides fragilis, Klebsiella pneumoniae, Haemophilus influenzae. He acts on the acid-fast bacteria (including Mycobacterium tuberculosis), anaerobes, methicillin-resistant strains of Staphylococcus spp., Acinetobacter spp., Enterobacter spp., Serratia marcescens, indolpolozhitelnye strains of Proteus spp., Pseudomonas aeruginosa spp., Protozoa and fungi . Resistance of microorganisms is slow. Pharmacokinetics When intravaginal administration is practically not absorbed and has no systemic action. Pregnancy and lactation The drug is contraindicated during pregnancy and lactation. Conditions of supply of pharmacies by prescription. Adverse reactions may be allergic reactions, suppression of hemopoiesis. Indigestion, dermatitis, suppression of normal microflora, secondary fungal infection. Burning sensation when urinating or frequent urination, itching, burning pain or redness of the mucous membrane of the vulva, burning or irritation of the penis in the sexual partner, dysbiosis vagina. Cautions During treatment requires systematic monitoring of peripheral blood picture. Patients receiving the drug should refrain from activities requiring increased attention and rapid mental and motor reactions (driving, high-precision control mechanisms). Storage Store in a dry, dark place at a temperature not higher than 15 ° C. Dosing and dose Intravaginal. Pre-releasing suppository contour of the package with scissors (cutting the film along a contour of a suppository), administered lying on back, as far as possible into the vagina of one suppository 2-3 times per day. The maximum daily dose – 4 suppository. The average duration of treatment is 8-10 days, if necessary, and good endurance can be increased to 14 days. Info appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist