Sedalgin plus 20 pc Table

$5.00

Sedalgin plus 20 pc Table

Quantity:

Description

Composition
Active substance:
1 tablet contains: metamizole sodium 500 mg, caffeine 50 mg thiamine hydrochloride 38.75 mg.
Excipients:
Cellulose microcrystalline 45.75 mg, 11.00 mg wheat starch, gelatin, 4.00 mg colloidal silica 2.50 mg Talc 12.00 mg Magnesium stearate 6.00 mg.
Description:
Round flat tablets from white to almost white color, with a bilateral facet and scored on one side.
Product form:
Tablets. 10 tablets in the blister of a three-layer PVC / PVDC / PVC film, or a two-layer PVC / PVDC film and aluminum foil. 1 or 2 blisters together with instructions for use in a cardboard package.
Contraindications
Hypersensitivity to the drug.
Hypersensitivity to other pyrazolone derivatives – phenylbutazone.
Severe hepatic and / or renal failure.
Bronchospasm.
Deficiency of glucose-6-phosphate dehydrogenase (glucose-B-phosphate dehydrogenase enzyme congenital deficiency syndrome).
Diseases of the blood system.
Insomnia.
Uncontrolled hypertension.
Expressed atherosclerosis.
Increased intraocular pressure.
Pregnancy and breast-feeding.
Children’s age (12 years).
Precautions – dysfunction of the liver and / or kidney.
Indications
Moderately or weakly expressed pain syndrome of different genesis: headache (including migraine), toothache, neuralgia, muscle pain (myalgia), joint pain (arthralgia), radicular syndrome, menstrual pain (algomenorrhea).
Febrile syndrome in “cold” and other infectious and inflammatory diseases (for diagnosis).
Interaction with other drugs
Simultaneous application Metamizole (dipyrone) with other non-narcotic analgesics, non-steroidal anti-inflammatory drugs may lead to mutual reinforcement of toxic effects.
Tricyclic antidepressants, oral contraceptives, allopurinol violate Metamizole metabolism in the liver and increase its toxicity.
Barbiturates, phenylbutazone (phenylbutazone) and other inducers of microsomal liver enzymes weaken the effect Metamizole. Simultaneous application Metamizole cyclosporin reduces the concentration of the latter in the blood.
Sedatives and tranquilizers enhance analgesic effect Metamizole.
Overdose
Symptoms include nausea and vomiting, sometimes with blood, pain in the stomach, mental and motor agitation, tachycardia, cardiac arrhythmias may decrease or increase diuresis, convulsions, anxiety, confusion, delirium, dehydration, pyrexia, headache, tactile or sensitivity to pain, tremor or muscle twitching; ringing in the ears, seizures (in acute overdose – tonic-clonic).
Treatment: you should immediately seek medical help. The victim must gastric lavage, assign adsorbents (e.g., activated carbon), laxatives medicines. If necessary symptomatic treatment (haemorrhagic gastritis – administering antacid drugs and gastric lavage with ice-cold 0.9% sodium chloride solution, maintaining ventilation and oxygenation, in epileptic seizures – intravenous diazepam, phenobarbital or phenytoin; maintain fluid balance and salts).
pharmachologic effect
Pharmacological group:
Analgesic combined (non-narcotic analgesic agent means psihostimulirutee + + vitamin).
Pharmacodynamics:
Combination drug has analgesic, antipyretic and anti-inflammatory effect.
Metamizole a pyrazolone derivative, and has analgesic, antipyretic and weak anti-inflammatory action, the mechanism of which is associated with inhibition of prostaglandin synthesis by inhibiting cyclooxygenase.
Caffeine – stimulates the central nervous system (CNS), primarily on the cerebral cortex, respiratory and vasomotor centers. Enhances mental and physical performance, reduces sleepiness, fatigue. Caffeine increases the permeability gistogematicheskih barriers and increases the bioavailability of non-narcotic analgesics, thereby enhancing the therapeutic effect.
Thiamine (vitamin B) is involved in metabolism and improves neuroreflex conductivity.
Pharmacokinetics:
The pharmacokinetic properties of the drug Sedalgin Plus depend on the pharmacokinetics of the components included in its composition.
Metamizole.
Metamizole rapidly and completely absorbed from the gastrointestinal tract, reaching peak plasma concentration after an average of 60-90 minutes after administration. Bound to plasma proteins and undergoes metabolism in the liver. By way non-enzymatic hydrolysis cleaved to 4 metilaminoantipirina with further metabolism via active 4-aminoantipyrine and 4-atsetilaminoantipirina – the major metabolite, 90% of which is eliminated via the kidneys and 10% – in the bile with a half-life of about 10 hours.
Caffeine.
Caffeine, part of the drug is almost completely absorbed, the maximum plasma concentration is determined after 30-40 minutes. Quickly passes through the blood-brain and the placental barrier, enters the breast milk is discharged (including in the form of metabolites) in the kidneys.
Thiamine.
Absorption – high, all over the small intestine. Before absorption of thiamine hydrochloride is released from the bound state by digestive enzymes. The blood concentration of thiamine hydrochloride relatively low.
The plasma free thiamine found predominantly in leukocytes and erythrocytes – its phosphoric esters. Half of the total quantity contained in striated muscle (including myocardium) and about 40% -in internal organs.
Phosphorylation occurs in the liver. The most active phosphoric ester is tiamin- diphosphate having coenzyme activity. It accumulates mainly in the liver, heart, brain, kidneys, and spleen. Displayed through the intestines and kidneys.
Conditions of supply of pharmacies
Without recipe.
side effects
On the part of the gastrointestinal tract: loss of appetite, nausea, vomiting, cholestasis, jaundice.
From the side of hematopoiesis: thrombocytopenia, leukopenia, agranulocytosis, hemolytic anemia, purpura.
On the part of the central nervous system: insomnia, dizziness, irritability. Cardio-vascular system: feel palpitations, cardiac arrhythmias. Allergic reactions: skin rash, itching, flushing, angioedema, anaphylactic shock; bronchospasm.
Of all the side effects should be reported to your doctor.
special instructions
Excessive consumption of caffeine-containing products (tea, coffee) against the background of treatment can cause symptoms of overdose.
With care and use under medical supervision in patients with impaired liver or kidney function.
Simultaneous use of the drug with the alcoholic beverages is not recommended.
In patients with atopic asthma, hay fever, there is an increased risk of developing hypersensitivity reactions.
Effects on ability to drive and use machines.
Caution should be exercised when driving and operating machinery that require high concentration and speed of psychomotor reactions, because when taking the drug may develop dizziness.
Storage conditions
Store at a temperature not higher than 25 C.
Keep out of the reach of children!.
Dosing and Administration
Inside after eating 1 tablet 2-3 times in the first half of the day. The maximum single dose for adults and adolescents from 16 years – 2 tablets, maximum daily dose – 6 tablets no more than 1 to 2 days.
Children aged 12 to 16 years – half or one tablet 2-3 times a day, the maximum daily dose – 4 tablets.
Duration – not more than 5 days when administered as an analgesic and 3 days as an antipyretic.
If symptoms continue or worsen, consult your doctor. Increasing the daily dose or duration of treatment is possible only under medical supervision.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

TEVA

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