Oktolipen caps. 300mg 30 pieces

$6.88

Oktolipen caps. 300mg 30 pieces

Quantity:

Description

Composition
Active substance:
1 capsule contains: thioctic acid (alpha-lipoic acid) – 300 mg.
Excipients:
Calcium phosphate dibasic (calcium hydrogenphosphate), pregelatinized starch, Aerosil (colloidal silica), magnesium stearate in the pharmaceutical industry.
Capsules Composition: a body and a lid – medical gelatin, titanium dioxide (E 171), quinoline yellow (E 104), coloring agent sunset yellow (E 110).
Description:
Solid opaque gelatin capsules № 0 yellow.
Contents of capsules – powder light yellow or yellow. Admitted white blotches.
Product form:
Capsules 300 mg.
10 capsules in blisters. 3 or 6 outline packages with instructions for use in a pile of cardboard.
Contraindications
Increased sensitivity to the drug; Children up to age 18 years (effectiveness and safety have not been established); Pregnancy and breast-feeding.
Dosage
300 mg
Indications
Diabetic neuropathy; alcoholic polyneuropathy.
Interaction with other drugs
While the use of insulin and other oral hypoglycemic agents for enhancing the hypoglycemic effect is observed.
After morning reception thioctic acid take iron, magnesium, as well as to consume dairy products (due to the calcium contained therein) is recommended in the afternoon or evening.
Ethanol reduces the therapeutic efficacy of thioctic acid.
Overdose
Symptoms: headache, nausea, vomiting.
Treatment: symptomatic. No specific antidote.
pharmachologic effect
Pharmacological group:
Metabolic means.
Pharmacological properties:
Thioctic acid (alpha-lipoic acid) – endogenous antioxidant (binds free radicals) in the body formed by the oxidative decarboxylation of alpha-keto acids. As coenzyme mitochondrial multienzyme complexes involved in the oxidative decarboxylation of pyruvic acid and alpha-keto acids. Thereby reducing the concentration of glucose in the blood and increased glycogen content in the liver, as well as overcome the insulin resistance. By the nature of the biochemical actions similar to B vitamins involved in the regulation of lipid and carbohydrate metabolism, stimulates cholesterol metabolism, improves liver function. It has hepatoprotective, lipid-lowering, cholesterol-lowering, hypoglycemic effect. Improves the trophism of neurons and axonal conduction reduces the manifestations of diabetic and alcoholic polyneuropathy.
Pharmacokinetics:
When ingestion rapidly and completely absorbed, the reception at the same time reduces the absorption of food. Bioavailability – 30-60% due to the effect of “first pass” through the liver. The time to reach maximum plasma concentration (TSmax) – 25-60 minutes. It is metabolized in the liver by the oxidation of side chain conjugation. Thioctic acid and its metabolites are excreted by the kidneys (80-90%). The half – 20-50 min. Total plasma clearance – 10-15 ml / min.
Conditions of supply of pharmacies
On prescription.
side effects
Allergic reactions: urticaria, systemic allergic reactions (up to the development of anaphylactic shock).
May develop symptoms of hypoglycemia (due to improved glucose uptake).
When ingestion possible diarrheal phenomenon, including nausea, vomiting, heartburn.
special instructions
In patients with diabetes, especially early in treatment, requires frequent monitoring of blood glucose levels. In some cases, a dose reduction of hypoglycemic agents.
During treatment must be strictly abstain from alcohol, as under the influence of alcohol therapeutic effect thioctic acid is attenuated.
Storage conditions
Store at a temperature not higher than 25 C.
Keep out of the reach of children.
Dosing and Administration
Inside, 600 mg (2 capsules) 1 time per day. Take an empty stomach, 30 minutes before the first meal, liquid squeezed a sufficient amount of water. The duration of treatment determined by the doctor.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

Pharmstandard BRANDS

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