Paracetamol 500mg tabs 20 pcs renewal

Description

Composition
Active substance:
paracetamol – 0.5 g
Excipients:
potato starch – 0.0280 g of stearic acid – 0.0011 g povidone low molecular weight – magnesium stearate 0.0165 g – 0.0044 g
Product form:
The carton 20 tablets at 500 mg
Contraindications
Hypersensitivity to paracetamol. Children under 8 years old.
Carefully
Renal and liver failure, benign hyperbilirubinemia (including Gilbert’s syndrome), viral hepatitis, alcoholic liver disease, alcoholism, pregnancy, lactation, elderly, lack of glucose-6-phosphate dehydrogenase.
Dosage
500 mg
Indications
Moderately or weakly pronounced pain (headache, toothache, migraine pain, neuralgia, myalgia). Increased body temperature when cold and other infectious and inflammatory diseases.
Interaction with other drugs
Stimulants microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants), ethanol and hepatotoxic drugs increase the production of hydroxylated active metabolites, which makes the possibility of severe intoxication with small overdoses. Prolonged use of barbiturates, reduces the effectiveness of paracetamol.
Overdose
Symptoms: during the first 24 hours after administration – paleness of the skin, nausea, vomiting, anorexia, abdominal pain; impaired glucose metabolism, metabolic acidosis. Symptoms of liver function may occur through 12-48 hours after the overdose. In severe overdose – liver failure with progressive encephalopathy, coma, and death; acute renal failure with tubular necrosis (including the absence of severe liver disease); arrhythmia, pancreatitis. Hepatotoxic effect manifests itself in adults when receiving 10 g or more.
Treatment:. Donators administering to SH-groups and precursors of glutathione synthesis – methionine through 8-9 hours after the overdose and N-acetylcysteine ​​- 12 hours The need for additional therapeutic activities (further administration of methionine, / in administering N-acetyl cysteine) is determined depending on the concentration of paracetamol in the blood, and the time elapsed after administration.
pharmachologic effect
Pharmacological group:
Non-narcotic analgesic agent
Pharmacological properties:
Paracetamol has analgesic and antipyretic action. Paracetamol blocks cyclooxygenase I and II only in the central nervous system, affecting the pain and thermoregulatory centers (in inflamed tissues cellular peroxidase neutralize the effect of paracetamol on cyclooxygenase), which explains the almost complete absence of anti-inflammatory effect. No effect on prostaglandin synthesis in peripheral tissues causes lack of a negative effect on water-salt exchange (sodium and water retention), and gastrointestinal mucosa. The possibility of formation of methemoglobin – is unlikely.
Conditions of supply of pharmacies
Without recipe
side effects
Nausea, vomiting, epigastric pain, allergic reactions (rash, pruritus, urticaria, angioneurotic edema).
Rarely – anemia, leukopenia, thrombocytopenia, agranulocytosis.
Dosing and Administration
Applied inside with a large amount of liquid to 0.5 g-1 g 2-3 times a day at intervals of at least 4 hours. The maximum single dose (body weight 40 kg) for adults and adolescents over 12 years is 1 g daily – 4 years
Patients with impaired renal or hepatic function, with Gilbert’s syndrome and in elderly patients interval between doses of the drug should be at least 8 hours, and the daily dose should be reduced.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist