Polyoxidonium suppositories vagin.-Recto. 6mg 10 pc

Description

Composition
Active substance:
Azoximer bromide – 6 mg
Excipients:
mannitol – 1.8 mg Povidone K 17 – 1.2 mg cocoa butter – 1291.0 mg
Description:
Suppositories are torpedo-shaped, light yellow color with a weak specific smell of cocoa butter.
Suppositories should be uniform. On the cut tolerance of air core or funnel-shaped depressions.
Product form:
Rectal and vaginal suppositories, 6 mg.
5 suppositories in blisters made of PVC film. Two outline package together with instructions for use placed in a pile of cardboard.
Contraindications
– Increased individual sensitivity;
– pregnancy, breast-feeding;
– Children up to age 6 years;
– acute renal failure
Carefully
If you have a disease, referred to in this section, contact your doctor before taking the drug:
chronic renal failure (appoint not more than 2 times per week).
Dosage
6 mg
Indications
It is used in adults and children over 6 years for the treatment and prevention of infectious and inflammatory diseases (viral, bacterial and fungal etiology), in the stage of exacerbation and remission.
For treatment (combination therapy):
– acute and recurrent infectious exacerbations of chronic inflammatory diseases of different localization, bacterial, viral and fungal etiology;
– inflammatory diseases of the urogenital tract (urethritis, cystitis, pyelonephritis, prostatitis, salpingoophoritis, endomyometritis, vaginitis, cervicitis, tservikoza, bacterial vaginosis);
– various forms of tuberculosis;
– allergies (including hay fever, bronchial asthma, atopic dermatitis), complicated by recurrent bacterial, fungal and viral infection;
– rheumatoid arthritis, complicated by recurrent bacterial, fungal and viral infections, against long-term use of immunosuppressants;
– to activate the regenerative processes (fractures, burns, trophic ulcers);
– in the treatment of cancer during chemotherapy and radiation therapy to reduce nephrotoxicity – and hepatotoxic drugs.
For the prevention (monotherapy):
– recurrent herpes infections of the urogenital tract;
– exacerbations of chronic infection foci;
– influenza and other acute respiratory infections in pre-epidemic and the epidemic season in immunocompromised individuals;
– secondary immunodeficiencies resulting from aging or exposure to adverse factors.
Interaction with other drugs
Azoximer bromide does not inhibit isozymes CYP1A2, CYP2C9, CYP2C19, CYP2D6, cytochrome P-450, and the drug is compatible with many drugs, including antibiotics, antiviral, antifungal and antihistamines, glucocorticosteroids and cytostatics.
If you accept the above or any other medicines (including OTC), before taking Polioksidoniya® consult your doctor.
Overdose
Cases of overdose are not logged in
pharmachologic effect
Pharmacological group:
immunomodulatory agent.
Pharmacodynamics:
Azoximer bromide has a complex action: immunomodulatory, detoxicating, antioxidant, anti-inflammatory moderate.
The basis for an immunomodulatory mechanism of action azoximer bromide is a direct effect on the phagocytic cells and natural killer cells, and stimulation of antibody synthesis and interferon-alpha and interferon-gamma.
Detoxification and antioxidant properties azoximer bromide is largely determined by the structure and nature of the high molecular weight of the drug.
Azoximer bromide increases resistance of the organism against both local and generalized infections of bacterial, fungal and viral etiology. Restores immunity in secondary immunodeficiency, caused by different infection, trauma, complications after surgical operations, burns, autoimmune diseases, malignancies, the use of chemotherapeutic agents, cytostatic drugs, steroid hormones.
Azoximer bromide blocked soluble toxic substances and microparticles has the ability to excrete toxins, heavy metal salts, inhibit lipid peroxidation both due to interception of free radicals and by elimination of the catalytically active Fe2 + ions. Azoximer bromide reduces the inflammatory response by normalizing the synthesis of pro- and anti-inflammatory cytokines.
Azoximer bromide well tolerated, has no mitogenic, polyclonal activity, antigenic properties, has no allergenic, mutagenic, embryotoxic, teratogenic and carcinogenic effects.
Pharmacokinetics:
Azoximer bromide in suppositories for rectal administration has a high bioavailability (no less than 70%), reaching a maximum blood concentration at 1 hour after administration. poluraspredeleniya Period – about 0.5 hours, elimination half – 36.2 hours. The organism hydrolyzed to oligomers that are derived mainly kidneys. The cumulative effect is not.
Pregnancy and breast-feeding
Contraindicated for use during pregnancy and breast-feeding period (clinical experience with offline).
In the experimental use of the drug Polioksidoniy® in animals revealed no embryotoxic and teratogenic effects, effects on fetal development.
Before applying Polioksidoniy® medication if you are pregnant or suspect that you might be pregnant, or planning to become pregnant, you must consult your doctor.
During the period of breast-feeding before using Polioksidoniy® drug should consult a doctor.
Conditions of supply of pharmacies
Without recipe.
side effects
Very rarely, local reactions in the form of redness, swelling, itching perianal area, vaginal itching due to individual sensitivity to the drug.
If you notice any side effects not listed in the instructions, tell your doctor
special instructions
With the development of allergic reactions should stop using Polioksidoniy® drug and consult a doctor.
If necessary, termination of therapy with, cancellation can be carried out immediately. In the case of a single dose of the drug should pass to take it as soon as possible, but if it is time for your next dose, dose to the reception not increase.
Do not use the drug if there is visual evidence of his unfitness (stacking fault, change the color of a suppository).
Effect on the ability to drive mechanisms and
Use of the drug Polioksidoniy® does not affect the ability to drive vehicles, machinery maintenance and other activities that require high concentration and psychomotor speed reactions.
Storage conditions
In a dry place at a temperature of from 2 to 15 degrees. Keep out of the reach of children
Dosing and Administration
Use according to the drug only indications that the application and in those doses which are specified in the instruction.
If after treatment there is no improvement or symptoms are aggravated, or there are new symptoms, you should consult with your doctor.
Rectally and vaginally, 1 times a day every day, every other day or 2 times a week.
If necessary, may conduct repeated courses of therapy in 3-4 months. When the re-appointment of the drug efficacy is not reduced.
Recommended Regimen
For the treatment of adults:
– rectally 1 suppository 1 time a day after cleansing the bowel;
– vaginally introduced into the vagina in the supine position during gynecological diseases 1 suppository 1 once daily (at night).
chronic infectious and inflammatory diseases in the acute stage – Suppositories 12 mg 1 time per day every day for 3 days, then every other day. The course of treatment – 10 suppositories;
acute infectious processes and for activating regenerative processes (fractures, burns, trophic ulcers) – 1 suppositories 12mg once daily. The course of treatment – 10 suppositories;
gynecological diseases – Suppositories 12 mg 1 time per day every day for 3 days, then every other day. The course of treatment 10 suppository;
during exacerbations urological diseases (urethritis, pyelonephritis, cystitis, prostatitis) – 1 suppositories 12mg once daily. The course of treatment – 10 suppositories;
in pulmonary tuberculosis form – Suppositories 12 mg 1 time per day every day for 3 days, then every other day. The course of treatment 20 suppository. It is further possible to use a maintenance therapy suppositories 6 mg 2 times a week course of 2-3 months;
in the treatment of cancer during chemotherapy and radiotherapy – suppositories, 12 mg daily for 2-3 days prior to the course of chemotherapy or radiotherapy. Next, 12 mg 2 times a week to 20 rate suppositories;
allergic diseases complicated with infectious syndrome – Suppositories 12 mg of 1 times a day every day. The course of treatment – 10 suppositories;
rheumatoid arthritis – Suppositories 12 mg every other day. The course of treatment – 10 suppositories
For the prevention (monotherapy):
foci exacerbations of chronic infections, recurrent herpes infections of the urogenital tract – Suppositories 12 mg every other day. Course – 10 suppositories;
Influenza and SARS – suppositories, 12 mg 1 time per day. Course – 10 suppositories;
secondary immunodeficiencies resulting from aging suppositories of 12 mg 2 times a week. Course – 10 suppository 2-3 times a year.
For the treatment of children and adolescents 6 to 18 years:
Children and adolescents from 6 to 18 years suppositories are administered only rectally, 1 suppository 1 to 6 mg once daily after cleansing the bowel.
chronic infectious and inflammatory diseases in the acute stage – 6 suppositories 1 mg once a day every day for 3 days, then every other day. The course of treatment – 10 suppositories;
acute infectious processes and for activating regenerative processes (fractures, burns, trophic ulcers) – 6 suppositories 1 mg once daily. The course of treatment – 10 suppositories;
during exacerbations urological diseases (urethritis, pyelonephritis, cystitis, prostatitis) – 6 suppositories 1 mg once daily. The course of treatment – 10 suppositories;
in pulmonary tuberculosis form – suppositories 6 1 mg once daily for 3 days, then every other day. The course of treatment 20 suppository. It is further possible to use a maintenance therapy suppositories 6 mg 2 times a week course of 2-3 months;
in the treatment of cancer during chemotherapy and radiotherapy – suppositories 6 mg daily for 2-3 days prior to the course of chemotherapy or radiotherapy. Next, 6 mg 2 times a week to 20 rate suppositories;
allergic diseases complicated with infectious syndrome suppositories 6 1 mg once daily. The course of treatment – 10 suppositories;
rheumatoid arthritis – suppositories 6 mg a day. The course of treatment – 10 suppositories.
For the prevention (monotherapy):
foci exacerbations of chronic infections, recurrent herpes infections of the urogenital tract – suppositories 6 mg a day. Course – 10 suppositories influenza and SARS – 1 mg suppositories 6 times a day, suppositories course 10;
For patients receiving long-term immunosuppressive therapy, cancer exposed to radiation having acquired defects of the immune system – HIV is a long-term of 2-3 months to 1 year Polioksidoniem® supportive therapy (adults and 12 mg for children older than 6 years – 6 mg 1 -Two times per week).
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist