Nurofen Express forte caps. 400mg 10 pieces

$4.40

Nurofen Express forte caps. 400mg 10 pieces

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Description

Composition
Active substance:
Ibuprofen 400 mg.
Excipients:
Macrogol 600 – 335.3 mg, of potassium hydroxide – 44.82 mg Water – 29.88 mg.
shell composition: gelatin – 197 mg sorbitol (partially dehydrated) – 95.68 mg Water – 25.02 mg carmine dye [Ponceau 4R] (E124) – 0.79 mg, white ink [Opakod WB NS-78-18011] (water – 48 % titanium dioxide (E171) – 29% propylene glycol – 10% isopropanol – 8%, hypromellose 3cP – 5%).
Description:
Capsules soft gelatinous, oval, semi-transparent red color, with an inscription identifying “NUROFEN” white; contents Capsule – transparent liquid from colorless to pale pink.
Product form:
4 things. – blisters (1) – packs cardboard. 4 things. – blisters (2) – packs cardboard. 8 pcs. – blisters (1) – packs cardboard. 8 pcs. – blisters (2) – packs cardboard. 10 pieces. – blisters (1) – packs cardboard. 10 pieces. – blisters (2) – packs cardboard. 10 pieces. – blisters (3) – packs cardboard.
Contraindications
– hypersensitivity to ibuprofen or any of the components comprising the drug; – full or partial combination of asthma, recurrent nasal polyposis, and paranasal sinuses, and intolerance to acetylsalicylic acid or other NSAIDs (including history); – erosive-ulcerous diseases of the intestine (including gastric ulcer and duodenal ulcer, Crohn’s disease, ulcerative colitis), or ulcer bleeding or active phase history (confirmed by two or more episodes of peptic ulcer or ulcer bleeding); – bleeding or perforation, gastrointestinal ulcer history provoked NSAIDs; – severe liver failure or liver disease in active phase; – severe renal insufficiency severity (CC
Precautions for the use of
In the presence of the conditions referred to in this section should consult a physician before using the product.
Simultaneous treatment with other NSAIDs, a history of a single episode of gastric ulcer or gastrointestinal bleeding ulcer; gastritis, enteritis, colitis, the presence of infection Helicobacter pylori, ulcerative colitis; bronchial asthma or allergic disease in the acute phase, or a history – may develop bronchospasm; systemic lupus erythematosus or mixed connective tissue disease (Sharp’s syndrome) – increased risk of aseptic meningitis; renal failure, including by dewatering (CC less than 30-60 ml / min), nephrotic syndrome, liver failure, cirrhosis with portal hypertension, hyperbilirubinemia, hypertension and / or heart failure, cerebrovascular disease, blood disease of unknown etiology (leucopenia and anemia), severe somatic diseases, dyslipidemia / hyperlipidemia, diabetes mellitus, peripheral arterial disease, smoking, frequent alcohol use, phenylketonuria, or intolerant of phenylalanine, the simultaneous use of medical preparation own funds that may increase the risk of ulcers or bleeding, in particular, oral corticosteroids (including prednisone), anticoagulants (including warfarin), selective serotonin reuptake inhibitors (including citalopram, fluoxetine , paroxetine, sertraline) or antiplatelet agents (including acetylsalicylic acid, clopidogrel), I-II trimesters of pregnancy, breastfeeding, older age.
Dosage
400 mg
Indications
– headache; – migraine; – toothache; – painful menstruation; – neuralgia; – back pain; – muscle pain; – rheumatic pain; – fever with the flu and colds.
Interaction with other drugs
It should avoid the simultaneous use of ibuprofen with the following drugs
Acetylsalicylic acid: with the exception of low-dose acetylsalicylic acid (not more than 75 mg / day), prescribed by the doctor, since the combined use may increase the risk of side effects. With simultaneous use of ibuprofen reduces inflammatory and antiplatelet effect of acetylsalicylic acid (may increase the incidence of acute coronary insufficiency in patients receiving as antiplatelet agents acetylsalicylic acid, low dose, after initiation of ibuprofen).
Other NSAIDs, in particular, selective COX-2 inhibitors: avoid simultaneous use of two or more agents from the group of NSAIDs due to possible increased risk of side effects.
Precautions used simultaneously with the following drugs
Anticoagulants and thrombolytic drugs: NSAIDs may enhance the effect of anticoagulants, particularly warfarin and thrombolytic agents.
Antihypertensive agents (ACE inhibitors and angiotensin II) and diuretics NSAIDs may reduce efficacy of these groups. Diuretics and ACE inhibitors may increase the nephrotoxicity of NSAIDs.
SSC: increased risk of gastrointestinal ulcers and gastrointestinal bleeding.
Antiplatelet agents and selective serotonin reuptake inhibitors: increased risk of gastrointestinal bleeding.
Cardiac glycosides: co-administration of NSAIDs and cardiac glycosides can lead to aggravation of heart failure, decreased glomerular filtration rate and an increase in concentration of cardiac glycosides in blood plasma.
of lithium drugs: there is evidence of the likelihood of increasing the concentration of lithium in blood plasma pas treatment with NSAIDs.
Methotrexate: there is evidence of the likelihood of increasing concentration of methotrexate in the blood plasma during treatment with NSAIDs.
Cyclosporin: increased risk of nephrotoxicity with concomitant administration of NSAIDs and cyclosporine.
Mifepristone: NSAIDs should be started no earlier than 8-12 days after mifepristone administration as NSAIDs can reduce the efficacy of mifepristone.
Tacrolimus: while the appointment of NSAIDs and tacrolimus may increase the risk of nephrotoxicity.
Zidovudine: simultaneous application of NSAIDs and zidovudine could result in increased gematotoksichnosti. There is evidence of increased risk of haemarthrosis and hematoma in HIV-positive patients with hemophilia who received co-treatment with zidovudine and ibuprofen.
Quinolone antibiotics series: patients receiving collaborative care NSAIDs and antibiotics hnnolonovogo series, may increase the risk of seizures.
Cefamandole, cefoperazone, cefotetan, valproic acid, plicamycin: an increase in the incidence hypoprothrombinemia.
Drugs that block tubular secretion: reducing clearance and increase plasma concentrations of ibuprofen.
Inductors microsomal oxidation (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants): increased production of active hydroxylated metabolites increased risk of severe intoxication.
Inhibitors of microsomal oxidation: reducing the risk of hepatotoxicity.
Oral hypoglycemic drugs sulfonylureas and insulin: enhancement effect.
Antacids and cholestyramine: reduced absorption.
Caffeine: increased analgesic effect.
Overdose
In children, the symptoms of an overdose may occur after receiving the vines exceeding 400 mg / kg body weight. In adults, a dose-dependent effect of an overdose is less pronounced. T1 / 2 drug overdose is 1.5-3 hours.
Symptoms include nausea, vomiting, epigastric pain, or more rarely, diarrhea, tinnitus, headache and gastrointestinal bleeding. In more severe cases, there are manifestations of the central nervous system: drowsiness, rarely – excitement, convulsions, disorientation, coma. In cases of severe poisoning can develop metabolic acidosis and increased prothrombin time, kidney failure, liver damage tissue, decrease blood pressure, respiratory depression and cyanosis. Patients with asthma may increase the disease.
Treatment: symptomatic, with obligatory airway, ECG monitoring and vital signs up to the normalization condition of the patient. We recommend the use of activated charcoal oral or gastric lavage for 1 h after administration of potentially toxic doses of ibuprofen. If ibuprofen has already been absorbed, it can be assigned to alkaline water with the aim of removing the acid derivative of ibuprofen kidney diuresis. Frequent or prolonged convulsions should be cut short in / diazepam or lorazepam. When deterioration of asthma recommend the use of bronchodilators.
pharmachologic effect
Pharmacological group:
NSAIDs.
Pharmacological properties:
The mechanism of action of ibuprofen, the propionic acid derivative from the group of non-steroidal anti-inflammatory drugs (NSAIDs) is due to the inhibition of prostaglandin synthesis – mediators of pain, inflammation and hyperthermic response. Indiscriminately blocking COX-1 and COX-2, thereby inhibits the synthesis of prostaglandins. It provides quick directional effect against pain (analgesic), antipyretic and anti-inflammatory effect. Furthermore, ibuprofen reversibly inhibits platelet aggregation.
Pharmacokinetics:
Absorption and distribution
Absorption – high, rapidly and almost completely absorbed from the gastrointestinal tract. After receiving two capsules of the preparation fasting ibuprofen found in blood plasma after 15 min, Cmax ibuprofen plasma levels achieved after 30-40 min, which is 2 times faster than after ingestion of an equivalent dose Nurofen drug in the dosage form of a tablet coated obolchka 200 mg. The drug together with food can increase Tmax.
Plasma protein binding above 90%. Slowly into the joint cavity, it is retained in the synovial fluid, making it larger concentration than in blood plasma.
Metabolism and excretion
After absorption of about 60% pharmacologically inactive R-form is transformed slowly into the active S-shape. It is metabolized in the liver. T1 / 2 -. 2 hours excreted by the kidneys (unchanged no more than 1%) and, to a lesser extent in the bile.
In limited studies, ibuprofen was detected in breast milk in very low concentrations.
Pharmacokinetics in special patient groups
Older people have not detected significant differences in the pharmacokinetic profile of the drug as compared to younger people.
Pregnancy and breast-feeding
Do not use this drug in the III trimester. It should avoid the use of the drug in the I-II trimester of pregnancy should consult a physician if necessary dose.
There is evidence that ibuprofen in small quantities can penetrate into breast milk without any adverse effects on the baby’s health, so it is usually in short-term need for the reception termination of breastfeeding does not arise. If necessary, long-term use of the drug should consult a doctor to decide on the termination of breastfeeding during treatment.
Information for women planning pregnancy: these drugs inhibit COX and prostaglandins, affect ovulation, disrupting the female reproductive function (reversible after discontinuation of treatment).
Conditions of supply of pharmacies
Without recipe.
side effects
The risk of side effects can be minimized, if you take a short course of the drug in the lowest effective dose needed to control symptoms.
Side effects are mainly dose dependent.
The following adverse reactions were observed at short ibuprofen in doses not to exceed 1200 mg / day (6 capsules). In the treatment of chronic conditions and long-term use may cause other adverse reactions.
estimates of frequency of adverse reactions produced on the basis of the following criteria: very common (> 1/10), common (by> 1/100 to
special instructions
It is recommended to take the drug the maximum possible short-course, and in the lowest effective dose needed to control symptoms.
During long-term treatment is required to monitor patterns of peripheral blood and functional state of the liver and kidneys. When symptoms gastropathy shown careful control, comprising carrying esophagogastroduodenoscopy, total blood (hemoglobin), analysis of fecal occult blood. If necessary, definition of 17-ketosteroids drug should be discontinued 48 hours before the study. During the period of treatment is not recommended intake of ethanol.
Patients with renal failure should consult a physician before using the product, since there is a risk of deterioration of renal function.
Patients with hypertension, including history and / or chronic heart failure, it is necessary to consult a physician before using the drug as the drug can cause fluid retention, increased blood pressure and edema.
Effects on ability to drive vehicles and management mechanisms
Patients marking dizziness, drowsiness, confusion or visual disturbances while taking ibuprofen, should avoid driving vehicles or machinery control.
Storage conditions
The drug should be kept out of reach of children at a temperature not higher than 25 ° C.
Dosing and Administration
Carefully read the instructions before taking the drug.
For ingestion. Only for short-term use.
Adults and children over 12 years: the interior of 200 mg (. 1 capsule) 3-4 times / day. Take a capsule without chewing, drinking water. The interval between doses of the drug should be 6-8 hours.
adult dose may be increased to 2 capsules to achieve faster therapeutic effect (400 mg) and 3 times / day.
The maximum daily dose is 1200 mg.
The maximum daily dose for children 12-17 years of age is 1,000 mg.
If you are taking the drug for 2-3 days the symptoms persist or intensify, it is necessary to stop treatment and seek medical advice.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

Nurofen

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