Okumed drops Ch. 0.5% 10ml vial

Description

Composition
Active substance:
1 ml of solution contains: timolol maleate, equivalent to 2.5 mg of timolol or timolol maleate,
Timolol is equivalent to 5 mg.
Excipients:
Benzalkonium chloride 0.1 mg 7.0 mg sodium hydrogen phosphate, sodium dihydrogen phosphate 4.0 mg Water for injection to 1 ml.
Description:
The clear, colorless solution.
Product form:
Eye drops of 0.25% and 0.5%.
5 and 10 ml-plastic bottle screw cap with dropper. Each vial-IV together with instructions for use placed in a cardboard box.
5 ml in dark glass bottles, closed with a rubber stopper, a crimped aluminum cap with plastic safety cap. In one glass vial with a sterile dropper, packed in a plastic bag and placed in a cardboard box, together with instructions for use.
Contraindications
Increased individual sensitivity to the drug, as well as patients with a history of present illness following:
Bronchial asthma, or other severe chronic obstructive airway disease;
Sinus bradycardia;
Atrioventricular block II or III degree;
Acute heart failure;
Severe congestive heart failure (III – IV functional class);
Cardiogenic shock;
Allergic reactions with generalized skin rash;
Atrophic rhinitis;
Degenerative corneal diseases;
the neonatal period.
Carefully.
Patients with pulmonary disease, emphysema, severe cerebrovascular insufficiency, congestive heart failure (I-II functional class), sinoatrial blockade, hypotension, diabetes, hypoglycemia, hyperthyroidism, myasthenia, Raynaud’s syndrome, pheochromocytoma, and with concomitant administration of other beta adrenoblokatorov, children’s age.
Dosage
0.5%
Indications
Elevated intraocular pressure (ocular hypertension);
Open-angle glaucoma;
Secondary glaucoma;
As an additional means for reducing the intraocular pressure in angle-closure glaucoma (in combination with miotikami);
Congenital glaucoma (with other therapeutic measures failure).
Interaction with other drugs
Co-administration of the drug Okumed® with eye drops containing epinephrine may cause pupil dilation.
The specific effect of the drug – reduction of intraocular pressure is enhanced by the simultaneous use of eye drops containing pilocarpine and epinephrine; instilled into the eyes of two beta-blockers should not be.
lowering blood pressure and slowing heart rate may increase in the combined use of the drug with blockers of slow calcium channels, reserpine and other beta-blockers.
Concomitant use with insulin or oral antidiabetic agents may lead to hypoglycemia.
It is impossible to simultaneously apply with antipsychotic drugs (neuroleptics) and antianxiety drugs (anxiolytics).
During treatment is not recommended to take ethanol (perhaps a sharp decrease in blood pressure).
Timolol increases the effects of peripheral muscle relaxants, so the necessary removal of the drug 48 hours before planned surgery with general anesthesia.
Overdose
Perhaps the development obscherezorbtivnyh effects typical of beta-blockers: dizziness, headache, arrhythmia, bradycardia, bronchospasm, nausea, vomiting.
Treatment: rinse immediately with water or 0.9% sodium chloride solution, symptomatic therapy.
pharmachologic effect
Pharmacological group:
Antiglaucoma agents – beta-blocker.
Pharmacodynamics:
Timolol is a non-selective blocker of beta-adrenergic receptors. It has no intrinsic sympathomimetic and membrane stabilizing activity.
When applied topically as eyedrops reduce both normal and elevated intraocular pressure by decreasing the formation of intraocular fluid. It has no effect on pupil size and accommodation.
The action of the drug is 20 minutes after instillation into conjunctival cavity. The maximum decrease in IOP occurs within 1-2 hours and lasts for 24 hours.
Pharmacokinetics:
When applied topically, timolol rapidly penetrates through the cornea. After instillation of the eye drops the maximum concentration of timolol achieved in 1-2 hours in the aqueous humor of the anterior chamber.
The small amount enters the systemic circulation by absorption through the vessels of the conjunctiva, the lacrimal and the nasal mucosa tract. Timolol excretion of metabolites is done primarily by the kidneys.
In newborns and adults malenkihdeteymaksimalnayakontsentratsiyasuschestvennoprevyshaettakovuyu in plasma.
Pregnancy and breast-feeding
Sufficient experience of use of the drug during pregnancy, lactation and children do not have, however, shown that timolol passes the placental barrier and enters the breast milk. Perhaps the use of the drug Okumed® for the treatment of children and pregnant women if the expected therapeutic effect is greater than the risk of possible side effects. During the use of the drug should stop breastfeeding.
Conditions of supply of pharmacies
On prescription.
side effects
Local reactions: irritation and redness of the conjunctiva, eyelid skin, burning and itchy eyes, watery eyes, or a decrease in lacrimation, photophobia, edema of the corneal epithelium, superficial punctate keratopathy, gipostezii cornea, diplopia, ptosis, dry eyes, a short break in visual acuity, blepharitis, conjunctivitis , keratitis. When conducting operations antiglaukomatoznyh may develop detachment of the choroid in the postoperative period.
Systemic reactions:
Cardio-vascular system: congestive heart failure, bradycardia, bradyarrhythmia, decreased blood pressure, collapse, atrioventricular block, heart failure, transient ischemic attacks.
The respiratory system: dyspnea, bronchospasm, pulmonary insufficiency.
Central nervous system: headache, dizziness, myasthenia gravis, depression, paresthesia, drowsiness, hallucinations, tinnitus, slowing of psychomotor reactions.
On the part of the gastrointestinal tract: nausea, vomiting, diarrhea.
Allergic reactions: urticaria, eczema.
Rhinitis, nasal bleeding, chest pain, decreased potency, alopecia.
In the case of side effects, discontinue using the product as soon as possible and contact your doctor.
special instructions
Neobhodimoregulyarnoposeschatvrachadlyaizmereniyavnutriglaznogodavleniya and corneal examination.
If the patient wears contact lenses are soft, then it should not apply the eyedrops Okumed® 0.25% and 0.5% as preservative, can be sorbed soft contact lens material and have an adverse effect on the eye tissue.
It is hard to remove contact lenses before instillation of the preparation and putting them again only after 15 minutes.
Immediately after instillation of the drug may reduce visual acuity and slower mental reactions, which may reduce the ability to actively participate in road traffic, maintenance of machines, or to perform work without support. To an even greater extent this is the case, while the use of the drug with alcohol.
When transferring patients to treatment with timolol may need refractive error correction after effects caused by the previously used miotikami.
In the case of the upcoming surgery using general anesthesia is necessary to stop the drug for 48 hours.
Storage conditions
At temperatures above 25 ° C, protected from light. Do not freeze.
Keep out of the reach of children.
Dosing and Administration
Adults and children over 10 years instilled into the conjunctival sac of one drop of 0.25% solution of 2 times a day, the lack of effectiveness – 1 drop of 0.5% solution of 2 times a day. When the normalization of intraocular pressure maintenance dose – 1 drop of 0.25% 1 per day.
Children up to 10 years – 1 drop of 0.25% solution of 2 times a day.
Treatment with Okumed® held, as a rule, for a long time. Suspension or change the dosage are carried out only by order of a physician.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist