Neo-l Penotran forte suppositories vaginas. 7 pc

$20.00

Neo-l Penotran forte suppositories vaginas. 7 pc

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SKU: 958033978

Description

Composition Active ingredient: 750 mg of metronidazole (micronized) and 200 mg of miconazole nitrate (micronised) Excipients 1550 mg Witepsol S 55 Description: Vaginal suppositories as a flat body with a rounded end, a white or nearly white. Product: Vaginal Suppositories. 7 suppositories in plastic blister PVC / PE. 1 with the blister package fingertips and instructions for use placed in a cardboard box. Contraindications: Known hypersensitivity to the active ingredients of the drug or its derivative, the first trimester of pregnancy, porphyria, epilepsy, severe liver problems, patients under the age of 18 years due to insufficient data on the use in this age group, virgins. Dosage 100 mg + 750 mg + 200 mg Indications – vaginal candidosis, – bacterial vaginosis – Trichomonas vaginitis – vaginitis caused by mixed infections. Interaction with other drugs Alcohol: interaction with metronidazole alcohol disulfiramopodobnye able to cause reaction. Oral anticoagulants: increased anticoagulant effect. Phenytoin: reduction in the blood concentration of metronidazole while increasing the concentration of phenytoin. Phenobarbital: reducing the concentration of metronidazole in blood. Disulfiram: possible side effects on the CNS (psychotic reactions). Cimetidine: may increase the concentration of metronidazole in the blood and increase the risk of neurological side effects. Lithium: there may be an increase of lithium toxicity. Astemizole and terfenadine: Metronidazole and miconazole inhibit the metabolism of these substances and increase their plasma concentrations. Overdose Data on overdose in humans with the use of intravaginal metronidazole no. However, when administered metronidazole in the vagina can be absorbed in sufficient quantities to cause systemic effects. Accidental ingestion of large amounts of a suppository if necessary, be made a gastric lavage. Improving the condition can then be achieved in subjects ingested 12 grams of metronidazole. No specific antidote exists. Recommended symptomatic and supportive therapy. Symptoms of metronidazole overdose include nausea, vomiting, abdominal pain, diarrhea, generalized itching, a metallic taste in the mouth, movement disorders (ataxia), dizziness, paresthesia, convulsions, peripheral neuropathy (including after prolonged use at high doses), leukopenia, urine darkening. Symptoms of overdose of miconazole nitrate were not identified. Pharmacological action Pharmacological group: Antimicrobial combined means (protivoprotozoynoe antimicrobial and antifungal agent +). Pharmacodynamics: Suppositories Neo-Forte Penotran® contain metronidazole, which has an antibacterial action and protivotrihomonadnyh and miconazole having antifungal effect. Metronidazole is an antibacterial agent and protivoprotozoynoe and is active against Gardnerella vaginalis and anaerobic bacteria, including anaerobic streptococci and Trichomonas vaginalis. Miconazole nitrate has a broad spectrum of action (especially active against pathogenic fungi including Candida albicans – the causative agent of thrush), is effective against Gram-positive bacteria. Pharmacokinetics: The bioavailability of metronidazole in intravaginal application of 20% as compared with oral administration. After vaginal administration of Neo-Forte Penotran® upon reaching equilibrium plasma metronidazole concentration was 1,6-7,2 mg / ml. Systemic absorption of miconazole nitrate in this method of administration is very low (about 1.4% of the dose) of miconazole nitrate was not detected in the plasma. Metronidazole is metabolized in the liver. Is active hydroxy metabolite. The half-life of metronidazole is 6-11 hours. Approximately 20% of the dose is excreted unchanged by the kidneys. Pregnancy and breast-feeding Suppositories Neo-Penotran® Forte can be used after the first trimester of pregnancy under medical supervision, provided that the anticipated benefits to the mother outweighs the potential risk to the fetus. At the time of treatment should stop breastfeeding because Metronidazole passes into breast milk. Breast feeding may be resumed after 24-48 hours after treatment. Conditions of supply of pharmacies by prescription. Side effects In rare cases, there may be an allergic reaction (skin rash) and side effects, such as abdominal pain, headache, vaginal irritation (burning, itching). Local reactions: miconazole nitrate may cause vaginal irritation (burning sensation, itching), as in the intravaginal application of any other antifungal agents based on imidazole derivatives (2-6%). If severe irritation, treatment should be discontinued. Systemic side effects occur very rarely, since for vaginal metronidazole absorption level in plasma is very low. By the side effects associated with systemic absorption of metronidazole include: allergic reaction (rare), leukopenia, ataxia, mental changes (anxiety, mood lability), convulsion, seldom diarrhea, constipation, dizziness, headache, loss of appetite, nausea, vomiting, pain or cramps, changes in taste (rare), dry mouth, metallic taste or unpleasant, fatigue. Cautions Preclinical data indicate that there is no specific risk to humans, based on the results of standard safety research, pharmacology, toxicity of repeated doses, genotoxicity, carcinogenic potential, toxicity to the reproductive system. It is necessary to avoid taking alcohol during treatment and for at least 24-48 hours after completion of disulfiramopodobnyh because of possible reactions. Care should be taken when using the suppository simultaneously with contraceptive diaphragms and condoms because of the possible damage to the rubber suppository base. Patients with a diagnosis of “Trichomonas vaginitis” should be simultaneous treatment of sexual partners. Do not ingest or apply a different way! Laboratory tests to change the results in determining the level of liver enzymes, glucose (hexokinase method), theophylline and procainamide in the blood. Effects on ability to drive and use machinery Suppositories Neo-Forte Penotran® not affect the ability to drive and use machines. Storage conditions at a temperature no higher than 25 ° C. Do not store in the refrigerator. Keep out of the reach of children. Dosing and dose Intravaginal. 1 vaginal suppository injected deep into the vagina for 7 days for the night. In recurrent vaginitis vaginitis or resistant to other forms of treatment, Neo-Penotran® Forte should be used within 14 days. Suppositories should be inserted deep into the vagina using a disposable fingertips, which are attached in the package. Elderly patients (over 65 years): the same recommendations as for younger patients. Info appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist Do not store in the refrigerator. Keep out of the reach of children. Dosing and dose Intravaginal. 1 vaginal suppository injected deep into the vagina for 7 days for the night. In recurrent vaginitis vaginitis or resistant to other forms of treatment, Neo-Penotran® Forte should be used within 14 days. Suppositories should be inserted deep into the vagina using a disposable fingertips, which are attached in the package. Elderly patients (over 65 years): the same recommendations as for younger patients. Info appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist Do not store in the refrigerator. Keep out of the reach of children. Dosing and dose Intravaginal. 1 vaginal suppository injected deep into the vagina for 7 days for the night. In recurrent vaginitis vaginitis or resistant to other forms of treatment, Neo-Penotran® Forte should be used within 14 days. Suppositories should be inserted deep into the vagina using a disposable fingertips, which are attached in the package. Elderly patients (over 65 years): the same recommendations as for younger patients. Info appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist 1 vaginal suppository injected deep into the vagina for 7 days for the night. In recurrent vaginitis vaginitis or resistant to other forms of treatment, Neo-Penotran® Forte should be used within 14 days. Suppositories should be inserted deep into the vagina using a disposable fingertips, which are attached in the package. Elderly patients (over 65 years): the same recommendations as for younger patients. Info appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist 1 vaginal suppository injected deep into the vagina for 7 days for the night. In recurrent vaginitis vaginitis or resistant to other forms of treatment, Neo-Penotran® Forte should be used within 14 days. Suppositories should be inserted deep into the vagina using a disposable fingertips, which are attached in the package. Elderly patients (over 65 years): the same recommendations as for younger patients. Info appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist Suppositories should be inserted deep into the vagina using a disposable fingertips, which are attached in the package. Elderly patients (over 65 years): the same recommendations as for younger patients. Info appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist Suppositories should be inserted deep into the vagina using a disposable fingertips, which are attached in the package. Elderly patients (over 65 years): the same recommendations as for younger patients. Info appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

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Weight0.100 kg
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