Phosphogliv forte caps. 300mg + 65mg 50 pc

$23.05

Phosphogliv forte caps. 300mg + 65mg 50 pc

Quantity:

Description

Composition
Active substance:
1 capsule contains: phospholipid (lipoid PPL-400) – 400.0 mg [in terms of 100% substance (main component – phosphatidylcholine 73-79%)] – 300.0 mg sodium glycyrrhizinate (trisodium salt of glycyrrhizic acid) – 65 0 mg.
Excipients:
Butylhydroxytoluene – 0.1 mg ethyl alcohol variety “superior” or “extra” (ethanol) – 12 mg, sunflower oil or corn oil – 22.9 mg
Capsule shell
Hard gelatin capsules № 0
The housing and cover: titanium dioxide, red iron oxide colorant, dye iron oxide black, iron oxide yellow colorant, gelatine.
Description:
hard gelatine capsules № 0; body and capsule cap – brown.
The contents of the capsule – butyric pasty mass from light yellow to orange-brown color with a faint characteristic odor.
Product form:
Capsules.
30, 50, 100, 200 or 300 capsules in plastic containers and lids of a high density polyethylene or propylene polymer or cans, sealed with a tamper evident caps with desiccant insert.
10 capsules in blisters of PVC film and aluminum foil. 1 or container 2, 3, 5 contour cell packages together with instructions for use placed in a pile of cardboard.
Contraindications
Antiphospholipid syndrome; use in patients with known intolerance corn or corn products (the drug in the composition may contain excipients corn oil); hypersensitivity to the drug; pregnancy, breast-feeding; Children up to age 12 years.
Carefully
Portal hypertension, arterial hypertension.
Dosage
300 mg + 65 mg
Indications
Fatty liver (steatosis), alcohol, toxic, including drugs, liver damage.
In the combined therapy of viral hepatitis, liver cirrhosis, psoriasis.
Interaction with other drugs
Glycyrrhizic acid is a synergist of corticosteroid hormones, enhances and prolongs their action.
Overdose
Overdose symptoms: sodium retention and fluids in the body, manifested by peripheral edema and increase in blood pressure; hyponatremia.
Treatment: depending on the severity of the symptoms of an overdose, it is necessary to reduce the dose of the drug and / or assign spironolactone 50-100 mg per day.
pharmachologic effect
Pharmacological group:
Hepatoprotective agent.
Pharmacological properties:
Combined tool. Has a membrane stabilizing, hepatoprotective and antiviral effect.
Phosphatidylcholine (main component phospholipids) is a major structural element of cellular membranes and intracellular, capable of restoring the structure and function in case of damage, providing cytoprotective effect.
Normalizes protein and lipid metabolism, prevents loss of hepatocytes, enzymes and other active substances, restores detoxifying liver function, inhibits the formation of connective tissue, reducing the risk of fibrosis and cirrhosis.
Glitsirat (glycyrrhizinic acid and salts thereof) possesses anti-inflammatory action, inhibits viral replication in the liver and other organs by stimulating production of interferons, increase of phagocytosis, increase the activity of natural killer cells. It has a hepatoprotective effect due to the antioxidant and membrane stabilizing activity. Potentiates the effects of endogenous glucocorticoids, providing anti-inflammatory and antiallergic effects in liver lesions of non-infectious.
When skin lesions due to membrane stabilizing and antiinflammatory action component limits the spread process and contributes to the regression of the disease.
Pharmacokinetics:
Phosphatidylcholine. Over 90% of ingested phospholipids are absorbed in the small intestine. Most of them are cleaved by phospholipase A to 1-acetyl lysophosphatidylcholine, 50% of which is inversely acetylation in polyunsaturated phosphatidylcholine in the process of absorption in the intestinal mucosa. Polyunsaturated phosphatidylcholine with shock lymph enters the bloodstream, where, mainly associated with high density lipoproteins to the liver form. The pharmacokinetics in humans was studied using radiolabelled dilenoleilfosfatidilholina – 3H (choline part) and 14C (linoleic acid residue). 3H maximum concentration achieved after 6-24 hours, accounting for 19.9% ​​of the administered dose; 14C – after 4-12 hours, amounting 27.9%. The half-life choline component is 66 hours, linoleic acid residue – 32 hours. The feces detected 3H 2% and 4.5% – 14C, in the urine – 6% and the minimum amount of 3H 14C. Both isotopes absorbed in the intestine by more than 90%.
Glycyrrhizic acid. Following oral administration in the gut by the enzyme beta -glucuronidase, produced by bacteria of normal microflora of glycyrrhizic acid is formed active metabolite – beta-glycyrrhetic acid which is absorbed into the systemic circulation. Blood beta glycyrrhetic acid is bound to albumin, and is almost entirely transported to the liver. Isolation of beta-glycyrrhetic acid occurs predominantly in bile, in the residual amount – the urine. According to the experimental data, the phospholipids improve lipophilic properties glycyrrhizic acid, increasing the intensity and speed of its sucking to more than 2 times.
Pregnancy and breast-feeding
The drug is contraindicated during pregnancy and lactation (efficacy and safety data are insufficient).
Conditions of supply of pharmacies
On prescription.
side effects
Allergic reactions: skin rash, difficulty in nasal breathing, conjunctivitis, cough.
Cardio-vascular system: transient (transient) increase in blood pressure, peripheral edema.
On the part of the digestive system: dyspepsia (belching, nausea, abdominal distension), discomfort in the abdomen.
If you experience these symptoms should stop taking the drug and consult a doctor.
special instructions
The product has no effect on the ability to drive vehicles and occupation of other potentially hazardous activities that require high concentration and psychomotor speed reactions.
Storage conditions
Store at a temperature not higher than 25 C.
Keep out of the reach of children.
Dosing and Administration
Inside, during a meal time, with a little water.
Adults take 1-2 capsules 3 times a day for children older than 12 years – 1 capsule 3 times a day. Duration of therapy is determined by the doctor.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

Pharmstandard BRANDS

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