Mucosolvan rhino nasal spray 82mkg / 10ml dose eucalyptus / menthol / camphor

Description

Composition
Active substance:
1 dose spray contains: tramazolina hydrochloride monohydrate, based on tramazolina hydrochloride 82 mg.
Excipients:
Citric acid monohydrate 270 g, sodium hydroxide 154 .mu.g, 14 .mu.g benzalhoniya chloride, hypromellose (Hydroxy propyl cellulose methylation l) 35 g, Povidone 2101 g, 85% glycerol, 700 ug, magnesium sulfate heptahydrate 49 g. magnesium chloride hexahydrate, 35 g calcium chloride dihydrate 11 g, 1 g of sodium hydrogen carbonate, sodium chloride, 183 micrograms. cineol (eucalyptus l) 7 g, L-menthol (levomenthol) 14 .mu.g, 14 .mu.g racemic camphor, purified water 66358 g.
Description:
The clear, pale yellow solution with eucalyptus odor.
Product form:
Nasal spray dosage 82 .mu.g / dose.
10 ml vial of brown glass equipped with a dosing device and a nasal adapter with a protective cap. Bottle with instructions for use placed in a cardboard box.
Contraindications
Hypersensitivity to tramazolina hydrochloride or benzalkonium hydrochloride, as well as to other components of an angle-closure glaucoma, atrophic rhinitis, surgery on the skull made through the nasal cavity, and the history, children under 6 years.
Carefully
Patients with hypertension, heart disease, hyperthyroidism, prostatic hypertrophy, pheochromocytoma. porphyria should apply Lasolvan Reno only on doctor’s advice in connection with the presence of the potential risk of systemic absorption of the drug.
Caution must be exercised when receiving MAO inhibitors, tricyclic antidepressants, vasopressor drugs and antihypertensive drugs.
Dosage
82 ug / dose
Indications
Swelling of the nasal mucosa, nasal congestion, caused by acute respiratory infections and / or poplinozom (rhinitis, hay fever).
When sinusitis and otitis media (evstaheite). to facilitate the outflow of the contents of the paranasal sinuses, on doctor’s advice.
Interaction with other drugs
Some antidepressants (MAO inhibitors and tricyclic antidepressants) and vasoconstrictor drugs with concomitant administration may cause blood pressure.
Combined reception with tricyclic antidepressants can lead to arrhythmias.
Simultaneous treatment with antihypertensive agents (especially those that affect the sympathetic nervous system) can lead to different cardiovascular effects.
Overdose
Following the increase in blood pressure and tachycardia may (especially in children), drop in blood pressure, shock development, reflex bradycardia, low body temperature.
By analogy with other alpha-sympathomimetics, and the clinical picture of intoxication can be indistinct, as the stimulation phase and central nervous system depression and cardiovascular systems can replace each other.
Especially in children intoxication leads to effects on the central nervous system with the development of seizures, and coma, bradycardia. respiratory depression. CNS stimulation symptoms are anxiety, agitation, hallucinations, and seizures The symptoms of CNS depression include decreased body temperature, lethargy, drowsiness and coma.
In addition, it is possible to develop the following symptoms: mydriasis, miosis, sweating, fever, pallor, cyanosis of the lips, a violation of the cardiovascular system (including heart failure), respiratory failure (including respiratory failure, respiratory failure); psychological disorders.
Treatment
In the case of nasal overdose immediately wash or clean the nose. You may need symptomatic treatment.
pharmachologic effect
Pharmacological group:
Decongestant agent (alpha-agonists).
Pharmacodynamics:
Active substance formulation Mucosolvan Reno – tramazolina hydrochloride, alpha-2-agonists to cause vasoconstriction. When applied to the mucous membranes of the nose due to the vasoconstrictive action of the drug reduces puffiness. As a result, the permeability of the nasal passages is restored quickly, nasal breathing is facilitated by long time.
Effect of the drug begins during the first 5 minutes and lasts 8-10 hours.
Pharmacokinetics:
Pharmacokinetic studies in humans have not been conducted tramazolina pharmacokinetics was studied in rats, rabbits and monkeys have shown that after application of the drug orally or intranasally absorbed 50-80% of the administered dose. Tramazolin and its metabolites are distributed in all internal organs, with the highest concentration found in the liver constancy. Following oral or topical application major metabolites are determined in urine. The terminal half-life of from 5 to 7 hours.
Pregnancy and breast-feeding
Long experience with shows that Lasolvan Reno has no adverse effect on pregnancy. Safety of the drug during lactation has not been confirmed. Lasolvan Reno should not be used during the first trimester of pregnancy. In the later stages of pregnancy and during breastfeeding is allowed to use the drug only after consulting your doctor.
Conditions of supply of pharmacies
Without recipe.
side effects
Disorders of the nervous system
Rare (> 0.01% and
Infrequently (> 0.1% and
The frequency is not installed *: drowsiness, sedation
mental disorders
Infrequently (> 0.1% and
The frequency is not installed *: hallucinations, insomnia
Violations of the cardiovascular system
Infrequently (> 0.1% and
The frequency is not installed *: arrhythmia, tachycardia, increased blood pressure
Violations by the respiratory organs of the chest and mediastinum
Frequent (> 1% and
Infrequently (> 0.1% and
Rarely (> 0.01% and
Disorders of the gastrointestinal tract
Infrequently (> 0.1% and
Violations by the immune system
The frequency is not installed *: hypersensitivity
Violations by the kosh and subcutaneous tissue **
The frequency is not installed *: rash, itching, swelling of the skin
General and local disturbances
The frequency is not installed *: ** mucosal edema, fatigue * Adverse events, whose connection with the preparation was regarded as a possible, registered with the broad application of the drug. The frequency of these rare events is difficult to assess. ** as the hypersensitivity symptoms.
special instructions
If after 7 days of administration of the drug is observed positive dynamics of symptoms, you should consult your doctor to decide on the discontinuation or continuation of treatment. Prolonged use of nasal vasoconstrictor drugs can lead to the development of chronic inflammation and nasal congestion, as well as to atrophy of nasal mucosa. Avoid getting product in eyes.
Effect on the driving ability and mechanical equipment
Studies on the effect of the drug on the ability to drive and use machinery have not been conducted. However, the drug can such undesirable effects such as hallucination, drowsiness, sedation, dizziness and fatigue. Therefore, caution should be exercised when driving and machinery.
When the above side effects to avoid execution of such potentially dangerous tasks such as driving and machinery.
Storage conditions
At a temperature of not higher than 25 C.
Keep out of the reach of children.
Dosing and Administration
Adults and children over 6 years: one injection into each nasal passage. Up to 4 injections in each nostril per day.
You should not use the drug for more than 5 – 7 days without a doctor’s prescription
Instructions for using the bottle with a dosing device:
nasal passages should be cleaned prior to injection. Remove the protective cap 1. 2. Before first use, you must make several injections into the air until stable aerosol cloud.
After that, the dispensing device is ready for use. 3. Hold your head up, enter a tip in the nasal passage and produce one injection
Repeat procedure for the other nasal passage. After extraction of the tip to produce a normal breath through the nose. 4. Place a protective cap.
It is recommended to clean the tip after each use.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist