Pirroksan tab 15mg 50 pc


Pirroksan tab 15mg 50 pc

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Active substance:
proroksana hydrochloride – 15 mg
ludipress® [lactose monohydrate – 78.3 mg Povidone K-30 – 2.95 mg Crospovidone – 2.95 mg] – 84, 2 mg; Magnesium stearate – 0.8 mg.
Round biconvex white or nearly white.
Product form:
Tablets 15mg.
10 tablets in blisters. 5 the contour of cellular packaging together with instructions for use in a pile of cardboard.
– hypersensitivity to the active substance or auxiliary components of the drug;
– expressed atherosclerosis;
– expressed cerebrovascular disease (including stroke, transient ischemic attack history);
– Coronary heart disease (II-IV functional class)
– circulatory insufficiency II-III level;
– hypotension;
– cardiogenic shock;
– bradycardia;
– myocardial infarction;
– galactose intolerance, glucose-galactose malabsorption, lactase deficiency;
– Children up to age 18 years.
Caution should be used in elderly patients with ischemic heart disease, arrhythmias, peptic ulcer.
It is recommended to control blood glucose concentration (perhaps improving endogenous insulin).
15 mg
– somatoform autonomic dysfunction, which flows through Sympathoadrenal type, including with an increase in blood pressure (as a symptomatic agent in the complex therapy);
– allergic dermatitis (as a symptomatic agent in the complex therapy for relief of itching).
Interaction with other drugs
– amplifies neuroleptic action (phenothiazine derivatives, butyrophenone, difenilbutilpiperidina, thioxanthenes);
– against the background of the use of procainamide may decrease stroke volume of the heart;
– while the use of epinephrine may perversion of its action – the development of the depressive effect instead pressor;
– simultaneous application proroksana with antihypertensives leads to potentiation of their mutual effects on blood pressure.
In that case, if you are taking other medicines, before taking this medication, you should consult with your doctor.
On the part of the gastrointestinal tract: diarrhea, increased secretion of hydrochloric acid in the stomach.
If any of these instructions side effects are compounded, or if you notice any other side effects not mentioned in the instructions, tell your doctor.
pharmachologic effect
Pharmacological group:
Proroksan has hypotensive and antipruritic effect. Blocks postsynaptic alpha1-and presynaptic alpha2-adrenergic receptors, regardless of their localization. It has peripheral and central influence. Reduces sensitivity to adrenaline adrenergic receptors, altering the permeability of cell membranes. Reduces the intensity of the stimulation of the hypothalamic structures, reducing the release of tropic hormones, hormones of peripheral glands. Adrenergic vasoconstrictive attenuates transmission pulses eliminates spasm and expands peripheral vessels, particularly arterioles and precapillaries. It improves blood flow to muscles, skin, mucous membranes. Inhibits excitability diencephalic brain structures and adjusts tone simpatoadrenalovoj system.
It is found that the drug is well absorbed in the gastrointestinal tract, but the effective concentration is attained only after 30 – 40 minutes and lasts 3-4 hours. Plasma protein binding is weak. In preparation marked by a large volume of distribution, it penetrates quickly into various tissues and body fluids, including cerebrospinal fluid. It penetrates through the blood-tissue barriers, including the blood-brain. Selectively delayed in the hypothalamus, the rear region which contains predominantly noradrenergic neurons. Excreted mainly by the kidneys. About 70% of the administered dose excreted by the kidneys within 24 hours.
In animal studies, when administered intraperitoneally half-life has not been established, wherein in plasma 1 hour after administration remained less than 5% of the administered dose, and after 2 hours – only traces. In the brain through 1 hour showed 22%, after 2 hours – 6% of the maximum concentration. Also proroksanom experiments it was shown with the labeled carbon, the products of its metabolism are capable of long time (up to 10 days) to linger in various organs and tissues (plasma, brain, liver, kidneys).
Pregnancy and breast-feeding
Contraindicated for use during pregnancy and breastfeeding.
Conditions of supply of pharmacies
On prescription.
side effects
With the cardiovascular system: bradycardia, hypotension, occurrence of angina attacks in predisposed patients, orthostatic hypotension, arrhythmia, dizziness, flushing of the skin, nasal congestion.
On the part of the gastrointestinal tract: diarrhea, increased secretion of hydrochloric acid in the stomach.
If any of these instructions side effects are compounded, or if you notice any other side effects not mentioned in the instructions, tell your doctor.
special instructions
Features of action of the drug at the first reception
When receiving the first dose of drug may sharp decrease in blood pressure, fainting, headache, weakness, palpitations, and degradation in the subjective state ( “first dose phenomenon”) that is not a cause for discontinuation of the drug, since the effect disappears at readmission. Also note drowsiness, fast passing numbness language. Furthermore, it is advisable to monitor the concentration of glucose in the blood due to a possible increase endogenous insulin levels. In this connection, it is necessary to begin treatment under the supervision of a physician with a minimum effective dose and bed rest after drug administration for 6-8 hours.
Effect of the drug on the ability to drive, the mechanisms
In the period of treatment is not recommended to drive and engage in potentially hazardous activities that require high concentration and psychomotor speed reactions.
Storage conditions
In a dry, dark place at a temperature not higher than 25 ° C.
Keep out of the reach of children.
Dosing and Administration
When somatoform autonomic dysfunction flowing through sympathoadrenal type in combined therapy administered 15-30 mg (1-2 tablets) orally 2-3 times per day. Duration of treatment is determined by the attending physician.
In allergic dermatitis in the complex therapy recommended to appoint 15-30 mg (1-2 tablets) inwardly before bedtime. Duration of treatment is determined by the attending physician.
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg


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