Otrivin spray Nazal. scrapper. children 0.05% fl.p 10ml / e with dozir.ustr PTO 1 pc

Description

Composition
Active substance:
1 ml contains: Xylometazoline hydrochloride 0.5 mg.
Excipients:
sodium dihydrogen phosphate dihydrate – 5 mg, disodium hydrogenphosphate dodecahydrate – 1.7 mg Disodium edetate – 0.5 mg benzalkonium chloride, 50% solution – 0.1 mg (in terms of benzalkonium chloride – 0.05 mg), sorbitol 70% – 20 mg hypromellose 4 th. – 5 mg of sodium chloride – 4 mg, water – up to 1 ml.
Description:
Nasal spray metered (for children) 0.05% as a clear, colorless solution, practically odorless.
Product form:
10 ml – vials of high density polyethylene (1) with a pump action dispenser tip and a protective cap made of polyethylene – packs cardboard.
Contraindications
– hypersensitivity to Xylometazoline and other ingredients; – arterial hypertension; – tachycardia; – expressed atherosclerosis; – glaucoma; – sicca and atrophic rhinitis; – hyperthyroidism; – state after transsphenoidal hypophysectomy; – surgical intervention on meninges (in history); – Children under 2 years old.
Dosage
0.5 mg / ml
Indications
acute respiratory illness with symptoms of rhinitis; – acute allergic rhinitis; – hay fever; – sinusitis; – evstahiit; – Otitis media (to minimize swelling of the mucosa of the nasopharynx); – preparation of the patient for diagnostic procedures in the nasal passages.
Interaction with other drugs
Xylometazoline is contraindicated in patients receiving MAO inhibitors in a given time or receive them during the previous 2 weeks. The simultaneous use of tri- or tetracyclic antidepressants and sympathomimetic drugs can lead to increased sympathomimetic effect of xylometazoline, however such combinations should be avoided.
Overdose
Symptoms: xylometazoline in a topical application of excessive dose or in case of accidental ingestion can cause severe dizziness, increased sweating, a sharp decrease in body temperature, headache, bradycardia, increased blood pressure, respiratory depression, coma and convulsions. Following the increase in blood pressure can be observed its sharp decline. Treatment: appropriate supportive measures should be taken in any suspected overdose, in some cases shown immediate symptomatic treatment under the supervision of a physician. These should include monitoring the patient for several hours. In case of severe poisoning with cardiac arrest resuscitation should be continued for at least 1 hour.
pharmachologic effect
Pharmacological group:
R01AA07
Pharmacodynamics:
Vasoconstrictor drugs for topical use in ENT Practice (decongestant). Xylometazoline has alpha adrenomimeticheskoe action. It causes vasoconstriction of nasal mucosa, eliminating mucosal swelling and nasal congestion. Relieves nasal breathing in rhinitis. Otrivin® well tolerated by patients with sensitive mucosa, its effect does not interfere with the separation of mucus. The preparation has a balanced pH of typical nasal cavity. The preparation includes inactive ingredients – sorbitol and hypromellose which are humectants that can reduce the symptoms of dryness and irritation of the nasal mucosa resulting from the prolonged use of Xylometazoline. In therapeutic drug concentrations does not irritate the mucous membrane, does not cause flushing. Effect occurs within 2 minutes after application and lasts for 12 hours. The in vitro studies have shown that human xylometazoline inhibits rhinovirus infectivity activity causing “cold”.
Pharmacokinetics:
The local application at the recommended doses practically not absorbed, the plasma concentrations below the detection limit.
Pregnancy and breast-feeding
The drug should not be used during pregnancy. During lactation Use only under the supervision of a doctor and after careful assessment of risks and benefits to mother and fetus. It is not allowed to exceed the recommended dose.
Conditions of supply of pharmacies
Without recipe
side effects
Determining the incidence of adverse reactions often> 10); common (> 1/100,
special instructions
Not recommended for use in continuous operation for more than 10 days. Do not exceed the recommended dose, especially in children and elderly patients. Long term (over 10 days) or excessive use may cause the effect of “rebound” (rhinitis medicamentosa) and / or atrophy of nasal mucosa. Effects on ability to drive vehicles and management mechanisms Xylometazoline does not affect the ability to drive vehicles and management mechanisms.
Storage conditions
The drug should be kept out of reach of children at a temperature not higher than 30 ° C.
Dosing and Administration
Children from 2 to 5 years: 1 injection into each nasal passage 1-3 times / day. Children from 6 to 11 years old: 1-2 injections in each nostril 2-3 times / day. Do not apply more than 3 times / day. It is recommended to apply the last time just before bedtime. The drug should be used under adult supervision.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist