Nitroksolin tab p / 50 mg of 50 pcs

Description

Composition
Active substance:
1 tablet contains: nitroksolin 50 mg.
Product form:
Coated tablets, 50 mg.
Contraindications
Renal dysfunction accompanied oligo- or anuria; severe hepatic disease; deficiency of glucose-6-phosphate dehydrogenase; Children under the age of three years (considering undivided solid dosage form), cataracts, neuritis, polyneuritis, pregnancy (III trimester), lactation. Hypersensitivity to drugs quinoline series.
Indications
Infectious and inflammatory diseases advantageously urinary tract (including pyelonephritis, cystitis, urethritis, epididymitis; infected adenoma or carcinoma of prostate, etc.)., Caused by susceptible microorganisms to nitroksolinu. Prevention of infectious complications in diagnostic and therapeutic procedures (catheterization, cystoscopy) in the postoperative period after surgical interventions on the kidney and the urogenital tract.
pharmachologic effect
Pharmacological group:
The antimicrobial agent – hydroxyquinoline.
Pharmacological properties:
Antimicrobial broad-spectrum. Nitroxoline selectively inhibits the synthesis of bacterial DNA, and has an effect on both gram-positive organisms: Staphylococcus spp. (Including S. aureus), Streptococcus spp. (Including beta-haemolytic streptococci, Streptococcus pneumoniae, Enterococcus faecalis), Corynebacterium diphtheriae, Bacillus subtilis; and the gram-negative organisms: N. gonorrhoeae, E. coli, Proteus spp, Klebsiella spp, Salmonella spp, Shigella spp, Enterobacter spp….. Nitroksolin also active against Mycobacterium tuberculosis, Trichomonas vaginalis, some species of fungi (Candida spp., Dermatophytes, mold, some pathogens of deep mycoses). Pharmacokinetics Absorption – high. Excreted by the kidneys in unchanged form, with a high concentration in urine (100 .mu.g / ml or more).
Conditions of supply of pharmacies
Prescription.
side effects
There may be nausea, vomiting, loss of appetite, it is very rare – allergic skin reactions. In rare cases – tachycardia, ataxia, headache, paresthesia, neuropathy, liver function abnormalities. With prolonged use, the case of the optic nerve neuritis.
special instructions
During treatment, the urine turns saffron-yellow.
Storage conditions
Store in a dry, dark place at a temperature not higher than 25 ° C.
Keep out of the reach of children.
Dosing and Administration
The drug is taken orally. For adults, a daily dosage of 400-800 mg. Multiplicity reception 3-4 times a day at intervals 6-8 hours. The course of treatment is 2-3 weeks. In chronic infections of the urinary tract drug can be administered repeatedly for 2 weeks with 2 weeks off. Average daily intake for children older than 5 years -0,2-0,4 g (0.05-0.1 g 4 times a day), younger than 5 years 0.2 grams per day. For the prevention of infections in kidney and urinary tract operations appoint 0.1 g reception 4 times a day for 2-3 weeks. Babies administered in a daily dose of 10-30 mg / kg 3-4 reception.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist