Description
Composition
Active substance:
1 suppository contains: nystatin – 55.5 mg (250,000 U) and 111.0 mg (500,000 units).
Excipients:
Propyl (Nipasol) – 2.0 mg citric acid monohydrate – 0,075 mg, liquid paraffin (vaseline oil) – 10.0 mg.
Suppository bases: solid fat.
Contraindications
Hypersensitivity to the drug, children under 18 years (no data on the efficacy and safety of Nystatin in the rectal dosage form in children).
Indications
Treatment of rectal.
Prevention of fungal lesions of the rectum in the pre- and postoperative periods for surgical interventions.
Interaction with other drugs
When applied simultaneously with nystatin clotrimazole last activity decreases.
pharmachologic effect
Pharmacological group:
Antifungal agents.
Pharmacodynamics:
An antifungal agent, an antibiotic from the group of polyenes. By binding to sterols in the cell membrane of fungi, it violates its permeability, which leads to the output of the main components of the cell. Active against Candida albicans.
Pharmacokinetics:
It possesses weak resorptive effect. When applied topically, mucosally absorbed. Displayed through the intestines. Not accumulates.
Pregnancy and breast-feeding
Application is possible if the potential benefit to the mother outweighs the potential risk to the fetus and child. The drug is practically not absorbed through the lining of the rectum, so the breast milk does not penetrate. In the case of side effects should seek medical advice.
Conditions of supply of pharmacies
On prescription.
side effects
Diarrhea, abdominal pain, fever, chills, and allergic reactions.
Possible risk of the spread of drug-resistant forms of fungi, which requires discontinuation of the drug.
special instructions
Effects on ability to drive vehicles and management mechanisms.
In the period of treatment can be controlled vehicles and occupation of other potentially hazardous activities that require high concentration and psychomotor speed reactions.
Storage conditions
Stored in a dry place, protected from light at a temperature not higher than + 5 ° C.
Dosing and Administration
Suppository, previously freed from blisters with scissors (cutting the packaging along the contour of a suppository), injected deep into the rectum.
Adults: 1 suppository 2 times a day (morning and evening).
The course of treatment 10 – 14 days. The duration of treatment and the need for repeated courses determined by the physician.
In the prevention of fungal infections of the rectum in the pre- and postoperative periods during surgery treatment – 7 days.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist
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