Nurofen tab n / about 20 pcs 200mg

$3.50

Nurofen tab n / about 20 pcs 200mg

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Description

Composition
Active substance:
Ibuprofen 200 mg.
Excipients:
Sodium croscarmellose 30 mg Sodium lauryl sulfate 0.5 mg, sodium citrate dihydrate 43.5 mg stearic acid 2 mg Colloidal silica 1 mg.
shell composition: carmellose sodium 0.7 mg talc 33 mg, acacia gum 0.6 mg, 116.1 mg sucrose, 1.4 mg of titanium dioxide, Macrogol 6000 0.2 mg, black ink [S-1-277001 Opakod ] (28.225% shellac, a dye black iron oxide (E172) 24.65%, propylene glycol 1.3% isopropanol * 0.55% * 9.75% butanol, ethanol * 32.275% purified water * 3.25% ).
* The solvents evaporate after printing process.
Description:
Round, biconvex tablets, coated white or almost white color with black color overprint Nurofen at one side of the tablet. The cross-sectional core tablet White or almost white, shell white or nearly white.
Product form:
10 tablets in a blister (PVC / PVDC / Aluminum). Two blisters (10 tablets), together with instructions for use placed in a cardboard box or plastic container.
Contraindications
– erosive and ulcerative lesions of the gastrointestinal tract in the acute phase, including peptic ulcer and 12 duodenal ulcer in the acute stage, ulcerative colitis, peptic ulcer, Crohn’s disease;
– heart failure;
– severe course of hypertension;
– hypersensitivity to ibuprofen or to the drug;
– complete or incomplete syndrome intolerance of acetylsalicylic acid (rhinosinusitis, urticaria, polyps, nasal mucosa, bronchial asthma);
– diseases of the optic nerve; impaired color vision, amblyopia, scotoma;
– deficiency of glucose-b-phosphate dehydrogenase, hemophilia and other bleeding disorders, hemorrhagic diathesis, anticoagulation status – III trimester pregnancy, lactation;
– expressed human liver;
– severe renal impairment (creatinine clearance less than 30 mL / min);
– hearing loss, the pathology of the vestibular apparatus;
– the period after coronary artery bypass surgery;
– gastro-intestinal bleeding and intracranial hemorrhage;
– hemophilia and other bleeding disorders, hemorrhagic diathesis;
– children up to 6 years.
Carefully:
advanced age, coronary heart disease, cerebrovascular disease, dyslipidemia, diabetes, diseases of peripheric arteries, smoking, frequent alcohol use, prolonged use of NSAIDs, severe somatic diseases, concomitant use of oral corticosteroids (in Vol. h. prednisone), anticoagulants (including . h. warfarin, clopidogrel, aspirin), receiving selective serotonin reuptake inhibitor, diseases when receiving the drug in patients with gastric ulcer and duodenum 12 in anam EZE, gastritis, enteritis, colitis, with anamnestic information about bleeding from the gastrointestinal tract; in the presence of accompanying diseases of the liver and / or kidney; liver cirrhosis with portal hypertension, nephrotic syndrome, chronic heart failure; hypertension; in blood diseases of unknown etiology (leukopenia and anemia); bronchial asthma, hyperbilirubinemia; pregnancy (I, II trimesters); age under 12 years.
Dosage
200 mg
Indications
Nurofen used for dental pain and headache, migraine, painful menstruation, neuralgia, back pain, muscular and rheumatic pain; as well as feverish with the flu and colds.
Interaction with other drugs
It should avoid the simultaneous use of ibuprofen with the following drugs:
Acetylsalicylic acid: with the exception of low-dose acetylsalicylic acid (not more than 75 mg per day), prescribed by the doctor, since the combined use may increase the risk of side effects. With simultaneous use of ibuprofen reduces inflammatory and antiplatelet effect of acetylsalicylic acid (may increase the incidence of acute coronary insufficiency in patients receiving as antiplatelet agents acetylsalicylic acid, low dose, after initiation of ibuprofen).
Other NSAIDs, in particular, selective COX-2 inhibitors: avoid simultaneous use of two or more agents from the group of NSAIDs due to possible increased risk of side effects.
Precautions used simultaneously with the following drugs:
Anticoagulants and thrombolytic drugs: NSAIDs may enhance the effect of anticoagulants, particularly warfarin and thrombolytic agents.
Antihypertensive agents (ACE inhibitors and angiotensin II) and diuretics NSAIDs may reduce efficacy of these groups. In some patients with impaired renal function (e.g., patients with dehydration or in elderly patients with impaired renal function) co-administration of ACE inhibitors or antagonists of angiotensin II and agents that inhibit cyclooxygenase, may lead to a deterioration of renal function, including the development of acute renal failure (usually reversible). These interactions should be considered in patients taking coxibs simultaneously with ACE inhibitors or angiotensin II. Therefore, the combined use of the above means should be used with caution, especially in the elderly. It is necessary to prevent dehydration in patients, and consider monitoring renal function after initiation of such combination therapy and periodically thereafter. Diuretics and ACE inhibitors may increase the nephrotoxicity of NSAIDs.
Steroids: increased risk of gastrointestinal ulcers and gastrointestinal bleeding.
Antiplatelet agents and selective serotonin reuptake inhibitors: increased risk of gastrointestinal bleeding.
Cardiac glycosides: co-administration of NSAIDs and cardiac glycosides can lead to aggravation of heart failure, decreased glomerular filtration rate and an increase in concentration of cardiac glycosides in blood plasma.
of lithium drugs: there is evidence of the likelihood of increasing the concentration of lithium in blood plasma during treatment with NSAIDs.
Methotrexate: there is evidence of the likelihood of increasing concentration of methotrexate in the blood plasma during treatment with NSAIDs.
Cyclosporin: increased risk of nephrotoxicity with concomitant administration of NSAIDs and cyclosporine.
Mifepristone: NSAIDs should be started no earlier than 8-12 days after mifepristone administration as NSAIDs can reduce the efficacy of mifepristone.
Tacrolimus: while the appointment of NSAIDs and tacrolimus may increase the risk of nephrotoxicity.
Zidovudine: simultaneous application of NSAIDs and zidovudine could result in increased gematotoksichnosti. There is evidence of increased risk of haemarthrosis and hematoma in HIV-positive patients with hemophilia who received co-treatment with zidovudine and ibuprofen.
Quinolone antibiotics series: patients receiving collaborative care NSAIDs and quinolone antibiotics series, may increase the risk of seizures.
Myelotoxic drugs: increased gematotoksichnosti.
Cefamandole, cefoperazone, cefotetan, valproic acid, plicamycin: an increase in the incidence hypoprothrombinemia.
Drugs that block tubular secretion: reducing clearance and increase plasma concentrations of ibuprofen.
Inductors microsomal oxidation (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants): increased production of active hydroxylated metabolites increased risk of severe intoxication.
Inhibitors of microsomal oxidation: reducing the risk of hepatotoxicity.
Oral hypoglycemic drugs and insulin, sulfonylurea derivatives: potentiation of drugs.
Antacids and cholestyramine: reduced absorption.
Uricosuric drugs: reduction of drug efficacy.
Caffeine: increased analgesic effect.
Overdose
In children, the symptoms of overdose may occur after ingestion of a dose exceeding 400 mg / kg body weight. In adults, a dose-dependent effect of an overdose is less pronounced. The half-life of the drug overdose is 1.5-3 hours.
Symptoms include nausea, vomiting, epigastric pain, or more rarely, diarrhea, tinnitus, headache and gastrointestinal bleeding. In more severe cases, there are manifestations of the central nervous system: drowsiness, rarely agitation, convulsions, disorientation, coma. In cases of severe poisoning can develop metabolic acidosis and increased prothrombin time, kidney failure, liver damage tissue, blood pressure, respiratory depression and cyanosis. Patients with asthma may increase the disease.
Treatment: symptomatic, with obligatory airway, ECG monitoring and vital signs up to the normalization condition of the patient. We recommend the use of activated charcoal oral or gastric lavage for 1 hours after administration of potentially toxic doses of ibuprofen. If ibuprofen has already been absorbed, it can be assigned to alkaline water with the aim of removing the acid derivative of ibuprofen kidney diuresis. Frequent or prolonged convulsions should be to stop the intravenous administration of diazepam or lorazepam. When deterioration of asthma recommend the use of bronchodilators.
pharmachologic effect
Pharmacological group:
nonsteroidal anti-inflammatory drug (NSAID)
Pharmacodynamics:
The mechanism of action of ibuprofen, the propionic acid derivative from the group of non-steroidal anti-inflammatory drugs (NSAIDs) is due to the inhibition of prostaglandin synthesis – mediators of pain, inflammation and hyperthermic response. Indiscriminately blocked cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2), thereby inhibits the synthesis of prostaglandins. It provides quick directional effect against pain (analgesic), antipyretic and anti-inflammatory effect. Furthermore, ibuprofen reversibly inhibits platelet aggregation.
The analgesic effect of the drug is continued until 8 hours.
Pharmacokinetics:
High absorption, is rapidly and almost completely absorbed from the gastrointestinal tract (GIT). After ingestion fasting maximum concentration (Cmax) in plasma of ibuprofen is achieved after 45 minutes. The drug together with food can increase the time to peak concentration (TSmax) of 1-2 hours. Communication with the plasma proteins 90%. Slowly into the joint cavity, it is retained in the synovial fluid, making it larger concentration than in blood plasma. In the cerebrospinal fluid found lower concentrations of ibuprofen compared with blood plasma. After absorption of about 60% pharmacologically inactive R-form is transformed slowly into the active S-shape. It is metabolized in the liver. The half-life (T1 / 2)
2 hours. Excreted by the kidneys (in unmodified form are not more than 1%) and, to a lesser extent in the bile.
In limited studies, ibuprofen was detected in breast milk in very low concentrations.
Pregnancy and breast-feeding
Use of the drug during pregnancy is possible only under medical supervision. Use during I, II trimesters is not desirable, but perhaps with caution. Application during the III trimester is contraindicated. Use of the drug during lactation is possible with caution.
Conditions of supply of pharmacies
Without recipe.
side effects
The risk of side effects can be minimized, if you take a short course of the drug in the lowest effective dose needed to control symptoms.
In the elderly there is an increased frequency of adverse reactions to treatment with NSAIDs, especially gastrointestinal bleeding and perforation, in some cases fatal.
Side effects are mainly dose dependent.
The following adverse reactions were observed at short ibuprofen in doses not to exceed 1200 mg / day (6 tablets).
In the treatment of chronic conditions and long-term use may cause other adverse reactions.
estimates of frequency of adverse reactions produced on the basis of the following criteria: very common (> 1/10), frequent (by> 1/100 to 1/1000 and 1/10 000
Blood disorders and lymphatic system
Very rare: disturbances of hematopoiesis (anemia, leukopenia, aplastic anemia, hemolytic anemia, thrombocytopenia, pancytopenia, agranulocytosis). The first symptoms of such disorders are fever, sore throat, superficial oral ulcers, flu-like symptoms, severe weakness, nosebleeds and bruising, bleeding, and bruising of unknown etiology.
Violations by the immune system
Infrequent: hypersensitivity reactions – nonspecific allergic reactions and anaphylactic reaction by the airway reactions (asthma, including its exacerbation, bronchoconstriction, dyspnea, dyspnea), skin reactions (pruritus, urticaria, purpura, angioedema, exfoliative and bullous dermatoses , including toxic epidermal necrolysis (Lyell’s syndrome), Stevens-Johnson syndrome, erythema multiforme), allergic rhinitis, eosinophilia.
Very rare: hypersensitivity severe reactions, including swelling of the face, tongue and throat, shortness of breath, tachycardia, hypotension (anaphylaxis, angioedema or severe anaphylactic shock).
Disorders of the gastrointestinal tract
Uncommon: abdominal pain, nausea, dyspepsia (including heartburn, bloating).
Rare: diarrhea, flatulence, constipation, vomiting.
Very rare: peptic ulcer, perforation or gastrointestinal bleeding, melena, bloody vomiting, in some cases fatal, especially in elderly patients, ulcerative stomatitis, gastritis.
Frequency unknown: exacerbation colitis and Crohn’s disease.
Disorders of the liver and biliary tract
Very rare: abnormal liver function, increased activity of “liver” transaminases, hepatitis and jaundice.
Violations of the kidneys and the urinary tract
Rare: acute renal failure (compensated and decompensated) especially in long-term use, in combination with increasing concentrations of urea in the blood plasma and the appearance of edema, proteinuria and hematuria, nephritic syndrome, nephrotic syndrome, papillary necrosis, interstitial nephritis, cystitis.
Disorders of the nervous system
Uncommon: headache.
Very rare: aseptic meningitis.
Violations of the cardiovascular system
Frequency is unknown: heart failure, peripheral edema, with prolonged use at increased risk of thrombotic complications (e.g., myocardial infarction), hypertension.
Violations of the respiratory system and organs of the mediastinum
Frequency not known: bronchial asthma, bronchospasm, dyspnea.
Laboratory parameters hematocrit or hemoglobin (may be reduced)
Bleeding time (may be increased)
concentration in plasma glucose (may decrease)
creatinine clearance (may decrease)
plasma creatinine concentration (may be increased)
Activity “liver” enzymes (may be increased)
When side effects should stop taking the drug and consult a doctor.
special instructions
During long-term treatment is required to monitor patterns of peripheral blood and functional state of the liver and kidneys. When symptoms gastropathy shown careful control, comprising carrying esophagogastroduodenoscopy, total blood (hemoglobin), analysis of fecal occult blood. If necessary, the definition of 17-ketosteroids drug should be discontinued 48 hours prior to the study. Patients should refrain from all activities related to driving and working with moving machinery, as well as other kinds of potentially dangerous activities associated with the concentration and increased speed of psychomotor reactions.
During the period of treatment should refrain from drinking alcohol.
Effects on ability to transp. Wed. and fur .:
Patients should refrain from all activities related to driving and working with moving machinery, as well as other kinds of potentially dangerous activities associated with the concentration and increased speed of psychomotor reactions.
Storage conditions
Stored in a dry place at a temperature not exceeding 25 ° C.
Store this medication out of reach of children!
Dosing and Administration
For ingestion. Patients with increased sensitivity of the stomach is recommended to take the drug at meal time.
Only for short-term use. Please read the instructions before taking the drug.
Adults and children over 12 years: inside 1 tablet (200 mg) 3-4 times a day. The tablets should be taken with water. To achieve a rapid therapeutic effect in the adult dose may be increased to two tablets (400 mg) 3 times a day.
Children from 6 to 12 years: 1 tablet (200 mg) 3-4 times a day; drug can be taken only when the baby up to 20 kg body weight.
The interval between the reception of the tablets must be at least 6 hours.
The maximum daily dose for adults is 1200 mg (6 tablets). The maximum daily dose for children 6 to 18 years: 800 mg (4 tablets).
If you are taking the drug for 2-3 days the symptoms persist or intensify, it is necessary to stop treatment and seek medical advice.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

Nurofen

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