Phosphogliv caps. 65mg + 35mg 50 pc

Description

Composition
Active substance:
1 capsule contains: phospholipid (lipoid C 80) (in terms of 100% substance) (the main component is phosphatidylcholine 73-79%) – 65 mg sodium glycyrrhizinate (trisodium salt of glycyrrhizic acid) – 35 mg ;.
Excipients:
Microcrystalline Cellulose – 141.2 mg Calcium carbonate – 204.7 mg Calcium stearate – 0.9 mg Talc – 7.7 mg colloidal silicon dioxide (Aerosil) – 5.5 mg into hard gelatin capsules – 96.0 mg [housing: sunset yellow dye (E110), 1,0% titanium dioxide (E171), 1,0% gelatin – 100.0%; cap: titanium dioxide (E 171) – 0.2% ferric oxide, black dye (E 172) – 3.5% gelatin – 100.0%].
Description:
Hard gelatin capsules №0, the capsule housing – orange cap – black. Contents of capsules – a granulated powder from white with a slightly yellowish tinge to light yellow color with a weak specific smell.
Product form:
Capsules.
30, 50, 100, 200 or 300 capsules in plastic containers and lids of a high density polyethylene or polypropylene.
10 capsules in blisters of PVC film and aluminum foil. 1 a container or a 2,3,5 contour of cellular packaging together with instructions for use placed in a pile of cardboard.
Contraindications
Hypersensitivity to glycyrrhizic acid, phosphatidylcholine or other components of the formulation.
Antiphospholipid syndrome.
Pregnancy (efficacy and safety data are insufficient).
Breastfeeding (efficacy and safety data are insufficient).
Children age under 12 years of age (efficacy and safety data are insufficient).
Carefully.
In patients with portal hypertension. In patients with hypertension. In the presence of these diseases, before the drug should consult a physician.
Dosage
65 mg + 35 mg
Indications
Fatty degeneration of the liver (steatosis), alcohol, toxic, including drugs, liver damage.
In the combined therapy of viral hepatitis, cirrhosis and psoriasis.
Interaction with other drugs
Not described.
Overdose
Cases of overdose have been reported.
pharmachologic effect
Pharmacological group:
Hepatoprotective agent.
Pharmacological properties:
Combined tool. Has a membrane stabilizing, hepatoprotective and antiviral effect.
Phosphatidylcholine (phospholipid active substance) is a major structural element of cellular membranes and intracellular, capable of restoring the structure and function in case of damage, providing cytoprotective effect. Normalizes protein and lipid metabolism, prevents loss of hepatocytes, enzymes and other active substances, restores the detoxifying liver function, inhibits the formation of connective tissue, reducing the risk of fibrosis and cirrhosis.
Glitsirat (glycyrrhizinic acid and salts thereof) possesses anti-inflammatory action, inhibits viral replication in the liver and other organs by stimulating production of interferons, increase of phagocytosis, increase the activity of natural killer cells. It has a hepatoprotective effect due to the antioxidant and membrane stabilizing activity. Potentiates the effects of endogenous glucocorticoids, providing anti-inflammatory and antiallergic effects in liver lesions of non-infectious.
When skin lesions due to membrane stabilizing and antiinflammatory action component limits the spread process and contributes to the regression of the disease.
Pharmacokinetics:
phosphatidylcholine
Over 90% of ingested phospholipids absorbed in the small intestine. Most of them are cleaved by phospholipase A to 1-acetyl lysophosphatidylcholine, 50% of which is inversely acetylation in polyunsaturated phosphatidylcholine in the process of absorption in the intestinal mucosa. Polyunsaturated phosphatidylcholine drain lymph enters the bloodstream, where, mainly associated with high density lipoproteins to the liver form. The pharmacokinetics in humans was studied using radiolabelled dilenoleilfosfatidilholina – 3H (choline part) and 14C (linoleic acid residue). 3H maximum concentration achieved after 6-24 hours, accounting for 19.9% ​​of the administered dose; 14C – after 4-12 hours, amounting 27.9%. The half-life choline component is 66 hours, linoleic acid residue – 32 hours. The feces detected 3H 2% and 4.5% – 14C; in urine – 6% and the minimum amount of 3H 14C. Both isotopes absorbed in the intestine by more than 90%.
Gpitsirrizinovaya acid
After oral administration, the intestine under the influence of the enzyme (beta-glucuronidase produced by bacteria of normal microflora of glycyrrhizic acid is formed active metabolite -. (Beta -glitsirretovaya acid which is absorbed into the systemic circulation in blood beta -glitsirretovaya acid binds to albumin and almost completely transported to the liver Isolation beta -glitsirretovoy acid occurs predominantly in bile, in the residual quantity -. excretion.
According to the experimental data, the phospholipids improve lipophilic properties glycyrrhizic acid, increasing the intensity and speed of its sucking to more than 2 times.
Conditions of supply of pharmacies
Without recipe.
side effects
Typically Phosphogliv drug is well tolerated, side effects develop very rarely, according to post-marketing surveillance – Frequency
Allergic reactions: skin rash, difficulty in nasal breathing, conjunctivitis, cough.
Cardio-vascular system: transient (transient) increase in blood pressure, peripheral edema.
On the part of the digestive system: dyspepsia (belching, nausea, bloating), abdominal discomfort.
If you experience these symptoms should stop taking the drug and consult a doctor.
special instructions
In the case of high blood pressure you should stop taking the drug and consult a doctor.
Effects on ability to drive and use machines.
The drug has no negative impact on the ability to drive and perform other tasks that require high concentration and speed of psychomotor reactions.
Storage conditions
Store at a temperature not higher than 25 C.
Keep out of the reach of children.
Dosing and Administration
Inside, during a meal time, not liquid, squeezed small amounts of liquid.
The recommended dosing regimen in adults and children over 12 years – 2 capsules 3 times a day. Duration of treatment may be up to 6 months, on average – 3 months.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist