Metronidazole suppositories vaginas. 500mg 10 pieces aveksima

$94.00

Metronidazole suppositories vaginas. 500mg 10 pieces aveksima

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Description

Composition Active substance 1 suppository contains: Metronidazole 500 mg. Excipients: semi-synthetic glycerides (Suppotsir AM) – sufficient quantity to produce 2000 mg of suppository mass. Description: Suppositories cylindrical-shaped, white to white with a yellowish tinge. On the cut tolerance of air core or funnel-shaped depressions. Product: 500 mg vaginal suppositories. 5 suppositories in blisters. 2 blisters together with instructions for medical use in a pile of cardboard. Hypersensitivity to metronidazole or to other nitroimidazole derivative; blood diseases, leukopenia (including in history); incoordination, central nervous system diseases (including epilepsy); hepatic failure (in the appointment of high doses); pregnancy (I trimester), lactation, children under 18 years. Precautions: pregnancy (II – III trimesters). Dosage 500 mg Indications Local treatment of Trichomonas vaginitis, bacterial vaginosis and nonspecific vaginitis caused by microorganisms susceptible to metronidazole. Interaction with other drugs In an application with indirect anticoagulants (eg, warfarin) metronidazole enhances their action which leads to an increase in prothrombin time. It is not recommended to combine with the non-depolarizing muscle relaxants (e.g. vecuronium bromide). Similarly, disulfiram, causes intolerance of ethanol. Concomitant use of metronidazole with disulfiram may lead to the development of a variety of neurological syndromes (depression of consciousness, the development of mental disorders). Under the influence of barbiturates (e.g., phenobarbital) decreases the effectiveness of metronidazole by accelerating its inactivation in the liver. In an application with cimetidine may increase metronidazole serum and increases the risk of adverse reactions. Together with the admission lithium drugs may increase the plasma concentration of the latter. Overdose Overdose – the excess of the recommended dose, so it is typically not observed when taking recommended doses. In case of exceeding the recommended doses may cause the following symptoms: nausea, vomiting, abdominal pain, diarrhea, pruritus, metallic taste, ataxia, dizziness, paresthesia, seizures, leukopenia, dark urine staining. Treatment: symptomatic and supportive therapy, an accidental admission vnutr- gastric lavage. The drugs Group: Antimicrobial and protivoprotozoynoe means. Pharmacodynamics: Metronidazole relates to 5-nitroimidazole and is a drug with a bactericidal action type that exhibits tropism for deoxyribonucleic acid. The mechanism of action is in the biochemical reduction of 5-nitro group of metronidazole intracellular transport proteins of anaerobic microorganisms and protozoa. The recovered 5-nitro group of metronidazole is reacted with deoxyribonucleic acid microorganism cells by inhibiting synthesis of nucleic acids, which leads to the death of the bacteria. It is active against protozoa: Trichomonas vaginalis, Giardia lamblia, Entamoeba histolytica, and facultative anaerobes Bacteroides spp. (Including Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus), Fusobacterium spp., Veillonella spp., Prevotella spp. (Prevotella bivia, Prevotella buccae, Prevotella disiens) and some gram-positive obligate (Clostridium spp.) And optional (Eubacterium spp, Peptococcus spp, Peptostreptococcus spp, Mobiluncus spp….) Anaerobes and facultative aerobes – Gardnerella vaginalis. Insensitive to metronidazole aerobic microorganisms but in the presence of mixed flora (aerobes and anaerobes) metronidazole acts synergistically with antibiotics effective against common aerobes. Pharmacokinetics: The bioavailability of metronidazole in the intravaginal administration was 56%. It passes into breast milk and most tissues, crosses the placental and blood-brain barriers. Less than 20% bound to plasma proteins. It is metabolized in the liver by hydroxylation, oxidation and coupling with glucuronic acid. Activity of the main metabolite (2-oximetronidazole) is 30% of the activity of the parent compound. TA max costavlyaet 6-12 h half-life of metronidazole is about 8 hours excreted by the kidneys -.. 40-70%, mainly as metabolites (approximately 20% of the dose in unmodified form). Pregnancy and lactation The drug is contraindicated in the I trimester of pregnancy (crosses the placenta), hereinafter should be used only if the potential benefit to the mother outweighs the potential risk to the fetus. Metronidazole passes into breast milk, however breastfeeding during dosing should be canceled. Resuming breastfeeding may not earlier than 48 hours after drug application. Conditions of supply of pharmacies by prescription. Side effects Local side effects include itching, burning, pain and irritation in the vagina; thick white, mucus from the vagina odorless or low-odor; frequent urination; development of vaginal candidiasis after discontinuation of the drug; burning sensation or irritation of the penis in the sexual partner. On the part of the gastrointestinal tract: nausea, vomiting, change in taste, including a “metallic taste”, dry mouth, decreased appetite, abdominal cramping, constipation or diarrhea. From the nervous system: headache, dizziness. From hemopoiesis system: leukopenia or leukocytosis. Allergic reactions: rash, itching, skin rash. In rare cases, incontinence can be observed staining in the red-brown color, due to the presence of water-soluble pigment formed from the metabolism of metronidazole. Cautions In applying the drug is recommended to abstain from sexual intercourse. When vaginitis induced by Trichomonas vaginalis, to the simultaneous treatment of the sexual partner metronidazole for ingestion. In the case of the drug in conjunction with metronidazole for oral administration, especially when repeated course, necessary to monitor patterns of peripheral blood (risk of leukopenia). In the period of treatment is contraindicated intake of ethanol, it is possible intolerance and development disulfiramopodobnyh reactions: abdominal pain, spastic nature, nausea, vomiting, headache, a sudden rush of blood to the face. In the application of metronidazole can be false-positive test results Nelson (metronidazole can be immobilized Treponema). The presence in the history of leukopenia associated with influenza or other viral infections, is not a contraindication for the use of the drug. Effects on ability to drive vehicles and management of potentially dangerous machinery: should pay attention to the drivers of vehicles and persons operating other potentially dangerous machinery, the possibility of dizziness, associated with the use of the drug. Storage conditions in a dry, dark place at a temperature from 15 to 25 C. Keep out of reach of children. Dosing and dose Intravaginal adults. Trichomonas vaginitis: 1 suppository per day, immediately before bedtime for 7-10 days in combination with taking the drug metronidazole tablets. Nonspecific vaginitis, bacterial vaginosis: 1 suppository daily, immediately before bedtime for 7-10 days, if necessary in conjunction with administration of the drug metronidazole tablets. Treatment should not last more than 10 days and recur more often than 2-3 times a year. Pre-releasing suppository of contour packaging with scissors (to cut the film along the contour of a suppository), put it deep into the vagina. Info appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist 1 suppository daily, immediately before bedtime for 7-10 days, if necessary in conjunction with administration of the drug metronidazole tablets. Treatment should not last more than 10 days and recur more often than 2-3 times a year. Pre-releasing suppository of contour packaging with scissors (to cut the film along the contour of a suppository), put it deep into the vagina. Info appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist 1 suppository daily, immediately before bedtime for 7-10 days, if necessary in conjunction with administration of the drug metronidazole tablets. Treatment should not last more than 10 days and recur more often than 2-3 times a year. Pre-releasing suppository of contour packaging with scissors (to cut the film along the contour of a suppository), put it deep into the vagina. Info appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist Pre-releasing suppository of contour packaging with scissors (to cut the film along the contour of a suppository), put it deep into the vagina. Info appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist Pre-releasing suppository of contour packaging with scissors (to cut the film along the contour of a suppository), put it deep into the vagina. Info appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

AVEKSIMA

Use

infection

Release Form

rectal suppositories

Active ingredients

metronidazole

Dosage

500 mg

Amount in a package

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