Nifedipine tab p / 10 mg film about 50 pieces of ozone

Description

Composition
Active substance:
1 tablet contains: 10 mg of nifedipine.
Product form:
Film-coated tablets 10 mg. 10, 25, 50 tablets in blisters of PVC film and aluminum foil printed patent. 10, 20, 30, 40, 50 or 100 tablets in a polymeric container for medicines. One container or 1, 2, 3, 4, 5 or 10 contour cell packages together with instructions for use placed in a pile of cardboard.
Contraindications
– Hypersensitivity; – arterial shipotenziya (systolic blood pressure below 90 mm Hg p.); – cardiogenic shock; – expressed aortic or subaortic stenosis; – unstable angina; – acute phase of myocardial infarction (within the first 4 weeks); – sick sinus syndrome; – AV blockade II-III art; – pregnancy (prior to 20 weeks), lactation; – the age of 18 years (effectiveness and safety have not been studied); – hereditary lactose intolerance, lactase deficiency syndrome glucose-galactose malabsorption (due to the presence of lactose).
Dosage
10 mg
Indications
Exertional angina and rest (including a variant); hypertension (alone or in combination with other antihypertensive agents).
pharmachologic effect
Pharmacological group:
Blocker “slow” calcium channels.
Pharmacological properties:
Nifedipine – selective blocker of the “slow” calcium channels, a derivative of 1,4-dihydropyridine. It has vasodilating, antianginal and hypotensive action. Decreases current of extracellular calcium ions into cardiomyocytes and smooth muscle cells of coronary and peripheral arteries; at high doses inhibits the release of calcium ions from intracellular stores. Reduces the number of operating channels, without affecting the time of activation, inactivation and recovery. Separates the excitation and contraction in the myocardium, tropomyosin and troponin mediated, and in vascular smooth muscle mediated by calmodulin. At therapeutic doses, current normalizes transmembrane calcium ions disturbed in several pathological states, especially in hypertension. It does not affect the tone of veins. Decreases spasm and dilates coronary and peripheral (mostly arterial) blood vessels, reducing blood pressure, total peripheral vascular resistance, decreases afterload tone infarction, myocardial oxygen demand and increases the duration of diastolic relaxation of the left ventricle. Increases coronary blood flow, improves blood flow to the ischemic myocardium zones without the development of the phenomenon of “steal”, activates the functioning of collaterals. Almost no effect on the sinoatrial and atrioventricular nodes and has no antiritmicheskoy activity. Negative chrono-, Drome and inotropic effect overlaps reflex activation of sympatic system and an increase in heart rate in response to peripheral vasodilation. It enhances the blood flow kidney, natriuresis is moderate. Time of onset of clinical effect 20 minutes, the duration of clinical effect of 4-6 hours.
Conditions of supply of pharmacies
Prescription.
Dosing and Administration
The mode set individually depending on the severity of the disease and the patient’s response to therapy. It is recommended to take the drug inside during or after a meal with a little water. Initial dose: 1 tablet (10 mg) 2-3 times a day. If necessary, the dose may be increased to two tablets (20 mg) – 1-2 times per day. The maximum daily dose is 40 mg. In elderly patients or patients receiving combination therapy, as well as abnormal liver function in patients with severely impaired cerebral circulation dose should be reduced.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist