Nl enalapril 20mg + 12.5mg tabs 20 pcs ozone


Nl enalapril 20mg + 12.5mg tabs 20 pcs ozone



Active substance:
1 tablet contains hydrochlorothiazide – 12.5 mg, and enalapril maleate – 10.0 mg 1 tablet contains hydrochlorothiazide – 12.5 mg, and enalapril maleate – 20.0 mg.
Product form:
Tablets 12.5 mg + 10 mg + 12.5 mg or 20 mg of 10, 20 tablets in blisters of PVC film and aluminum foil printed patent. 10, 20, 30, 40, 50, 60, 70, 80, 90 or 100 tablets per plastic jars for medicaments. One jar or 1, 2, 3, 4, 5, 6, 8 or 10 contour of cellular packaging together with instructions for use placed in a pile of cardboard.
Hypersensitivity to enalapril or to other ACE inhibitors, hydrochlorothiazide or other derivatives of the sulfonamide or other components of the preparation, lactose intolerance, lactase deficiency syndrome or glucose-galactose malabsorption, anuria, angioneurotic edema history (including those associated with the use of ACE inV¬gibitorov) hereditary and / or idiopathic angioneurotic edema, severe liver function abnormalities (more than 9 points on the Child-Pugh), severe renal impairment (creatinine clearance less than 30 mL / min) beremennos Th, lactation, age under 18 years of age (efficacy and safety have not been established).
12.5 mg + 20 mg
Hypertension (patients in whom combination therapy is shown).
pharmachologic effect
Pharmacological properties:
Enalapril ACE inhibits, promotes conversion of angiotensin I into angiotensin II, reduces the concentration of aldosterone in blood plasma, increases the release of renin kallikreinkininovoy improves the functioning of the system, stimulates the release of prostaglandins and endothelial relaxing factor, inhibits the sympathetic nervous system. Collectively, these effects eliminate spasm and expand peripheral arteries, reduce the total peripheral vascular resistance, systolic and diastolic blood pres- sure (BP), and post-preload on the myocardium. Artery expands to a greater extent than the vein, the reflex increase in heart rate (HR) were not observed. The antihypertensive effect is more pronounced at high concentrations of renin in the blood plasma than in normal or reduced. Reduction of blood pressure in the therapeutic range has no effect on cerebral blood circulation. It improves blood flow to the ischemic myocardium. It enhances the renal blood flow, the glomerular filtration rate does not change. In patients with a baseline glomerular filtration, reduced its rate usually increases. The maximum effect of enalapril develops within 6 – 8 h. And maintained until 24 hours after ingestion.. Hydrochlorothiazide is a thiazide diuretic-average potency. It reduces the reabsorption of sodium ions at a level of the loop of Henle cortical segment without affecting its portion extending in the medulla of kidney. Blocks carbonic anhydrase in the proximal convoluted tubules, enhances renal excretion of potassium ions, phosphates and bicarbonates. Virtually no effect on acid-base status. It increases the excretion of magnesium ions. Delays in the body of calcium ions. The diuretic effect is developing after 12 hours, reaches a maximum after 4 hours, retained 10 – 12 h action decreases with a decrease in glomerular filtration rate and stops when its value less than 30 ml / min.. It reduces blood pressure by reducing blood volume (CBV), vascular reactivity changes. Use of a combination of enalapril and hydrochlorothiazide leads to greater reduction in blood pressure compared to monotherapy of each drug alone and allows to keep the antihypertensive effect of the drug enalapril H, at least for 24 hours.
Conditions of supply of pharmacies
Dosing and Administration
The drug enalapril NL should be taken regularly at the same time, preferably in the morning, regardless of the time of the meal, not liquid, squeezed small amount of liquid, 1 time per day. The recommended dose – 1 tablet per day. If necessary, the dose may be increased to two tablets taken once a day, this dosage is the maximum daily dose. Patients taking diuretics, it is recommended to cancel or reduce their dose, at least 3 days before the start of treatment with enalapril NL to prevent the development of symptomatic hypotension. Renal dysfunction in patients with severe renal failure (creatinine clearance less than 30 mL / min.) Drug contraindicated NL enalapril. In patients with renal insufficiency, with creatinine clearance of more than 30 ml / min., The formulation of enalapril IO may be applied only after the stabilization of blood pressure during treatment with drugs enalapril and hydrochlorothiazide in separate dosage forms, and selection of doses. The recommended initial dose of enalapril NL – 1 pill once a day. It should be monitored regularly (every two months) potassium, and creatinine.
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg

OZONE generics

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