Naiz gel 50g 1%


Naiz gel 50g 1%


SKU: 0999666515 Categories: , , Tags: ,


Active substance:
1 g of gel contains 10 mg of nimesulide.
N-methyl-2-pyrrolidone 250 mg Propylene Glycol 100 mg, 315.5 mg macrogol, isopropanol, 100 mg, 200 mg purified water, carbomer-940 20 mg, butylhydroxyanisole 0.2 mg, 0.1 mg thiomersal, potassium dihydrogen 0 2 mg, flavor (Narcissus-938) 4 mg.
Transparent gel pale yellow or yellow, free from extraneous particles.
Product form:
Gel for external application of 1%. 50 g of laminated aluminum tube, provided with a membrane to control the first opening. The tube is packed in a cardboard box with instructions for use.
Hypersensitivity to the drug component and nimesulide; erosive-ulcerous lesions of the gastrointestinal tract in the acute stage, bleeding from the gastrointestinal tract, dermatitis, epidermal injury and infection of the skin in the application; severe renal (creatinine clearance less than 30 mL / min.) or hepatic failure, indication of a history of bronchospasm on the phenomena associated with the use of aspirin or other NSAIDs, pregnancy and lactation, children age 7 years.
Liver failure; renal failure; severe heart failure; arterial hypertension; type 2 diabetes; elderly and children’s age.
1 %
Local symptomatic treatment of inflammatory and degenerative diseases of the musculoskeletal system (joint syndrome in exacerbation of gout, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, osteoarthritis, osteochondrosis with radicular syndrome, sciatica, inflammation of ligaments, tendons, bursitis, sciatica, lumbago). Muscular pain of rheumatic and rheumatic origin. Post-traumatic inflammation of soft tissue and musculoskeletal system (damages and torn ligaments, bruises).
Interaction with other drugs
It is possible pharmacokinetic interactions with drugs competing for the connection to plasma proteins. Caution must be exercised while the use Nayz® with digoxin, phenytoin, lithium preparations, diuretics, cyclosporine, methotrexate, other NSAIDs, antihypertensive and antidiabetic agents. Before use, the gel should consult with your doctor if you are using these funds or are under a doctor’s supervision.
The cases of drug overdose not described. However, when applied to large quantities of the gel (in excess of 50 g) to extensive areas of skin is not excluded overdose development. There is no specific antidote. Should consult a doctor.
pharmachologic effect
Pharmacological group:
Nonsteroidal anti-inflammatory drug (NSAID).
Nayz® gel is a nonsteroidal anti-inflammatory drug (NSAID) of the new generation of the class of sulfonamides. It has a local analgesic and anti-inflammatory effect.
Nimesulide – selective competitive reversible inhibitor of cyclooxygenase type II (prostaglandin endoperoxide-H2r synthetase). It reduces the concentration of the short-prostaglandin H2 substrate kinin-stimulated synthesis of prostaglandin E2, in inflammation and ascending paths of pain impulses in the spinal cord. Reducing the concentration of prostaglandin E2 (a mediator of inflammation and pain) reduces activation type EP prostanoid receptors, which manifests anti-inflammatory and analgesic effects.
When applied topically cause weakening or disappearance of pain at the site of gel application, including joint pain at rest and during motion, reduces morning stiffness and swelling of joints. Increases the range of motion.
When applying a gel concentration of active substance in the systemic circulation is very low. The maximum concentration observed after a single application of the end of the first day, its value is more than 300 times lower than that for the oral dosage forms of nimesulide. Traces main metabolite nimesulide – 4- hydroxynimesulide blood is detected.
Conditions of supply of pharmacies
Without recipe.
side effects
Local reactions: itching, rash, peeling, transient changes in skin color (which does not require discontinuation of the drug).
If there are any adverse reactions should stop using the product and consult a physician.
When applying the gel to extensive areas of the skin with prolonged use or not possible development of adverse systemic reactions, heartburn, nausea, vomiting, diarrhea, gastralgia, ulceration of mucosa of the gastrointestinal tract, increased activity “liver” transaminase; headache, dizziness; fluid retention, hematuria; allergic reactions (anaphylaxis, skin rash); thrombocytopenia, leukopenia, anemia, agranulocytosis, prolongation of bleeding time.
special instructions
The drug is recommended to be applied only to intact skin while avoiding contact with open wounds. Avoid contact with the gel in the eye and other mucous membranes. Do not use the gel under airtight dressings. After application of the gel Wash hands with soap. Tightly close the tube after use of the gel.
Storage conditions
In a dry, dark place at a temperature not higher than 25 ° C.
Do not freeze.
Keep out of the reach of children!.
Dosing and Administration
Outwardly. Before applying the gel to wash and dry the surface of the skin. Apply a thin uniform layer of the gel column of length about 3 cm to the area of ​​maximum pain, without rubbing, 3-4 times a day. The amount of gel and the frequency of its application (no more than 4 times a day) may vary depending on the area to be treated and the patient’s response.
Do not apply the gel more than 10 days without consulting a doctor.
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg


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