Sintomitsina linim. 10% 25d Nizhpharm tuba

Description

Composition
Active substance:
1 g of chloramphenicol liniment contains [D, L] (sintomitsina) – 100 mg ;.
Excipients:
Castor oil – 200.0 mg, emulsifier № 1 – 30,0-50,0 mg Sorbic Acid – 2.0 mg Ethanol – 8.1 mg based on 96% alcohol, sodium carmellose – 18.4 mg based on the degree of polymerization of 450 – 500, water – up to 1 g
Description:
Liniment white or white color with a yellowish shade, with a faint characteristic odor.
Product form:
Liniment 10%. 25 g aluminum tubes. 1 the tube together with instructions for medical use of the formulation was put in a pile of cardboard.
Contraindications
Individual intolerance, inhibition of bone marrow hematopoiesis, acute intermittent porphyria, deficiency of glucose-6-phosphate dehydrogenase, liver and / or kidney failure, skin diseases (fungal lesions, psoriasis, eczema), pregnancy, lactation, neonatal period (up to 4 weeks.).
In the absence of osmotic activity (basis: oil, emulsifier) ​​is not recommended during the first phase of wound healing (excessive suppuration expressed tissue edema, pain and the presence of necrotic tissue).
Dosage
10 %
Indications
Infected wounds during phase II of wound healing (no pus, necrotic tissue), nonhealing trophic ulcers, burns 2-3 degrees.
Interaction with other drugs
When applied simultaneously with erythromycin, clindamycin, lincomycin possibly weakening the mutual action due to the fact that chloramphenicol can displace these drugs from a bound state or inhibit their binding to the 50S subunit of bacterial ribosomes. It reduces the antibacterial effect of penicillins and cephalosporins.
pharmachologic effect
Pharmacological group:
Antibiotic.
Pharmacological properties:
The active ingredient of the drug is chloramphenicol – a broad spectrum antibiotic having a high antibacterial activity against the pathogen wound infections and various forms of inflammatory processes.
Chloramphenicol – bacteriostatic antibiotic penalized protein synthesis in the microbial cell (having a high lipophilicity, penetrates through the cell membrane bacteria and reversibly binds to the subunit 50S bacterial ribosomes thereby delayed amino movement to the growing peptide chains, which leads to disruption of formation of the peptide bonds and synthesis squirrel). It is active against most strains of Gram-positive and Gram-negative organisms that are resistant to penicillin, tetracycline, sulfonamides. Promotes cleansing and healing of burn wounds and trophic ulcers, accelerates epithelialization.
Pharmacokinetics:
The degree of absorption into the systemic circulation after the application of the preparation to the skin, wounds or mucous membranes unknown.
Conditions of supply of pharmacies
Without recipe.
side effects
Allergic reactions: skin rash, angioedema.
From the side of hematopoiesis: rarely – reticulocytopenia, leukopenia, granulocytopenia, thrombocytopenia, erythropenia, aplastic anemia, agranulocytosis.
special instructions
In the course of treatment requires systematic monitoring of peripheral blood picture.
Adverse effects on the fetus during pregnancy and breastfeeding is not revealed.
When applied over large surface with simultaneous reception ethanol development disulfiramopodobnyh reactions (redness of the skin, tachycardia, nausea, vomiting, cough reflex, convulsions).
Storage conditions
At a temperature of not higher than 20 ° C.
Keep out of the reach of children.
Dosing and Administration
Outwardly. After the surgical treatment of wounds and burns sintomitsina liniment applied directly on the wound surface and then impose a sterile gauze bandage or sintomitsina liniment is applied to the dressing, and then wound. Tampons with linimentom loosely filled cavity purulent wounds after surgical treatment, and gauze with turundy linimentom sintomitsina administered in tracts. In the treatment of wounds and burns in the 2nd phase – 1 every 1-3 days depending on the healing dynamics.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist