Mildronat caps. 250mg 40 pieces


Mildronat caps. 250mg 40 pieces



Active substance:
meldonium dihydrate 250 mg
potato starch, colloidal silicon dioxide, calcium stearate; capsule (body and cap) – titanium dioxide (E 171), gelatin.
Hard gelatin capsules № 1 of white color. Content – a white crystalline powder with a faint odor. Hygroscopic powder.
Product form:
Capsules 250 mg.
10 capsules in blisters of PVC film or polyvinyl chloride film coated with polyvinylidene chloride and aluminum foil. 4 blisters together with instructions for use placed in a cardboard box.
Hypersensitivity to meldonium or any other component of the drug.
Increased intracranial pressure (in violation of the venous outflow, intracranial tumors).
Pregnancy and breast-feeding.
Age 18 years (safety is not confirmed).
Precautions: liver and / or kidney.
250 mg
Impaired performance, mental and physical overload.
Interaction with other drugs
Meldonium may be used simultaneously with long-acting nitrates, and other antianginal drugs, cardiac glycosides and diuretics. It can also be combined with anticoagulants, antiplatelet agents, antiarrhythmic drugs and other drugs that improve the microcirculation.
Meldonium may exacerbate the effects of nitroglycerin, nifedipine, beta-blockers, other antihypertensive agents and peripheral vasodilators.
Simultaneous use of the drug with other drugs meldonium is not allowed because it may increase the risk of adverse reactions.
About meldonium cases of overdose have been reported. The drug has low toxicity and does not cause severe adverse reactions.
Symptoms: decrease in blood pressure accompanied by headache, palpitations, dizziness and general weakness.
Treatment: symptomatic.
In severe overdosing is necessary to monitor liver and kidney function.
pharmachologic effect
Pharmacological group:
Metabolic means.
Meldonium is a precursor of carnitine, a structural analog of gamma-butyrobetaine (GBB), a substance that is found in every cell of the human body.
In high load conditions meldonium restores the balance between the delivery and demand of cells in oxygen, eliminates the accumulation of toxic products of metabolism in the cells, protecting them from damage; also exerts a tonic effect. As a result of its use increases the body’s resistance to stress and ability to quickly restore energy reserves.
The drug has a stimulating effect on the central nervous system (CNS) – increase of motor activity and physical endurance. Because of these properties Mildronate® use including to enhance physical and mental performance.
After oral administration, the drug is rapidly absorbed, bioavailability – 78%. The maximum concentration (Cmax) in plasma is achieved within 1-2 hours after ingestion. It is metabolized in the body mainly in the liver with the formation of two major metabolites are excreted by the kidneys. The half-life (T1 / 2) when administered depends on the dose of 3-6 hours.
Pregnancy and breast-feeding
Health and Safety in pregnant women has not been studied, therefore, in order to avoid possible adverse effects on the fetus, use of the drug in pregnant women is contraindicated.
Excretion of milk and the effect on the health of the newborn have not been studied, therefore, if necessary, the drug should stop breastfeeding.
Conditions of supply of pharmacies
Without recipe.
side effects
Meldonium usually well tolerated. However, in susceptible patients, and also in cases exceeding the recommended dose may cause adverse reactions.
Adverse drug reactions are grouped by organ system-classes according to the following gradation frequency: very often (> 1/10), often (> 1/100 and
special instructions
Patients with chronic liver diseases and kidney caution during prolonged application of the drug. If necessary, long-term (more than one month) of the drug should consult a specialist.
Effect on the ability to drive mechanisms and
No information on the adverse effects on driving ability and the performance of potentially hazardous activities that require high concentration and psychomotor speed reactions.
Storage conditions
Stored in a dry place at a temperature no higher than 25 degrees.
Keep out of the reach of children.
Dosing and Administration
The daily dose for adults is 500 mg (2 capsules). All morning dose used in one portion or dividing it into 2 doses.
The course of treatment – 10-14 days.
If necessary, repeat the treatment after 2-3 weeks.
In connection with a possible stimulating effect of the drugs recommended in the first half of the day.
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg


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