Riboxinum injection of 2% 10ml amp 10 pcs

$2.02

Riboxinum injection of 2% 10ml amp 10 pcs

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Quantity:

Description

Composition
Active substance:
1 ml of solution contains: inosine (Riboxinum) – 20 mg.
Excipients:
Methenamine (hexamethylenetetramine) – 2 mg, 1M sodium hydroxide solution (sodium hydroxide solution) – up to a pH of 7,8-8,6, water for injection – up to 1 ml.
Description:
Transparent colorless or weakly colored liquid.
Product form:
A solution for intravenous administration of 20 mg / ml. 5 ml or 10 ml in neutral glass ampoules. 5 ampoules in blisters of PVC film. 1 or 2 outline package placed in a pile of cardboard.
Contraindications
Hypersensitivity to the drug, gout, hyperuricemia, pregnancy, lactation, age under 18 years (effectiveness and safety have been established).
To apply caution in patients with renal insufficiency.
Dosage
20 mg / ml
Indications
Comprehensive treatment of suffering a myocardial infarction, coronary heart disease, cardiac arrhythmias associated with the use of cardiac glycosides, amid myocardiodystrophy after the transferred infectious diseases. liver disease (hepatitis, cirrhosis, fatty) urokoproporfirii. Operations in the isolated kidney (as pharmacological tools protection at shutdown of blood circulation).
Interaction with other drugs
Currently, it is not revealed.
pharmachologic effect
Pharmacological group:
Metabolic means.
Pharmacodynamics:
Riboxinum – derivative (nucleoside) purines – precursor of adenosine triphosphate (ATP). It refers to a group of drugs that stimulate metabolic processes. It provides anti-hypoxic and anti-arrhythmic effects. Increases myocardial energy balance, improves coronary circulation, prevents the effects of intraoperative renal ischemia. It is directly involved in the metabolism of glucose metabolism and promotes the activation under hypoxic conditions and in the absence of ATP.
It activates the metabolism of pyruvic acid required to ensure normal process of tissue respiration, and promotes the activation of xanthine dehydrogenase. Stimulates the synthesis of nucleotides, enhances the activity of some enzymes of the Krebs cycle. Penetrating into cells has a positive effect on metabolic processes in myocardium – increases the strength of heart rate and promotes more complete relaxation of the myocardium in diastole, thereby increasing stroke volume. The mechanism of antiarrhythmic action is not completely understood.
Reduces platelet aggregation activates the regeneration of tissues (especially infarction and mucous membrane of the gastrointestinal tract).
Pharmacokinetics:
It is metabolized in the liver to form glucuronic acid and its subsequent oxidation. In the small amount excreted in the urine.
Conditions of supply of pharmacies
On prescription.
side effects
Allergic reactions: itching, flushing of the skin (the drug should be discontinued).
Rarely increased concentration of uric acid in the blood increase gout (with prolonged use).
special instructions
To apply caution in patients with renal insufficiency.
Storage conditions
In a dry, dark place at a temperature of 20-25 ° C. In the reach of children.
Dosing and Administration
The drug used intravenous bolus or slow infusion (40-60 drops in 1 minute).
Treatment is initiated by introducing 200 mg (10 ml of a 2% solution) 1 time per day, then if tolerated, the dose was increased to 400 mg (20 ml of a 2% solution) 1-2 times a day. The duration of treatment is 10-15 days.
Bolus of the drug may in acute heart rhythm disturbances in a single dose of 200-400 mg (10-20 ml of 2% solution).
For pharmacological renal protection subjected to ischemia Riboxinum administered intravenously in a single dose of 1200 mg (60 ml of a 2% solution) for 5-15 minutes prior to clamping of the renal artery, then another 800 mg (40 ml of a 2% solution) immediately after restoration of blood circulation .
When drip into the vein 2% solution of the preparation is diluted in 5% dextrose (glucose) or isotonic sodium chloride solution (250 mL).
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

Russia

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