Milgamma kompozitum tab n / 100mg of 30 pcs

$16.53

Milgamma kompozitum tab n / 100mg of 30 pcs

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Description

Composition
Active substance:
100.0 mg benfotiamine, pyridoxine hydrochloride, 100.0 mg.
Excipients:
Microcrystalline Cellulose – 222.0 mg, povidone (K value = 30) – 8.0 mg, omega-3 triglycerides (20%) – 5.0 mg Colloidal silicon dioxide – 7.0 mg Sodium carmellose – 3.0 mg talc – 5.0 mg;
shell composition: shellac – 3.0 mg, sucrose – 92.399 mg Calcium carbonate – 91.675 mg talc – 55.130 mg, acacia gum – 14.144 mg maize starch – 10.230 mg titanium dioxide – 14.362 mg colloidal silica – 6,138 mg , povidone (K value = 30) – 7.865 mg macrogol 6000 – 2.023 mg, 85% glycerol – 2.865 mg of polysorbate-80 – 0.169 mg, mountain wax glycol – 0.120 mg.
Description:
Round, biconvex, film-coated tablets of white color.
Product form:
Coated tablets.
15 coated tablets in blisters (blister) made of PVC film and aluminum foil.
2 or 4 blister (15 coated tablets each) together with instructions for use in a cardboard box.
Contraindications
Increased sensitivity to individual thiamine, benfotiamine, pyridoxine or other components of the formulation.
During pregnancy and breastfeeding. (See. Section “Pregnancy and lactation”).
Children age due to lack of data.
Each tablet contains 92.4 mg of sucrose. Therefore, the drug should not be applied to persons with congenital fructose intolerance, malabsorption of glucose and galactose or glucose – izomaltaznym deficit. • If you have one of these diseases, before taking this medication, you should consult with your doctor.
Dosage
100 mg
Indications
Neurological disorders with confirmed deficiency of vitamins B1 and B6.
Interaction with other drugs
At therapeutic doses of pyridoxine (vitamin B6) may reduce the effect of levodopa. The simultaneous use of antagonists of pyridoxine (e.g., hydralazine, isoniazid, penicillamine, cycloserine), alcohol and estrogensoderjath prolonged use of oral contraceptives may cause vitamin B6 deficiency in the body.
When taken together with the marked deactivation fluorouracil thiamine (vitamin B1), since the fluorouracil competitively inhibits the phosphorylation of thiamine to thiamine diphosphate.
Overdose
Overdose symptoms.
Given the wide therapeutic index, overdosing benfotiamine ingestion is unlikely.
High doses for a short period of time pyridoxine (vitamin B6) (in a dose of 1 g per day) can cause a momentary appearance of the neurotoxic effects. In applying the drug at a dose of 100 mg to knock over 6 months may also develop neuropathy.
Overdose is usually manifested in the form of sensory polyneuropathy, which can be accompanied by ataxia. The drug in very high doses may cause convulsions. On newborns and infants the drug may have a strong sedative effect, cause hypotension and respiratory disorders (dyspnea, sleep apnea).
Treatment of overdose. When receiving pyridoxine dose exceeding 150 mg / kg of body weight are recommended to induce vomiting and take activated charcoal. Provocation emesis is most effective during the first 30 minutes after ingestion. It may be required to take emergency measures.
pharmachologic effect
Pharmacological group:
Vitamins.
Pharmacodynamics:
Benfotiamine, a fat-soluble derivative of thiamine (vitamin B1), in an organism is phosphorylated to the active coenzymes thiamine triphosphate and thiamine diphosphate. Thiamine diphosphate is a coenzyme pyruvate decarboxylase, 2-oksiglyutaratdegidrogenazy and transketolase, participating thus in the pentose phosphate cycle, glucose oxidation (transferring aldehyde group).
Phosphorylated form of pyridoxine (vitamin B6) – pyridoxal – is a coenzyme of a number of enzymes that affect all stages of non-oxidative metabolism of amino acids.
Pyridoxal phosphate is involved in the decarboxylation of amino acids, and hence in the formation of physiologically active amines (e.g., epinephrine, serotonin, dopamine, tyramine). Participating in the amino acid transamination, pyridoxal phosphate is involved in the anabolic and catabolic processes (e.g., as a coenzyme transaminases such as glutamate-oksalotsetat- transaminase, glutamate pyruvate transaminase, gamma-aminobutyric acid (GABA), alpha ketoglutarat- transaminase), and in various decomposition reactions and synthesis of amino acids. Vitamin B6 is involved in 4 different stages of tryptophan metabolism.
Pharmacokinetics:
When ingestion of a large part of benfotiamine is absorbed in the duodenum, less – in the upper and middle sections of the small intestine. Benfotiamine absorbed due to active resorption at concentrations of 2 micromolar. As a fat-soluble derivative of thiamine (vitamin B1), benfotiamine absorbed faster and more completely than soluble thiamine hydrochloride. In the intestine, benfotiamine is converted into S-benzoiltiamin resulting dephosphorylation phosphatases. S-benzoiltiamin fat soluble, it has a high penetrating power and absorbed mainly without becoming thiamine. Due to enzymatic Debenzoylation formed after absorption thiamine and biologically active coenzymes thiamine triphosphate and thiamine diphosphate. Particularly high levels of coenzymes data observed in the blood, liver, kidney, muscle and brain.
Pyridoxine (vitamin B6) and derivatives thereof are absorbed mainly in the upper parts of the gastrointestinal tract during passive diffusion. The serum pyridoxal and pyridoxal bound to albumin. Before penetration through the cell membrane pyridoxal phosphate, is bound to albumin, alkaline phosphatase hydrolyzes to form pyridoxal.
Both vitamin derived predominantly in the urine. Approximately 50% of thiamine excreted unchanged form or in the form of sulphate. The remaining part is composed of several metabolites, including isolated tiaminovuyu acid metiltiazo-acetic acid and Pyramin. The average half-life (t 1/2) of blood benfotiamine is 3.6 hours. The half-life of pyridoxine ingestion of about 2-5 hours. The biological half-life of thiamine, and pyridoxine is about 2 weeks.
Pregnancy and breast-feeding
Use of the drug is contraindicated during pregnancy and breastfeeding. (See. See “Contraindications”).
Conditions of supply of pharmacies
Without a prescription.
side effects
The frequency of side effects is allocated in the order often (10% of cases), often (in 1% – 10% of cases), rare (0.1% – 1%), rare (0.01% – 0 , 1%), very rarely (less than 0.01% of cases), and side effects are often unknown.
Immune system:
Very rarely hypersensitivity reaction (skin reactions, itching, hives, skin rash, difficulty breathing, angioneurotic edema, anaphylactic shock). In some cases – headache.
From the nervous system:
Frequency not known (single spontaneous reports): peripheral sensory neuropathy at the long-term use (more than 6 months).
On the part of the gastrointestinal tract:
Very rare: nausea.
Skin and subcutaneous tissue:
Frequency not known (single spontaneous reports): acne, increased sweating.
Cardio-vascular system:
Frequency not known (single spontaneous reports): tachycardia.
If any of these instructions side effects are compounded, or if you notice any other side effects not mentioned in the instructions, tell your doctor.
special instructions
In applying the drug in doses of 100 mg per day for over 6 months may develop sensory peripheral neuropathy.
Ability to influence the reaction rate when driving or operating other machinery. There are no warnings regarding the use of the drug by drivers of vehicles and persons working with potentially dangerous machinery.
Storage conditions
At temperatures above 25 ° C.
Keep out of the reach of children.
Dosing and Administration
Inside.
The tablet should drink plenty of fluids.
Unless otherwise prescribed by your doctor, an adult should take 1 tablet per day.
In acute cases, after consulting a doctor dose may be increased to 1 tablet, 3 times a day.
After 4 weeks of treatment, the physician must decide whether to continue taking the drug in an increased dose and consider the possibility of reducing elevated levels of vitamins B6 and B1 to 1 tablet per day. If possible, the dose should be reduced to 1 tablet per day to reduce the risk of developing neuropathy associated with the use of vitamin B6.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

VOERVAG

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