Mezim PRO 20 tab (Mezym PRO)

Description

Dosage form

Pink, flat-cylindrical coated tablets with almost plane-parallel surfaces and beveled edges, brown blotches are possible on the fracture.

Compound

Composition for one tablet
Core
Active substance:
Pancreatin * 100,000 -138,889 mg with minimum activity:
lipase 10,000 units
amylase 7500 U
protease 375 U
Excipients: lactose monohydrate, microcrystalline cellulose (type 12), colloidal silicon dioxide, crospovidone, magnesium stearate;
Sheath: hypromellose (~ 5 mPa s), methacrylic acid and ethyl acrylate copolymer (1: 1) dispersion 30% (dry weight), triethyl citrate, titanium dioxide (E 171), talc, simethicone emulsion 30% (dry weight), macrogol 6000, sodium carmellose, polysorbate 80, azorubin varnish (E 122), sodium hydroxide.
* obtained from pork pancreas

Special conditions

In acute pancreatitis or exacerbation of chronic pancreatitis (at the stage of exacerbation attenuation), during a restorative diet, it is advisable to prescribe Mezim® Pro against the background of existing or remaining in the future pancreatic insufficiency.
The drug Mezim® Pro, taking into account the solid indivisible dosage form, is contraindicated in children under 3 years of age.
The effect of the drug on the ability to drive vehicles and mechanisms
Mezim® Pro does not affect the speed of psychomotor reactions and the ability to perceive or assess the situation.

Drug interactions

When taking drugs containing pancreatin, it is possible to reduce the absorption of folic acid. The effect of hypoglycemic drugs (acarbose, miglitol) may decrease when taken simultaneously with pancreatin.
With the simultaneous use of pancreatin with iron preparations, it is possible to reduce the absorption of the latter. The simultaneous use of antacids containing calcium carbonate and / or magnesium hydroxide may lead to a decrease in the effectiveness of the drug.

Pharmacodynamics

An enzyme preparation that improves digestion. Pancreatin is a powder from pork pancreas, which, along with exocrine pancreatic enzymes – lipase, amylase, protease, trypsin and chymotrypsin, contains other enzymes.
The pancreatic enzymes included in the preparation facilitate the breakdown of proteins, fats and carbohydrates, which leads to their more complete absorption in the small intestine. Trypsin suppresses the stimulated secretion of the pancreas, providing an analgesic effect. The maximum enzymatic activity of the drug is observed 30-45 minutes after oral administration.

Pharmacokinetics

Mezim® Pro tablets are coated with an acid-resistant coating that does not dissolve under the action of gastric hydrochloric acid and thus protects the enzymes contained in the preparation from inactivation. The dissolution of the shell and the release of enzymes occurs at a pH value close to neutral or slightly alkaline.

Indications

• replacement therapy for exocrine pancreatic insufficiency (including chronic pancreatitis, cystic fibrosis);
• chronic inflammatory-dystrophic diseases of the stomach, intestines, liver, gallbladder;
• conditions after resection or irradiation of the gastrointestinal tract, accompanied by impaired digestion, flatulence, diarrhea (as part of combination therapy);
• functional gastrointestinal tract disorder (with intestinal infectious diseases, irritable bowel syndrome, etc.);
• to improve the digestion of food in patients with normal gastrointestinal tract function in case of inaccuracies in nutrition;
• preparation for X-ray and ultrasound examinations of the abdominal organs.

Contraindications

• acute pancreatitis;
• exacerbation of chronic pancreatitis;
• hypersensitivity to pancreatin or other components of the drug;
• hereditary galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome;
• children under 3 years of age (indivisible dosage form).
Application during pregnancy and during breastfeeding
Due to the lack of sufficient data on the use of pancreatic enzymes in humans during pregnancy and lactation, the use of Mezim® Pro is possible only if the expected benefit to the mother outweighs the possible risk to the fetus or child.
Method of administration and dosage
The dose of Mezim® Pro is set individually, depending on the severity of the disease and the composition of the food.
Unless otherwise indicated, the average single dose for adults is 2-4 tablets of Mezim® Pro per meal. It is recommended to take half or a third of a single dose at the beginning of a meal, and the rest during it. The drug is taken orally without chewing and drinking a sufficient amount of liquid.