Monural granules for susp. 3g sachet 1 pc

Description

Composition
Active substance:
1 package contains: active substance – fosfomycin trometamol 3.754 g or 5.631 g (equivalent to 2.0 g or 3.0 g of fosfomycin) ;.
Excipients:
Flavoring mandarin, orange flavor, saccharin, sucrose.
Description:
Granules white odor tangerine.
Product form:
Granules for preparation for the oral solution of 2 g and 3 g to 6 g and 8 g of the formulation was put in bags of a 4-layer laminated foil (paper-polyethylene-aluminum-polyethylene). 1 or 2 packets are placed in a cardboard box, together with instructions for use.
Contraindications
Individual hypersensitivity to the FT, severe renal insufficiency.
Dosage
3 g
Indications
Acute bacterial cystitis, acute episodes of recurrent bacterial cystitis; bacterial non-specific urethritis; massive asymptomatic bacteriuria in pregnant women; postoperative urinary tract infection; prevention of urinary tract infection during surgery and transurethral diagnostic tests.
Overdose
Symptoms of overdose include diarrhea. In the event of persistent diarrhea is recommended symptomatic treatment.
The risk of overdose is minimum, since Monural available in multiples of 1 or 2 of the package. In the case of an overdose of recommended intake of liquid inside to increase diuresis.
Interaction with other drugs
Avoid simultaneous reception with metoclopramide, as this may lead to a reduction monural concentration in serum and urine.
pharmachologic effect
Pharmacological group:
Antibiotic.
Pharmacodynamics:
Active substance monural – fosfomycin trometamol – a broad spectrum antibiotic, a derivative of phosphonic acid.
Monural has a bactericidal action. The mechanism of action is associated with the suppression of the first stage of bacterial cell wall synthesis. As a structural analog fosfoenola pyruvate enters the competitive interaction with the enzyme N-acetyl-glucosamine-3-o-enolpiruvil-transferase, whereby there is a specific, selective, and irreversible inhibition of this enzyme, which ensures that no cross-resistance with other classes of antibiotics and the ability to synergy with other antibiotics (in vitro note synergism with amoxicillin, cephalexin, pipemidinovoy acid). Fosfomycin trometamol spectrum antibacterial in vitro action includes the most common gram-positive (Enterococcus spp., Enterococcus faecalis, Staphylococcus aureus, Staphylococcus saprophyt., Staphylococcus spp.) And gram negative (E. coli, Citrobacter spp., Enterobacter spp., Klebsiella spp., Klebsiella pneumoniae, Morganella morganii, Proteus mirabilis, Pseudomonas spp., Serratia spp.) pathogens. In vitro fosfomycin trometamol reduces the number of bacteria on the adhesion of the epithelium of the urinary tract.
Pharmacokinetics:
Absorption: Monural rapidly absorbed from the gastrointestinal tract after oral administration.
In the body, and dissociates into fosfomycin trometamol. Last not have antibacterial properties. Bioavailability after a single ingestion dose of 3 g is from 34 to 65%. Maximum plasma concentration is observed after 2-2.5 hours after oral administration and is 22-32 mg / l. Plasma half-life equal to 4 hours.
Distribution: Monural not bound to plasma proteins, not metabolized, mainly in the urine is accumulated. On oral administration of a single dose of 3 g in the urine, a high concentration (from 1053 to 4415 mg / l) for 99% bactericide for most common causative agents of urinary tract infections. Minimum ingibiruyushaya monural concentrations for these agents is 128 mg / l. It is supported in the urine for 24-48 hours, which implies a single-dose treatment. Monural concentration in urine above a minimum inhibitory concentration for E. coli stored at least for 80 hours.
Excretion: Monural 90% excreted by the kidneys in unchanged form to the creation of high concentrations in the urine. About 10% of the dose is displayed through the intestine intact.
Pregnancy and breast-feeding
In pregnancy, the drug is prescribed only if the potential benefit to the mother outweighs the potential risk to the fetus. If necessary, the appointment during lactation should stop breastfeeding during treatment.
Conditions of supply of pharmacies
On prescription.
side effects
There are disorders of the gastrointestinal (nausea, heartburn, diarrhea), skin rashes, allergic reactions.
special instructions
Simultaneous reception write slows absorption monural – you need to use the drug 2 hours before or after a meal.
Diabetics should be borne in mind that the package 1 monural with a dosage of 2 g or 3 g of fosfomycin contained 2,100 g or 2,213 g of sucrose, respectively.
Storage conditions
Store at a temperature not higher than 30 ° C. Keep out of the reach of children.
Dosing and Administration
Inside.
The granules dissolved in 1/3 cup water. Monural applied once daily by mouth on an empty stomach 2 hours before or after meals, preferably before bedtime, after emptying the bladder. Adults appoint one package (3 g), 1 time per day.
In order to prevent urinary tract infection during surgery, transurethral diagnostic procedures take Monural twice at the doses indicated above: for 3 hours before surgery and 24 hours after the intervention.
Children from 5 years to 18 years, administered in a daily dose of 2 g 1 time per day.
The course of treatment is 1 day.
In more severe cases (elderly patients, recurrent infections) take another 1 package after 24 hours.
In renal failure and reduce the dose lengthen intervals between administrations.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist