Panadol Tab to dissolve 500mg 12 pieces

$1.22

Panadol Tab to dissolve 500mg 12 pieces

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Description

Composition
Active substance:
500 mg paracetamol.
Excipients:
sorbitol 50 mg, 10 mg sodium saccharin, sodium hydrogencarbonate 1342 mg Povidone 1 mg sodium lauryl sulfate 0.1 mg, 1 mg of dimethicone, citric acid 925 mg, 134.2 mg of sodium carbonate.
Description:
Flat white tablets with bevelled circumferential edge, with the notch on one side. The surface on both sides of the tablet can be slightly rough.
Product form:
2 tablets a laminated strip (bleached Kraft paper / polyethylene / aluminum foil / polyethylene, or paper coated with a glass / polyethylene / aluminum foil / Surlyn). 6 strips of 2 tablets with instructions for use in a cardboard box.
Contraindications
hypersensitivity; Children under 6 years
Dosage
500 mg
Indications
“Panadol®” is used to relieve headache, migraine, toothache, sore throat, back pain, muscle pain, painful menstruation. “Panadol®” is also used for the symptomatic treatment of febrile syndrome (as an antipyretic); at an elevated temperature of the body against “colds” and flu. The drug is designed to reduce the pain at the time of application, and does not affect the progression of the disease.
Interaction with other drugs
Long-term joint use of paracetamol and NSAIDs increases the risk of “analgesic” nephropathy and renal papillary necrosis, onset of end-stage renal failure. Simultaneous long-term use at high doses of paracetamol and salicylates increase the risk of kidney cancer, or bladder. When taken regularly for a long time the drug enhances the effect of indirect anticoagulants (warfarin and other coumarin), which increases the risk of bleeding. Episodic receiving a single dose of the drug has no significant effect on the action of anticoagulants. Diflunisal increases the plasma concentration of paracetamol at 50%, which increases the risk of hepatotoxicity. Barbiturates, carbamazepine, phenytoin, primidone, ethanol, rifampicin, AZT, flumetsinol, phenylbutazone, drugs Hypericum perforatum, tricyclic antidepressants and other inducers of microsomal oxidation increase the production of hydroxylated active metabolites, causing the possibility of severe liver disease with small overdose of paracetamol (5 g, and more ). Inhibitors of microsomal liver enzymes (cimetidine) reduce the risk of hepatotoxicity. Under the influence of paracetamol during removal of chloramphenicol increases 5 times. Simultaneous treatment with paracetamol and alcoholic beverages increases the risk of liver injury and acute pancreatitis. Metoclopramide and domperidone to increase, and cholestyramine reduces the rate of absorption of paracetamol. The drug may reduce the effectiveness of uricosuric drugs.
Overdose
Symptoms: During the first 24 hours after the overdose – nausea, vomiting, stomach pain, sweating, pale skin, anorexia. After 1-2 days determined signs of liver disease (pain in the liver area, increased activity “liver” enzymes). Perhaps the development of glucose metabolism and metabolic acidosis. In adult patients, liver damage develops after receiving more than 10 g of paracetamol. In the presence of factors influencing the paracetamol liver toxicity (see. The section “Interaction with other medications,” “special instructions”) liver possible after receiving more than 5 grams of paracetamol. In severe cases of overdose as a result of hepatic encephalopathy may develop failure (impaired brain function), bleeding, hypoglycemia, brain edema, including death. May develop acute renal failure, acute tubular necrosis, the characteristic features of which is pain in the lumbar region, haematuria (impurity blood or red blood cells in the urine), proteinuria (high protein content in the urine), with severe liver damage can be absent. Cases of cardiac arrhythmia, pancreatitis. Treatment: If you suspect an overdose, even in the absence of symptoms expressed, you must stop using the product immediately and seek medical help. Within 1 hour after overdose recommended gastric lavage and intake ehnterosorbentov (activated carbon, Polyphepanum). It should determine the level of paracetamol in plasma, but no sooner than 4 hours after the overdose (earlier results are unreliable). Introduction acetylcysteine ​​within 24 hours after the overdose. Maximum protective action is provided during the first 8 hours after the overdose with time antidote efficiency sharply falls. If necessary acetylcysteine ​​is administered intravenously. In the absence of vomiting to the patient admission to the hospital may use methionine. The need for additional therapeutic activities (further introduction of methionine in / introduction acetylcysteine) is determined depending on the blood concentration of paracetamol, as well as on the time elapsed after administration. Treatment of patients with serious hepatic dysfunction at 24 hours after ingestion of paracetamol should be carried out together with specialists or poison control center specialized branch of liver diseases.
pharmachologic effect
Pharmacological group:
N02BE01
Pharmacodynamics:
The drug has analgesic and antipyretic properties. Blocks TSOG1 and TSOG2 mainly in the central nervous system, acting on pain centers and thermoregulation. Anti-inflammatory effect is practically absent. It does not cause irritation of the stomach and intestines. It does not affect the water-salt metabolism, as it does not affect the synthesis of prostaglandins in peripheral tissues.
Pharmacokinetics:
Absorption – high, TSmah reached after 0.5-2 hours; Cmax – 5-20 .mu.g / ml. Communication with plasma proteins -15%. Penetrates through the BBB. Less than 1% of the accepted dose of paracetamol nursing mother enters the breast milk. The therapeutically effective concentration of paracetamol in plasma achieved when administered at a dose of 10-15 mg / kg. It is metabolized in the liver (90-95%): 80% unreactive conjugation with glucuronic acid and sulphates to inactive metabolites; 17% undergoes hydroxylation to form 8 active metabolites, which is conjugated with glutathione to form already inactive metabolites. With a lack of glutathione, these metabolites may block the enzyme systems of hepatocytes and cause their death. The metabolism of the drug is also involved isoenzyme SUR2E1. The half-life (T1 / 2) -. 1-4 hours excreted by the kidneys as metabolites, mainly conjugates, only 3% in an unmodified form. In elderly patients with reduced clearance of the drug and increases the half-life.
Pregnancy and breast-feeding
According to epidemiological studies among pregnant paracetamol does not have adverse effects when used in recommended doses during pregnancy. However, the use during pregnancy is possible only after consultation with your doctor. Paracetamol is excreted in breast milk in small quantities. According to published data the application during breastfeeding is not contraindicated.
Conditions of supply of pharmacies
Without recipe
side effects
The recommended dosage is generally well tolerated drug. The following side effects are revealed spontaneously during post-marketing the drug. Side effects are classified according to organ system and frequency. The frequency of side effects is defined as follows: very often (greater than or equal to 1/10), often (greater than or equal to 1/100 and less than 1/10) infrequently (greater than or equal to 1/1000 and less than 1/100), rare ( greater than or equal to 1/10 000 and less than 1/1000) and very rare (greater than or equal to 1/100 and less than 1/10 000 000). Allergic reactions: very rare – in the form of skin rash, itching, angioedema, Stevens-Johnson syndrome, anaphylaxis; From hemopoiesis system: very rarely – thrombocytopenia, methemoglobinemia, hemolytic anemia; The respiratory system: very rarely – bronchospasm (in patients with hypersensitivity to acetylsalicylic acid and other nonsteroidal anti-inflammatory drugs); On the part of the hepatobiliary system: very rarely – liver dysfunction. With prolonged use at high doses, increases the likelihood of human liver and kidney (renal colic, nonspecific bacteriuria, interstitial nephritis, papillary necrosis), requires monitoring the blood picture. If you experience any of these side effects, stop taking the drug and consult a doctor immediately.
special instructions
Before taking this medication “Panadol®” need to consult with your doctor if you are taking any of the medicines listed in the section “Interaction with other medicinal products.” If you are taking the drug improved condition is not observed, or headache becomes constant, it is necessary to consult a doctor. Glutathione deficiency due to eating disorders, cystic fibrosis, HIV infection, starvation, depletion causes the possibility of severe liver disease with small overdose of paracetamol (5 g, and more). The drug should not be taken concomitantly with other drugs paratsetamolsoderzhaschimi. Patients who observe a salt-free or low-salt diet, the calculation of the daily intake of salt should be taken into account the sodium content in the tablet (427 mg). In the analysis, the determination of uric acid and blood glucose should inform your doctor about taking medication. With caution should be used in fructose intolerance, since the formulation contains sorbitol. AVOID toxic liver damage paracetamol does not should be combined with drinking alcohol, as well as take people prone to chronic alcohol consumption
When the consumption of sodium hydrogen carbonate in high doses may develop disorders of the gastrointestinal tract, including belching, nausea; it is also possible the development of hypernatremia, in this case it is necessary to control fluid and electrolyte balance and apply the appropriate patient management tactics.
Storage conditions
Store at a temperature not higher than 25 ° C. Keep out of reach of children.
Dosing and Administration
Inside. “Panadol®” soluble tablet, to be dissolved before taking not less than 100 ml (half a cup) of water. Adults (including elderly): 1-2 tablets (0.5 – 1 g) up to 4 times a day, as needed. The maximum single dose – 2 tablets (1 g). The maximum daily dose – 8 tablets (4 g). The interval between doses – at least 4 hours. Children dose is calculated based on the weight of the baby’s body: the maximum single dose – 15 mg / kg body weight, with a maximum daily dose – 60 mg / kg body weight. Children (6-9 years): 1/2 tablet (250 mg) to 4 times per day, as needed. The maximum single dose – 1/2 pill (250 mg). The maximum daily – 2 tablets (1 g). The interval between doses – at least 4 hours. Children (9-12 years): 1 tablet (500 mg) to 4 times per day, as needed. The maximum single dose – 1 tablet (500 mg). The maximum daily dose – 4 tablets (2 g). The interval between doses – at least 4 hours. In adults, the drug is not recommended to use more than 5 days as an analgesic, and more than 3 days as antipyretic without prescription and a physician monitoring. In children, the drug is not recommended for more than 3 days without prescription and a physician monitoring. It does not exceed this dose. In case of exceeding the recommended dose, immediately consult a doctor, even if you feel well, because of the risk of delayed serious liver damage. Increasing daily dose or duration of treatment is possible only under medical supervision.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

Panadol

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