Panadol suppositories 125mg 10 pieces

$1.30

Panadol suppositories 125mg 10 pieces

Quantity:

Description

Composition
Active substance:
125 mg paracetamol
Excipients:
hard fat 890 mg.
Description:
White or almost white in appearance homogeneous fatty suppositories conical shape with no physical defects and visible impurities.
Product form:
Rectal suppositories, 125 mg
5 or 10 suppositories in blisters (strip) of polyvinyl chloride and polyethylene. 1 or 2 strips together with instructions for use placed in a cardboard box.
Contraindications
Do not use the medication if your child:
– Hypersensitivity to paracetamol or any other ingredient of the formulation;
– severe dysfunction of the liver or kidney;
– blood diseases;
– a genetic absence of the enzyme glucose 6-phosphate dehydrogenase;
– recent inflammation or bleeding in the rectum (contraindication
associated path-administration).
Carefully
Used with caution in impaired liver or kidney function, with Gilbert’s syndrome. In the presence of any of the diseases listed before taking the drug should consult a doctor.
Dosage
125 mg
Indications
Used in children from 6 months up to 2.5 years old (weighing 8 to 12.5 kg) as:
– antipyretic for reducing elevated body temperature during “cold” diseases, influenza, and infectious diseases of childhood (varicella, rubella, pertussis, measles, scarlet fever, epidemic parotitis (Mumps), etc.);
– analgesic for pain associated with teething, toothache, earache with otitis and sore throat. “Children’s Panadol” is recommended to reduce elevated body temperature in children after vaccination.
Interaction with other drugs
If a child is already taking other medications, prior to taking the drug “Children’s Panadol” should consult a doctor.
Barbiturates, carbamazepine, phenytoin, phenytoin, primidone and other anticonvulsants, ethanol, rifampicin, AZT, flumetsinol, phenylbutazone, phenylbutazone, preparations of Hypericum perforatum and other inducers of microsomal oxidation increase the production of hydroxylated active metabolites, causing the possibility of severe liver disease with small overdose of paracetamol (5 g or more).
Inhibitors of microsomal liver enzymes decrease the risk of hepatotoxicity.
Under the influence of paracetamol during removal of chloramphenicol (chloramphenicol)
increases 5 times, thereby increasing the risk of poisoning chloramphenicol (chloramphenicol).
When taken regularly for a long time the drug enhances the effect of indirect anticoagulants (warfarin and other coumarin), which increases the risk of bleeding. Episodic receiving a single dose of the drug has no significant effect on the action of anticoagulants.
Metoclopramide and domperidone to increase, and cholestyramine reduces the rate of absorption of paracetamol. The drug may reduce the effectiveness of uricosuric drugs.
Overdose
Symptoms: During the first 24 hours after the overdose – nausea, vomiting, stomach pain, sweating, pale skin, anorexia. After 1-2 days determined signs of liver disease (pain in the liver area, increased activity “liver” enzymes). Perhaps the development of glucose metabolism and metabolic acidosis. In adult patients, liver damage develops after receiving more than 10 g of paracetamol in children – when taking more than 125 mg / kg body weight. In the presence of factors influencing the paracetamol liver toxicity (see. See “The interaction with other drugs,” “special instructions”) liver possible after receiving more than 5 grams of paracetamol.
In severe cases of overdose as a result of hepatic encephalopathy may develop failure (impaired brain function), bleeding, hypoglycemia, brain edema, including death. May develop acute renal failure, acute tubular necrosis, the characteristic features of which is pain in the lumbar region, haematuria (impurity blood or red blood cells in the urine), proteinuria (high protein content in the urine), with severe liver damage can be absent. Cases of cardiac arrhythmia, pancreatitis.
Prolonged use in excess of the recommended dose may be observed hepatotoxicity and nephrotoxicity (renal colic, nonspecific bacteriuria, interstitial nephritis, papillary necrosis).
Treatment: If you suspect an overdose, even in the absence of symptoms expressed, you must stop using the product immediately and seek medical help. In case of overdose, caused by the introduction of paracetamol rectal, gastric lavage, and receive enterosorbents ineffective. It should determine the level of paracetamol in plasma, but no sooner than 4 hours after the overdose (earlier results are unreliable). Introduction acetylcysteine ​​within 24 hours after the overdose. Maximum protective action is provided during the first 8 hours after the overdose with time antidote efficiency sharply falls. If necessary acetylcysteine ​​is administered intravenously. In the absence of vomiting to the patient admission to the hospital may use methionine. The need for additional therapeutic activities (further introduction of methionine in / introduction acetylcysteine) is determined depending on the blood concentration of paracetamol, as well as on the time elapsed after administration. Treatment of patients with serious hepatic dysfunction at 24 hours after ingestion of paracetamol should be carried out together with specialists or poison control center specialized branch of liver diseases.
pharmachologic effect
Pharmacological group:
non-narcotic analgesic agent.
Pharmacodynamics:
The drug has analgesic and antipyretic properties. Blocking the cyclooxygenase in the central nervous system, acting on pain centers and thermoregulation. Anti-inflammatory effect is practically absent.
It has no effect on the state of the mucous membrane of the gastrointestinal tract and water-salt metabolism, as it does not affect the synthesis of prostaglandins in peripheral tissues.
Pharmacokinetics:
Suction
Absorption high. When rectal administration is rapidly and almost completely absorbed. Maximum plasma concentration of the drug is achieved 2-3 hours after administration.
Distribution
Distribution of paracetamol in the body fluids and tissues are relatively evenly. Plasma protein binding is approximately 15%.
Metabolism
It is metabolized primarily in the liver to form several metabolites. In infants and children younger than 12 years, the main metabolite of paracetamol is conjugated sulphate paracetamol. Children 12 years and older is a major metabolite of paracetamol glucuronide conjugated.
Part of the drug (about 17%) is subjected to hydroxylation with formation of active metabolites which are conjugated with glutathione. With a lack of glutathione, these metabolites of paracetamol may block the enzyme systems of hepatocytes and cause their death.
breeding
The half-life from plasma is 4-5 hours. The main quantity of the drug released after conjugation in the liver. Mainly excreted by the kidneys. Within 24 hours of urine released 90% of the dose of paracetamol. In unaltered output of about 3% of the administered dose of paracetamol.
Conditions of supply of pharmacies
Without a prescription
side effects
The recommended dosage is generally well tolerated drug. The following side effects are revealed spontaneously during post-marketing the drug.
Side effects are classified according to organ system and frequency. The frequency of side effects is defined as follows: very often (greater than or equal to 1/10), often (greater than or equal to 1/100 and less than 1/10) infrequently (greater than or equal to 1/1000 and less than 1/100), rare ( greater than or equal to 1/10 000 and less than 1/1000) and very rare (greater than or equal to 1/100 and less than 1/10 000 000).
Allergic reactions:
Very rarely – a skin rash, pruritus, urticaria, angioedema, Stevens-Johnson syndrome, anaphylaxis;
From hemopoiesis system:
Very rarely – thrombocytopenia, anemia, leucopenia;
The respiratory system:
Very rarely – bronchospasm (in patients with hypersensitivity to aspirin and other nonsteroidal anti-inflammatory drugs);
On the part of the hepatobiliary system:
Very rarely – liver dysfunction.
There may be nausea, vomiting.
If you experience any of these side effects, stop taking the drug and consult a doctor immediately.
special instructions
“Children’s Panadol” rectal show children hardly take pills or prone to vomiting reaction.
In the analysis, the determination of uric acid and blood sugar levels, tell your doctor about the use of the drug “Children’s Panadol”.
When receiving the drug for more than 7 days is recommended to control the peripheral blood and functional state of the liver.
Glutathione deficiency due to eating disorders, cystic fibrosis, HIV infection, starvation, depletion causes the possibility of severe liver disease with small overdose of paracetamol (5 g, and more).
The drug should not be used concomitantly with other drugs paratsetamolsoderzhaschimi.
Storage conditions
Store at a temperature not higher than 25 ° C.
Keep out of the reach of children.
Dosing and Administration
The drug is used rectally. Wash hands and release suppository of a plastic shell. Gently enter suppository index finger into the anus of the child (preferably after enema or spontaneous bowel movements). It will be easier to enter at the position of the child on the left side with one leg pulled up to his stomach.
The average single dose “Child Panadol” depends on the body weight of the child and is 10-15 mg / kg body weight, 3-4 times a day every 4-6 hours.
The maximum daily dose should not exceed 60 mg / kg body weight.
Children weighing 8 to 12.5 kg (usually 6 months to 2.5 years old) are administered 1 suppository (125 mg) 3-4 times a day in 4-6 hours. Do not apply more than 4 candles in the night.
Duration of treatment without consulting a doctor – 3 days.
Do not exceed the recommended dose!
If you accidentally exceeding the recommended dose should immediately consult a doctor, even if the child feels good, because there is a risk of liver injury (see. “Overdose”).
If you are taking the drug the child’s condition does not improve, contact your doctor.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

GlaxoSmithKline Helsker

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