Nurofen Express caps. 200mg 16 pieces

$5.80

Nurofen Express caps. 200mg 16 pieces

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Description

Composition
Active substance:
1 capsule contains: 200 mg of ibuprofen.
Excipients:
Macrogol-600 218.33 mg Potassium hydroxide 25.6 mg Water 17.07 mg; capsule shell: gelatin 119.8 mg, 76% sorbitol solution 58.19 mg carmine dye [Ponceau 4R] (E124) 0.485 mg Water 15.02 mg, white ink [Opakod WB NS-78-18011] (water 48 % titanium dioxide (E171) 29% propylene glycol 10%, 8% isopropanol, 5% hypromellose).
Description:
Soft oval translucent capsules with red gelatin shell, labeled with the identification of white NUROFEN, containing a clear liquid from colorless to pale pink.
Product form:
Capsules 200 mg.
Packing 8 or 16 capsules.
Contraindications
Hypersensitivity to ibuprofen or any of the components included in the formulation.
Full or partial combination of asthma, recurrent nasal polyposis, and paranasal sinuses, and intolerance to acetylsalicylic acid and other non-steroidal anti-inflammatory drugs (including history).
Erosive and ulcerative diseases of the gastrointestinal (including gastric ulcer and duodenal ulcer disease, Crohn’s disease, ulcerative colitis) or ulcer bleeding in the active phase or in history (two or more episodes of proven peptic ulcer or bleeding ulcer).
Bleeding or perforation of ulcers of the gastrointestinal tract in history, triggered by the use of NSAIDs.
Severe heart failure (NYHA class IV – classification of New York Heart Association).
Severe liver failure or liver disease in active phase.
Renal failure, severe severity (creatinine clearance
Decompensated heart failure; period after coronary artery bypass grafting.
Or other cerebrovascular bleeding.
Hemophilia and other bleeding disorders (including hypocoagulation), hemorrhagic diathesis.
Fructose intolerance.
Pregnancy (III trimester).
Children up to age 12 years.
Carefully:
In the presence of the conditions referred to in this section should consult a physician before using the product.
Simultaneous treatment with other NSAIDs, a history of a single episode of gastric ulcer or gastrointestinal bleeding ulcer; gastritis, enteritis, colitis, the presence of infection Helicobacter pylori, ulcerative colitis; bronchial asthma or allergic diseases in the acute stage or history – possibly bronchoconstriction; systemic lupus erythematosus or mixed connective tissue disease (Sharp’s syndrome) – increased risk of aseptic meningitis; chickenpox; renal failure, including during dehydration (creatinine clearance of less than 30-60 ml / min), nephrotic syndrome, liver failure, cirrhosis with portal hypertension, hyperbilirubinemia, hypertension and / or heart failure, cerebrovascular disease, blood disease of unknown etiology ( leukopenia and anemia), severe somatic diseases, dyslipidemia / hyperlipidemia, diabetes mellitus, peripheral arterial disease, smoking, frequent alcohol use, concomitant use lekars idents means which can increase the risk of ulcers or bleeding, in particular, oral corticosteroids (including prednisone), anticoagulants (including warfarin), selective serotonin reuptake inhibitors (including citalopram, fluoxetine, paroxetine, sertraline) or antiplatelet agents (including acetylsalicylic acid, clopidogrel), pregnancy I-II trimester, during breastfeeding, older age.
Dosage
200 mg
Indications
Nurofen Express is used for headache, migraine, dental pain, painful periods, neuralgia, back pain, muscular and rheumatic pain; in feverish conditions of the flu and colds.
Interaction with other drugs
Anticoagulants and thrombolytic drugs: NSAIDs may enhance the effect of anticoagulants, particularly warfarin and thrombolytic agents.
Antihypertensive agents (ACE inhibitors and angiotensin n) and diuretics NSAIDs may reduce efficacy of these groups. Diuretics and ACE inhibitors may increase the nephrotoxicity of NSAIDs.
Steroids: increased risk of gastrointestinal ulcers and gastrointestinal bleeding.
Antiplatelet agents and selective serotonin reuptake inhibitors: increased risk of gastrointestinal bleeding.
Cardiac glycosides: co-administration of NSAIDs and cardiac glycosides can lead to aggravation of heart failure, decreased glomerular filtration rate and an increase in concentration of cardiac glycosides in blood plasma.
of lithium drugs: there is evidence of the likelihood of increasing the concentration of lithium in blood plasma during treatment with NSAIDs.
Methotrexate: there is evidence of the likelihood of increasing concentration of methotrexate in the blood plasma during treatment with NSAIDs.
Cyclosporin: increased risk of nephrotoxicity with concomitant administration of NSAIDs and cyclosporine.
Mifepristone: NSAIDs should be started no earlier than 8-12 days after mifepristone administration as NSAIDs can reduce the efficacy of mifepristone.
Tacrolimus: while the appointment of NSAIDs and tacrolimus may increase the risk of nephrotoxicity.
Zidovudine: simultaneous application of NSAIDs and zidovudine could result in increased gematotoksichnosti. There is evidence of increased risk of haemarthrosis and hematoma in HIV-positive patients with hemophilia who received co-treatment with zidovudine and ibuprofen.
Quinolone antibiotics series: patients receiving collaborative care NSAIDs and quinolone antibiotics series, may increase the risk of seizures.
Cefamandole, cefoperazone, cefotetan, valproic acid, plicamycin: an increase in the incidence hypoprothrombinemia.
Drugs that block tubular secretion: reducing clearance and increase plasma concentrations of ibuprofen.
Inductors microsomal oxidation (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants): increased production of active hydroxylated metabolites increased risk of severe intoxication.
Inhibitors of microsomal oxidation: reducing the risk of hepatotoxicity.
Oral hypoglycemic drugs and insulin, sulfonylurea derivatives: strengthening effect.
Antacids and cholestyramine: reduced absorption.
Caffeine: increased analgesic effect.
It should avoid the simultaneous use of ibuprofen with the following drugs:
Acetylsalicylic acid: with the exception of low-dose acetylsalicylic acid (not more than 75 mg per day), prescribed by the doctor, since the combined use may increase the risk of side effects. With simultaneous use of ibuprofen reduces inflammatory and antiplatelet effect of acetylsalicylic acid (may increase the incidence of acute coronary insufficiency in patients receiving as antiplatelet agents acetylsalicylic acid, low dose, after initiation of ibuprofen).
Other NSAIDs, including selective inhibitors of COX-2 should avoid the simultaneous use of two or more drugs from the group of NSAIDs due to possible increased risk of side effects.
Overdose
In children, the symptoms of overdose may occur after ingestion of a dose exceeding 400 mg / kg body weight. In adults, a dose-dependent effect of an overdose is less pronounced. The half-life of the drug overdose is 1.5-3 hours.
Symptoms include nausea, vomiting, epigastric pain, or more rarely, diarrhea, tinnitus, headache and gastrointestinal bleeding. In more severe cases, there are manifestations of the central nervous system: drowsiness, rarely – excitement, convulsions, disorientation, coma. In cases of severe poisoning can develop metabolic acidosis and increased prothrombin time, kidney failure, liver damage tissue, blood pressure, respiratory depression and cyanosis. Patients with asthma may increase the disease.
Treatment: symptomatic, with obligatory airway, ECG monitoring and vital signs up to the normalization condition of the patient. We recommend the use of activated charcoal oral or gastric lavage for 1 hours after administration of potentially toxic doses of ibuprofen. If ibuprofen has already been absorbed, it can be assigned to alkaline water with the aim of removing the acid derivative of ibuprofen kidney diuresis. Frequent or prolonged convulsions should be to stop the intravenous administration of diazepam or lorazepam. When deterioration of asthma recommend the use of bronchodilators.
pharmachologic effect
Pharmacological group:
NSAIDs (nonsteroidal anti-inflammatory drug).
Pharmacodynamics:
The mechanism of action of ibuprofen, the propionic acid derivative from the group of non-steroidal anti-inflammatory drugs (NSAIDs) is due to the inhibition of prostaglandin synthesis – mediators of pain, inflammation and hyperthermic response. Indiscriminately blocked cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2), thereby inhibits the synthesis of prostaglandins. It provides quick directional effect against pain (analgesic), antipyretic and anti-inflammatory effect. Furthermore, ibuprofen reversibly inhibits platelet aggregation.
Pharmacokinetics:
Absorption – high, rapidly and almost completely absorbed from the gastrointestinal tract (GIT). After receiving two capsules of the preparation fasting ibuprofen found in blood plasma after 10 minutes, the maximum concentration (Cmax) in plasma of ibuprofen is achieved in 30-40 minutes, two times faster than after ingestion of an equivalent dose Nurofen drug in the dosage form of tablets, coated 200 mg. The drug with food can increase the time to reach maximum concentration (TSmah). Communication with plasma proteins than 90%, half-life (T1 / 2) – 2 hr. Slowly into the joint cavity, it is retained in the synovial fluid, making it larger concentration than in blood plasma. After absorption of about 60% pharmacologically inactive R-form is transformed slowly into the active S-shape. It is metabolized in the liver. Excreted by the kidneys (in unmodified form are not more than 1%) and, to a lesser extent in the bile.
Older people have not detected significant differences in the pharmacokinetic profile of the drug as compared to younger people.
In limited studies, ibuprofen was detected in breast milk in very low concentrations.
Pregnancy and breast-feeding
Do not use this drug in the III trimester. It should avoid the use of the drug in the I-II trimester of pregnancy should consult a physician if necessary dose. There is evidence that ibuprofen in small quantities can penetrate into breast milk without any adverse effects on the baby’s health, so it is usually in short-term need for the reception termination of breastfeeding does not arise. If necessary, long-term use of the drug should consult a doctor to decide on the termination of breastfeeding during treatment.
Conditions of supply of pharmacies
Without recipe.
side effects
The risk of side effects can be minimized, if you take a short course of the drug in the lowest effective dose needed to control symptoms.
Side effects are mainly dose dependent. The following adverse reactions were observed at short ibuprofen in doses not to exceed 1200 mg / day (6 capsules). In the treatment of chronic conditions and long-term use may cause other adverse reactions.
Qualification frequency of occurrence of adverse reactions performed on the basis of the following criteria: very frequent (> / = 10.1), frequent (from> / = 1/100 to / = 1/1000 before / 000 to 1/10 =
Blood disorders and lymphatic system
Very rare: disturbances of hematopoiesis (anemia, leukopenia, aplastic anemia, hemolytic anemia, thrombocytopenia, pancytopenia, agranulocytosis). The first symptoms of such disorders are fever, sore throat, superficial oral ulcers, flu-like symptoms, severe weakness, nosebleeds and bruising, bleeding, and bruising of unknown etiology.
Violations by the immune system
Infrequent: hypersensitivity reactions – nonspecific allergic reactions and anaphylactic reactions, by reaction airways (asthma, including its exacerbation, bronchoconstriction, dyspnea, dyspnea), skin reactions (pruritus, urticaria, purpura, angioneurotic edema, and bullous exfoliative dermatoses, including toxic epidermal necrolysis (Lyell’s syndrome), Stevens-Johnson syndrome, erythema multiforme), allergic rhinitis, eosinophilia.
Very rare: hypersensitivity severe reactions, including swelling of the face, tongue and throat, shortness of breath, tachycardia, hypotension (anaphylaxis, angioedema or severe anaphylactic shock).
Disorders of the gastrointestinal tract
Uncommon: abdominal pain, nausea, dyspepsia (including heartburn, bloating).
Rare: diarrhea, flatulence, constipation, vomiting.
Very rare: peptic ulcer, perforation or gastrointestinal bleeding, melena, bloody vomiting, in some cases fatal, especially in elderly patients, ulcerative stomatitis, gastritis.
Frequency unknown: exacerbation colitis and Crohn’s disease.
Disorders of the liver and biliary tract
Rare: liver function disorders (especially with prolonged use), hepatitis and jaundice.
Violations of the kidneys and the urinary tract
Rare: acute renal failure (compensated and decompensated) especially in long-term use, in combination with increasing concentrations of urea in the blood plasma and the appearance of edema, proteinuria and hematuria, nephritic syndrome, nephrotic syndrome, papillary necrosis, interstitial nephritis, cystitis.
Disorders of the nervous system
Uncommon: headache.
Very rare: aseptic meningitis.
Violations of the cardiovascular system
Frequency is unknown: heart failure, peripheral edema, with prolonged use at increased risk of thrombotic complications (e.g., myocardial infarction), hypertension.
Violations of the respiratory system and organs of the mediastinum
Frequency not known: bronchial asthma, bronchospasm, dyspnea.
other
Very rare: edema, including peripheral.
Laboratory parameters – hematocrit or hemoglobin (may be reduced)
– Bleeding time (may be increased)
– the concentration of glucose in blood plasma (may decrease)
– Creatinine clearance (may decrease)
– plasma creatinine concentration (may be increased)
– the activity of “liver” transaminases (can be increased)
When side effects should stop taking the drug and consult a doctor.
special instructions
It is recommended to take the drug the maximum possible short-course, and in the lowest effective dose needed to control symptoms.
During long-term treatment is required to monitor patterns of peripheral blood and functional state of the liver and kidneys. When symptoms gastropathy shown careful control, comprising carrying esophagogastroduodenoscopy, total blood (hemoglobin), analysis of fecal occult blood. Prien Parts Required determining 17-ketosteroids drug should be discontinued 48 hours prior to the study. During the period of treatment is not recommended intake of ethanol.
Patients with renal failure should consult a physician before using the product, since there is a risk of deterioration of renal function.
Patients with hypertension, including a history of and / or chronic heart failure, it is necessary to consult a physician before using the drug as the drug can cause fluid retention, hypertension and edema.
Patients with uncontrolled hypertension, congestive heart failure II-III class NYHA, ischemic heart disease, peripheral arterial disease and / or cerebrovascular disease prescribe ibuprofen should be only after a careful assessment of the benefit-risk, it should be to avoid the use of high doses of ibuprofen (> 2,400mg / day).
The use of NSAIDs in patients with varicella may be associated with an increased risk of severe septic complications infektsionnovospalitelnyh skin and subcutaneous fat (for example, necrotizing fasciitis). In this regard, it is recommended to avoid use of the drug varicella.
Information for women planning pregnancy: these drugs inhibit the cyclooxygenase and prostaglandin synthesis, affect ovulation, disrupting the female reproductive function (reversible after discontinuation of treatment).
Effects on ability to drive a vehicle engine.
Patients marking dizziness, drowsiness, confusion or visual disturbances while taking ibuprofen, should avoid driving vehicles or machinery control.
Storage conditions
Store at a temperature not higher than 25 C.
Store this medication out of reach of children.
Dosing and Administration
Please read the instructions before taking the drug.
For ingestion. Only for short-term use.
Adults and children over 12 years: 1 capsule (200 mg) is not liquid, up to 3-4 times a day. The capsule should be taken with water. The interval between doses of the drug should be 6-8 hours.
To achieve a rapid therapeutic effect in adults the single dose may be increased to two capsules (400 mg) 3 times a day.
The maximum daily dose is 1200 mg.
The maximum daily dose for children 12-17 years of age is 1,000 mg.
If you are taking the drug for 2-3 days the symptoms persist or intensify, it is necessary to stop treatment and seek medical advice.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

Nurofen

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