Perindopril Tab n / a film about 8mg 30 pcs Izvarino Pharma


Perindopril Tab n / a film about 8mg 30 pcs Izvarino Pharma



Active substance:
1 tablet contains: Perindopril erbumine – 2.0 mg or 4.0 mg or 8.0 mg.
Pregelatinized corn starch; microcrystalline cellulose; crospovidone; colloidal silicon dioxide; magnesium stearate. composition shell tablet: Opadry II white (85F18422) (polyvinyl alcohol – 40.000% Titanium Dioxide – 25,000%, macrogol – 3350 – 20,200% talc – 14,800%) or Opadry II Green (85F21738) (polyvinyl alcohol – 40.000% Titanium dioxide – 24.345% macrogol – 3350 – 20,200% talc – 14,800% indigo carmine – 0.540%, aluminum varnish yellow -0.115%).
2 mg Tablets: Tablets round, biconvex shape, film-coated white or nearly white. On cross-section – the core of a white or nearly white.
4 mg Tablets: Tablets round, biconvex shape, film-coated from light green to green. On cross-section – the core of a white or nearly white.
8 mg Tablets: Tablets round, biconvex shape, film-coated from gray-green to green with a tinge of grayish color. On cross-section – the core of a white or nearly white.
Product form:
Tablets 2 mg or 4 mg or 8 mg.
Packaging 30 tablets.
Angioedema in history, pregnancy, lactation, infancy, hypersensitivity to perindopril.
To apply caution in patients with renal failure and severe hypertension.
8 mg
Hypertension, chronic heart failure.
Interaction with other drugs
At simultaneous application with antihypertensive agents, muscle relaxants, agents for anesthesia may increase antihypertensive action.
While the use of loop diuretics, thiazide diuretics may increase the antihypertensive action. Severe hypotension, especially after the first dose of the diuretic, apparently, is due to hypovolemia, which leads to transient increased hypotensive effect of perindopril. Increased risk of renal dysfunction.
In an application with sympathomimetics may reduce the antihypertensive effects of perindopril.
While the use of tricyclic antidepressants, antipsychotic agents (neuroleptics) increases the risk of postural hypotension.
In an application with indomethacin decreased antihypertensive activity of perindopril is apparently influenced by inhibiting prostaglandin synthesis NSAIDS (which is believed to play a role in the development of hypotensive effect of ACE inhibitors).
While the use of insulin, sulfonylurea hypoglycemic agents may develop hypoglycemia by increasing glucose tolerance.
While the use of potassium-sparing diuretics (including spironolactone, triamterene, amiloride), potassium preparations, salt substitutes and food supplements containing potassium may develop hyperkalemia (particularly in patients with impaired renal function), as ACE inhibitors reduce the content of aldosterone, resulting in potassium retention in the body amid restrictions potassium excretion or its additional intake.
While the use of lithium carbonate may decrease lithium excretion.
Symptoms: marked reduction of blood pressure, shock, disorders of water and electrolyte balance (hyperkalemia, hyponatremia), renal failure, hyperventilation, tachycardia, palpitations, bradycardia, dizziness, anxiety, and cough.
Treatment: the marked decrease in blood pressure – to give the patient a horizontal position with legs elevated and arrange to replenish blood volume (CBV), if possible – intravenous catecholamines solution. If severe bradycardia refractory to drug therapy (including atropine) shows the installation of an artificial pacemaker. It is necessary to monitor vital functions and concentration of creatinine and electrolytes in the blood serum. Perindopril may be removed from the systemic circulation by hemodialysis. It is necessary to avoid the use of highly permeable polyacrylonitrile membranes.
pharmachologic effect
Pharmacological group:
ACE inhibitor.
ACE inhibitor. It is the prodrug from which the body is formed an active metabolite perindoprilat. It is believed that the mechanism of the antihypertensive action is associated with a competitive inhibition of ACE activity, which leads to lower conversion rate of angiotensin I to angiotensin II, which is a powerful vasoconstrictor. As a result of reducing the concentration of angiotensin II occurs secondary increase in plasma renin activity by eliminating the negative feedback in the release of renin and aldosterone secretion direct reduction. Due vasodilating action, reduces round (afterload), wedge pressure in the pulmonary capillaries (preload) and pulmonary vascular resistance; increases cardiac output and exercise tolerance.
The hypotensive effect develops within the first hour after ingestion perindopril, reaches a maximum at 4-8 hour and continued for 24 hours.
After oral administration perindopril is rapidly absorbed from the gastrointestinal tract. Cmax is achieved within 1 h. The bioavailability is 65-70%.
During metabolism perindopril biotransformed to the active metabolite – perindoprilat (about 20%) and 5 non-active compounds. Perindoprilat Cmax plasma is between 3 and 5 hours after administration. perindoprilat Binding to plasma proteins is negligible (less than 30%) and depends on the concentration of the active substance. The distribution of free perindoprilat close to 0.2 l / kg.
Not accumulates. Repeated reception does not lead to accumulation, and T1 / 2 corresponds to the period of its activity.
When you receive during meals slows metabolism perindopril.
T1 / 2 of perindopril is 1 h.
Perindoprilat excreted by the kidneys; T1 / 2 of its free fraction is 3-5 hours.
In elderly patients and in patients with renal and heart failure perindoprilat is slowing down.
Pregnancy and breast-feeding
Perindopril is contraindicated during pregnancy and lactation (breastfeeding).
Conditions of supply of pharmacies
On prescription.
side effects
The respiratory system: possible dry cough.
From the digestive system: dyspepsia, dry mouth, taste disturbances.
CNS: headache, sleep disorders and / or mood, dizziness; in some cases – seizures.
From hemopoiesis system: a decrease in hemoglobin (especially at the beginning of treatment); rarely – reduction in the number of erythrocytes and / or platelets.
From the kidney: reversible increase in serum creatinine and uric acid.
Allergic reactions: angioedema, rash, pruritus, erythema.
Other: sexual disorders.
special instructions
Before starting treatment with perindopril for all patients recommended study of kidney function.
During treatment with perindopril should regularly monitor kidney function, liver enzymes in the blood, to carry out analyzes of peripheral blood (especially in patients with diffuse connective tissue diseases, in patients receiving immunosuppressive agents, allopurinol). Patients deficient sodium and fluid before the treatment necessary to conduct correction of water-electrolyte imbalance.
During treatment with perindopril hemodialysis can not be performed with the use of membranes of polyacrylonitrile (increased risk of anaphylactic reactions).
Perindopril caution should be used in conjunction with drugs that can cause an increase in potassium level in blood (indomethacin, cyclosporin). Not recommended simultaneous use of potassium-sparing diuretics and drugs potassium.
Storage conditions
Store at a temperature not higher than 25 C.
Dosing and Administration
Starting dose – 2.1 mg / day 1 reception. Supporting dose – 24 mg / day in congestive heart failure, 4 mg (at least – 8 mg) – arterial hypertension in 1 reception.
In renal dysfunction require correction mode depending on the values ​​QC.
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg

Izvarin INN

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