Phlebodia tab 600 p / v 600mg film 60 pcs

Description

Composition
Active substance:
1 tablet contains:
Diosmin on dry substance, 600 mg.
Excipients:
Talc-10.24 mg, colloidal silicon dioxide, 3.5 mg of stearic acid, 50.05 mg of microcrystalline cellulose to 910 mg sheath: Sepifilm® 002 (hypromellose (E 464) – 9,832 mg, microcrystalline cellulose -7.866 mg macrogol 8 stearate type 1 – 1,967 mg). Sepispsrs® pink AR 5523 (propylene glycol – traces hypromellose (E 464) – 0.458 mg titanium dioxide (E 171) -4.026 mg carmine dye [Ponceau 4R] (E 124) – 0.401 mg, black iron oxide (E 172) – 0.130 mg iron oxide red (E 172) – 0.020 mg).
Opaglos® 6000 (carnauba wax (E 903) – 0.075 mg, beeswax (E 901) – 0.075 mg, shellac (E 904) – 0.150 mg ethanol 95 ° – trace).
Description:
Round biconvex tablets, film-coated pink.
Product form:
Film-coated tablets.
15 tablets in PVC / aluminum blister.
I, 2 or 4 blisters with instructions for use in a cardboard package.
Contraindications
Hypersensitivity to the drug during breastfeeding, children under 18 years, pregnancy (I term) (application experience limited).
Dosage
600 mg
Indications
In the combined therapy – to relieve symptoms lymphovenous insufficiency of the lower limbs: a feeling of heaviness or fatigue in the legs, pain; – additional treatment in violation of the microcirculation: – symptomatic treatment of acute hemorrhoids.
Interaction with other drugs
No clinically significant effects of interaction with other drugs has not been described.
Overdose
Symptoms of overdose are not described.
pharmachologic effect
Pharmacological group:
Angioprotective means.
Pharmacological properties:
The drug has flebotoniziruyuschim action (reduces extensibility veins increases tone vein (dose-dependent effect), reduces venous stasis), improves lymphatic drainage (increases the tone and frequency of contraction of the lymph capillaries, increases their functional density reduces lymphatic pressure), improves (increases capillary resistance (dose-dependent effect), reduces their permeability), reduces adhesion of leukocytes to the venous wall and their migration into tissues paravenoznye improves the diffusion of oxygen and perfusion in the skin tissue, clothes the anti-inflammatory action. Enhances vasoconstrictor action of adrenaline, noradrenaline, inhibit the production of free radicals, prostaglandins and thromboxane.
Pharmacokinetics:
Rapidly absorbed from the gastrointestinal tract, detected in plasma at 2 hours after administration. Maximum plasma concentration is achieved in 5 hours after ingestion. Evenly distributed and accumulated in all layers of the wall of the vena cava and subcutaneous veins of the lower extremities, to a lesser extent – in the kidney, liver and lung and other tissues. Selective accumulation of diosmin and / or its metabolites in venous vessels reaches a maximum of 9 hour after administration and is maintained for 96 hours. 79% excreted by the kidneys, the intestine – 11%, with zhelchyo – 2.4%.
Pregnancy and breast-feeding
So far in clinical practice have been no reports of any side effects when using the drug in pregnant women. Use during pregnancy in the II and III trimester only be prescribed by a doctor in cases where the expected benefit to the mother outweighs the potential risk to the fetus.
In experimental studies, there was no evidence of teratogenic effects on the fetus. During breastfeeding is not recommended to take the drug because There are no data on the penetration of the drug into breast milk.
Conditions of supply of pharmacies
Without recipe.
side effects
In rare cases, hypersensitivity to the drug, requiring interruption of treatment: on the part of the gastrointestinal tract – dispeiticheskie disorders (heartburn, nausea, abdominal pain), central nervous system – headache.
If any of these instructions side effects are compounded, or if you notice any other side effects not mentioned in the instructions, tell your doctor.
special instructions
acute attack of haemorrhoids treatment is carried out in combination with other drugs, in the absence of rapid clinical effect it is necessary to conduct an additional inspection and adjust the therapy.
Effect on the ability to drive
No Information about the negative impact of the drug on the ability of controlling the vehicles and other mechanisms.
Storage conditions
Store at a temperature not higher than 30 ° C.
Keep out of the reach of children.
Dosing and Administration
Before using the drug should consult a doctor.
The drug is intended for oral administration.
Varicose veins of the lower limbs and chronic lymphovenous insufficiency (edema, pain, cramps) appoint I tablet per day in the morning on an empty stomach. Duration of therapy is usually 2 months. During exacerbation of hemorrhoids drug prescribed 2-3 tablets a day with meals for 7 days. If you missed one or more steps of the preparation, you must continue to use the drug in normal mode and in a normal dose.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist