Nicorette chewing gum 4mg 30 pieces fresh mint

$12.37

Nicorette chewing gum 4mg 30 pieces fresh mint

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Description

Composition
Active substance:
1, the chewing gum comprises: a nicotine-resin complex – 22 mg (equivalent to the specified number of 4.4 mg of nicotine, including 10% excess).
Excipients:
The core of chewing gum dosage:
chewing gum (base), * – 560 mg, xylitol – 302 mg Peppermint oil – 30 mg Sodium carbonate – 30 mg, acesulfame potassium – 2 mg, levomenthol – 2 mg Magnesium oxide – 1 mg, quinoline yellow E-104 – 1 mg;
Inner sheath:
flavoring «Winterfresh» – 9 mg hypromellose – 7.5 mg sucralose – 3.5 mg polysorbate 80 – 0.5 mg;
Sheath:
Xylitol – 277.5 mg pregelatinized starch – 6.5 mg, titanium dioxide – 6 mg, flavor «Winterfresh» – 5 mg, carnauba wax – 1 mg, quinoline yellow E-104 – 0,078 mg.
* Chewing gum base drug is a mixture of different types of waxes, resins, and other hydrocarbons (approximately 60%) and calcium carbonate (40%).
Description:
Square coated liner pale yellow to brownish or greenish tint pad measuring approximately 15h15h6 mm. Presence of small irregularities on the sides.
Taste: Fresh mint or frosty mint or fresh fruit.
Product form:
Chewing gum 4 mg dosage. 15 chewing gum medicaments in the blister. 1, 2 or 7 blister together with instructions for use in a cardboard package.
Contraindications
Increased sensitivity to nicotine or other components of the chewing gum.
Patients with impaired liver function and kidney
Chewing gum “Nikorette®” should be used with caution in patients with moderate or severe hepatic impairment, severe renal failure, exacerbation of duodenal ulcer and stomach.
Patients are to be taken with caution
Chewing gum “Nikorette®” should be applied only after consultation with the physician in patients with disorders of the cardiovascular system, in particular have suffered severe heart disease within 1 month before use (such as stroke, unstable angina, arrhythmia, myocardial infarction, bypass surgery or angioplasty) or uncontrolled hypertension.
Chewing gum “Nikorette®” should be used with caution in patients with moderate to severe liver dysfunction, severe renal impairment, exacerbation of peptic ulcer and duodenal zheludka.Nikotin entering the human body by therapy or smoking substitution, causes the release of catecholamines from the adrenal medulla . In connection with this chewing gum “Nikorette®” should be used with caution in patients with uncontrolled hyperthyroidism, pheochromocytoma, and diabetes.
The use of chewing gum “Nikorette®” is accompanied by a lower risk than smoking.
Dosage
4 mg
Indications
Treatment of tobacco dependence by reducing the need for nicotine in the following cases:
reducing the symptoms of “cancellation”, arising from the full smoking cessation in patients who have decided to quit smoking;
the temporary smoking cessation;
reducing the number of cigarettes smoked by those who can not or does not want to completely give up smoking.
Facilitates removal of the pigmented plaque on the teeth, it has a bleaching effect.
Interaction with other drugs
Clear clinically significant interaction between nicotine replacement therapy and other drugs is not established.
However, theoretically, nicotine may enhance the hemodynamic effects of adenosine, i.e. lead to increased blood pressure and heart rate, as well as enhance the response to pain (chest pain of angina pectoris on the type), provoked by administration of adenosine.
Overdose
Excessive intake of nicotine replacement therapy and / or smoking may cause overdosage symptoms.
Overdose symptoms similar to those of acute nicotine poisoning and include nausea, salivation, abdominal pain, diarrhea, sweating, headache, vertigo, impaired hearing and marked weakness. When high doses of nicotine can be marked decrease in blood pressure, weak and irregular pulse, labored breathing, circulatory collapse and generalized seizures.
Nicotine tolerated by adults smokers doses can cause in young children expressed symptoms of intoxication, including fatalities.
Treatment of overdose: Should immediately stop using nicotine and appoint symptomatic treatment. Activated charcoal reduces the absorption of nicotine in the gastrointestinal tract. If necessary, a mechanical ventilation and administered oxygen.
pharmachologic effect
Pharmacological group:
Means for treatment of nicotine addiction.
Pharmacodynamics:
After a sharp smoking cessation in patients routinely use tobacco-containing products for a long time, may develop the syndrome of “cancellation”, which includes: dysphoria, insomnia, irritability, anxiety, impaired concentration, decreased heart rate, increased appetite or weight gain. An important symptom of the syndrome of “cancellation” is also the desire to smoke.
In the treatment of tobacco dependence Nicotine replacement therapy reduces the need for a number of cigarettes smoked, reduces the severity of symptoms, “cancel”, arising from the full smoking cessation for those who have decided to quit smoking, facilitates temporary abstinence from smoking, as well as helps to reduce the number of cigarettes smoked in those who can not or will not completely give up smoking.
Pharmacokinetics:
Nicotine coming from gum rapidly absorbed through the mucosa of the mouth and is found in blood in 5-7 min. Maximum concentration of nicotine achieved 30 minutes after the start of chewing.
The volume of distribution of nicotine when administered intravenously equals about 2-3 l / kg, and elimination half-life -. About 2 hours Nicotine is mainly excreted by the liver, its average plasma clearance of about 70 l / h. Nicotine is metabolized in the kidneys and lungs. Identification of more than 20 metabolites of nicotine, which is inferior in activity.
Communication nicotine plasma protein is less than 5%. In this regard, disorders nicotine binding while the use of other drugs or changes in the concentration of plasma proteins in various diseases should not have a significant effect on the kinetics of nicotine.
The primary metabolite of nicotine, cotinine in plasma, has a half-life of 15-20 hours and its concentration exceeds that of nicotine by 10 times.
The urine cotinine derived mainly (15% of the dose) and trans-3-hydroxy-cotinine (45% of dose). From 10% to 30% of the nicotine dose excreted in the urine unchanged.
The progressive deterioration in renal function is accompanied by a decrease in total clearance of nicotine. Its pharmacokinetics unchanged in patients with cirrhosis slightly pronounced impaired hepatic function (5 points on the Child-Pugh) and decreased in cirrhotic patients with moderate hepatic impairment (7 points on the Child-Pugh). Smokers with concomitant chronic renal failure treated with hemodialysis, noted the increase in nicotine concentration in the blood plasma.
In elderly patients, there was a slight reduction in total clearance of nicotine that does not require a dose adjustment.
Pregnancy and breast-feeding
Smoking during pregnancy is associated with risks such as intrauterine growth retardation, premature birth or stillbirth. Quitting smoking is the single most effective intervention for improving the health of both the pregnant woman and her baby. Early cessation of smoking is the best option.
Nicotine crosses the placenta and is excreted in breast milk, and therefore its use may be dangerous to the fetus or child. Patients should be informed of the need to undertake failure attempt of smoking without nicotine replacement therapy. In case of failure of such attempts decision to conduct therapy is made after comparing the possible positive effects for the mother and the potential harm to the fetus.
Nicotine in small amount passes into breast milk even when administered at therapeutic doses, which may adversely affect the health of the child while taking the drug nursing mother. Therefore it is necessary to refrain from using the chewing gum “Nikorette®” during breastfeeding.
If you are unable to stop smoking, use of the drug should be started only after consulting your doctor. In order to reduce the negative influence of nicotine on the child’s gum “Nikorette®” should be used immediately after feeding.
side effects
Some symptoms may be caused as a result of the abolition of nicotine smoking cessation. These include: dysphoria or depressed mood, insomnia, irritability, frustration or anger, anxiety, difficulty concentrating, restlessness or impatience. Also, there may be other effects associated with smoking cessation: a decrease in heart rate, increased appetite or weight gain, dizziness or near syncope, cough, constipation, bleeding gums, or aphthous ulcers, nasopharyngitis. Craving for nicotine is regarded as clinically significant symptom – an important manifestation of nicotine withdrawal after smoking cessation.
Most adverse reactions observed in the early phase of treatment, and are preferably dose dependent.
In the first few days of treatment may be observed irritation of the oral mucosa and pharynx.
Continued treatment leads to adaptation.
In applying medicinal chewing gum “Nicorette” rarely develop allergic reactions (including anaphylaxis symptoms).
special instructions
Carefully
Chewing gum “Nikorette®” should be applied only after consultation with the physician in patients with disorders of the cardiovascular system, in particular have suffered severe heart disease within 1 month before use (such as stroke, unstable angina, arrhythmia, myocardial infarction, bypass surgery or angioplasty) or uncontrolled hypertension.
Chewing gum “Nikorette®” should be used with caution in patients with moderate or severe hepatic impairment, severe renal failure, exacerbation of duodenal ulcer and stomach.
Nicotine entering the human body at or smoking substitution therapy, induces the release of catecholamines from the adrenal medulla. In connection with this chewing gum “Nikorette®” should be used with caution in patients with uncontrolled hyperthyroidism, pheochromocytoma, and diabetes.
The use of chewing gum “Nikorette®” is accompanied by a lower risk than smoking.
Diabetics after smoking cessation may be required to decrease insulin doses.
Doses of nicotine that can be easily transferred to adult smokers and smokers, adolescents can cause severe intoxication in children, which can lead to death. It is important not to leave unattended preparations containing nicotine, because it may lead to incorrect use of their children and ingestion.
Polycyclic aromatic hydrocarbons contained in tobacco smoke induce metabolism of drugs metabolized isoenzyme CYP1A2 (and optionally, CYP1A1). Stopping smoking may cause slower metabolism and as a consequence, increased concentrations of these drugs in the blood. This has the potential clinical significance for drugs with a narrow therapeutic index, for example, theophylline, tacrine, clozapine and ropinirole.
For persons with impaired chewing function it is recommended to apply other dosage forms. Persons who use dentures may experience difficulty in chewing gum “Nikorette®”. Chewing gum may stick to dentures, and in rare cases, cause damage.
If the drug has come into disrepair or expiration date – do not throw it in the sewer system or into the street! Place the drug in the bag and place in the trash. These measures will help protect the environment!
Effects on ability to drive vehicles.
The effect on the ability to drive the vehicle and works with the mechanisms is not established.
Storage conditions
Store at a temperature not higher than 25 ° S.Hranit the reach of children.
Dosing and Administration
Adults and adolescents over 18 years
Dose selected individually depending on the intensity of smoking.
Usually:
• Chewing gum “Nikorette®” 2 mg (moderate nicotine content) should be used if you smoke less than 20 cigarettes per day,
• Chewing gum “Nikorette®” 4 mg (high nicotine content) should be used if you smoke more than 20 cigarettes a day, or you are unable to quit the application of gum at a dose of 2 mg.
How to use chewing gum “Nikorette®”
“Nikorette®” should be applied in all cases where there is an irresistible urge to smoke, according to the following scheme:
1. Chewing gum should be chewed for about 30 minutes with breaks. Slowly chew the gum until pronounced taste.
2. Stop chewing gum and leave it between the inner side of the cheek and gum.
3. When the taste disappears, start chewing gum again.
When the symptoms of overdose (see. Section “Overdose”) use of the drug should be discontinued immediately.
Complete cessation of smoking.
should chew at the same time only one pillow, stop smoking.
At full smoking cessation amount of chewing gum a day determined by the degree of dependence on nicotine, but is typically 8-12 units per day and should not exceed 15 units per day. Apply chewing gum at the indicated dose should be up to 3 months, after which the daily number of chewing gums should be reduced gradually to a complete “cancel.” The drug cease to apply when the daily dose is 1-2 pieces per day.
Regular use is usually not recommended chewing gum for more than 12 months, but some people need more long-term treatment, so as not to resume smoking.
Reducing the number of cigarettes smoked.
Chewing gum should be used according to needs between smoking episodes in order to increase the time intervals between smoking and with a view to the greatest possible reduction of smoking. If within 6 weeks has not succeeded in reducing the daily consumption of cigarettes, it is necessary to seek help from a specialist.
Quit attempt should be made as soon as you feel ready for it, but not later than 6 months after initiation of therapy. If you can not make a serious attempt to quit smoking within 9 months after the initiation of therapy, should see a specialist.
After smoking cessation therapy should follow the recommendations of gradual dose reduction and discontinuation of the drug, as defined above, with full smoking cessation.
Regular use of chewing gum is usually not recommended for more than 12 months. However, some ex-smokers may need longer treatment with the gum to avoid returning to smoking or tobacco use remains level.
Simultaneous medical counseling and psychological support normally improve the effectiveness of therapy.
Temporary cessation of smoking.
Chewing gum can be used at times when it is necessary to refrain from smoking, for example, while in places where smoking is prohibited, or in other situations where you need to refrain from smoking.
In combination with a transdermal patch.
Chewing gum “Nikorette®” dose of 2 mg may also be used in conjunction with the adhesive in those situations when the background of the patch man continues intermittently, or if you can not experience the irresistible urge to smoke to quit using only chewing gum or the patch only. In combination with adhesive gum “Nikorette®” dose of 2 mg allows you to quickly remove the strong urge to smoke when you need it. Patients should stop smoking completely during therapy.
Initial therapy:
The treatment should begin with the patch 25 mg / 16 hours (step 1) in combination with 2 mg chewing gum. When this is used as at least 4 Chewing gum 2 mg per day; It is usually sufficient to 5-6 chewing gums. Number of chewing gum should not exceed 15 units per day. Typically, the total course of treatment continues for 8 weeks. After that, the nicotine dose should be reduced gradually.
The patch is applied immediately after waking in the morning and removed before bedtime. The plaster should be imposed on a dry, clean, intact skin that does not contain hair, such as hips, upper limbs or chest. It is necessary to change the location of overlay every day: do not use the same area for two consecutive days.
After applying the patch, wash your hands to prevent eye irritation from possible ingress of nicotine.
Cancel combination therapy:
Отменять комбинированную терапию можно двумя способами.
Способ 1: в течение последующих 2 недель необходимо перейти с пластыря 25 мг/16 часов (1 этап) на пластырь 15 мг/16 часов (2 этап), а затем в течение последующих 2 недель на пластырь 10 мг/16 часов (3 этап), сохраняя при этом количество применяемых жевательных резинок «Никоретте®» с дозировкой 2 мг, как и при Начальной терапии. Далее постепенно снижают количество жевательных резинок до полной отмены в течение времени, которое необходимо человеку в зависимости от его потребностей, но не позднее, чем через 12 месяцев после начала применения комбинированной терапии.
Способ 2: заключается в полной отмене пластыря сразу после окончания этапа Начальной терапии. Далее постепенно снижают количество жевательных резинок «Никоретте®» с дозировкой 2 мг до полной отмены в течение времени, которое необходимо человеку в зависимости от его потребностей, но не позднее, чем через 12 месяцев после начала применения комбинированной терапии.
Подростки младше 18 лет
В возрасте до 18 лет жевательная резинка может применяться только по рекомендации врача!
Не превышайте указанную дозу!
Носите жевательную резинку с собой, чтобы воспользоваться ею, если Вам неожиданно захочется курить.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

Nicorette

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