Metromikon suppositories neo-vaginas. 500mg + 100mg 14 pieces

$76.00

Metromikon suppositories neo-vaginas. 500mg + 100mg 14 pieces

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Description

Composition Active substance 1 suppository contains: Metronidazole 500 mg, 100 mg miconazole nitrate ;. Excipients: semi-synthetic glycerides (Suppotsir AM) – sufficient quantity to produce 2000 mg of suppository mass. Description: White or white with a yellowish tinge torpedo-shaped suppositories. On the cut tolerance of air core or funnel-shaped depressions. Product form: Vaginal suppositories containing 500 mg of metronidazole mikonazola nitrate and 100 mg. 7 suppositories in blisters of PVC / PE film. 2 blisters together with instructions for use in a cardboard pack. Hypersensitivity to the drug or other nitroimidazole derivatives, I trimester of pregnancy, lactation, children under 18 years old; virgins. Precautions prescribed for liver and kidney failure, porphyria, and hematopoiesis tackle diseases of the peripheral and central nervous system, diabetes, disturbances of the microcirculation, pregnancy (II and III trimester). Dosage 500 mg + 100 mg Indications Vaginal infections: vaginal candidiasis; Trichomonas vaginitis and vulvovaginitis, bacterial vaginosis; Mixed vaginal infection. Interaction with other drugs in connection with a hit of metronidazole into the systemic circulation can mark following the coupling reaction while the use of certain substances: Oral anticoagulants: enhanced effect of indirect anticoagulants. Disulfiram: there may be violations of the central nervous system (mental reactions); Metronidazole should not be given to patients, who have taken disulfiram within the past 2 weeks; Phenytoin: increased phenytoin concentration in blood, and the concentration of metronidazole in the blood decreases. of lithium drugs: there may be increasing their toxicity. Phenobarbital: decreases the concentration of metronidazole in the blood. Cimetidine: may increase the concentration of metronidazole in blood. Astemizole and terfenadine: metronidazole and miconazole inhibit the metabolism of drugs and increase the concentration in plasma. Ethanol: metronidazole interaction with ethanol causes disulfiramopodobnye reaction. Overdosing Under the recommended dose, due to the low absorption of drug overdose cases not identified. Possible symptoms: nausea, vomiting, abdominal pain, diarrhea, itching, a metallic taste in the mouth, ataxia, dizziness, paresthesia, peripheral neuropathy (with prolonged use at high doses), seizures, leukopenia, dark urine staining (due to an overdose of metronidazole). Symptoms of an overdose of miconazole have been identified. Treatment: symptomatic and supportive therapy, in case of accidental ingestion – gastric lavage. Pharmacological action Pharmacological group: The antimicrobial agent combined (protivoprotozoynoe antimicrobial and antifungal agent +). Pharmacological properties: Metromikon-Neo – combined formulation with antiprotozoal, antifungal and antibacterial activity. It contains metronidazole and miconazole. Pharmacodynamics: Metronidazole belongs to the 5-nitroimidazole, and is a drug with bactericidal mode of action, exhibiting tropism (ability interaction) to deoxyribonucleic acid. The mechanism of action is in the biochemical reduction of 5-nitro group of metronidazole intracellular transport proteins of anaerobic microorganisms and protozoa. The recovered 5-nitro group of metronidazole is reacted with deoxyribonucleic acid microorganism cells by inhibiting synthesis of nucleic acids, which leads to the death of the bacteria. It is active against protozoa: Trichomonas vaginalis, Entamoeba histolytica, and obligate anaerobic bacteria: gramotritsatelnyh- Bacteroides spp. (Including Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus), Fusobacterium spp., Veillonella spp., Prevotella spp. (Prevotella bivia, Prevotella buccae, Prevotella disiens), Gram-positive – Clostridium spp, Eubacterium spp, Peptococcus spp, Peptostreptococcus spp, Mobiluncus spp….. and facultative anaerobes – Gardnerella vaginalis. Insensitive to metronidazole aerobic microorganisms but in the presence of mixed flora (aerobes and anaerobes) metronidazole acts synergistically with antibiotics effective against common aerobes. Miconazole is an antifungal agent, an azole derivative. When intravaginal application is active mainly against Candida albicans. Fungicidal and fungistatic effect is caused by inhibition of miconazole ergosterol biosynthesis membranes and plasma membranes of fungi, and the change in the lipid composition of the cell wall permeability, causing destruction of the fungus cells. Pharmacokinetics: Compared with oral bioavailability of metronidazole in the intravaginal administration was 20%. Metronidazole is metabolized in the liver. Hydroxy metabolites are active. The half-life of metronidazole is 6 – 11 hours, About 20% of the dose is excreted unchanged in the urine.. The intravaginal administration of miconazole absorbed slightly in the plasma is not defined. Pregnancy and lactation The appointment of the drug is contraindicated in the I trimester of pregnancy. Application in II and III trimester of pregnancy is possible only if the potential benefit to the mother outweighs the potential risk to the fetus. If necessary, the appointment during lactation, breast-feeding should be discontinued, since metronidazole passes into breast milk. Breast feeding may be resumed after 24-48 h after treatment. Conditions of supply of pharmacies on prescription. Side effects Local reactions: burning, itching, irritation of the vaginal mucosa and increased swelling. Due to inflammation of the vaginal mucosa at vaginitis irritation may be exacerbated after a first administration of a suppository, or by the third day of treatment. These complications rapidly disappear after cessation of treatment. On the part of the gastrointestinal tract: pain or cramping in the abdomen, “metallic” taste, dry mouth, constipation, diarrhea, loss of appetite, nausea, vomiting. From the nervous system: headache, motor disorders (ataxia), dizziness, psycho-emotional disorders, convulsions. From hemopoiesis system: a leukopenia. Allergic reactions: skin rash, including a rash. Cautions In applying the drug should refrain from sexual intercourse. In order to avoid reinfection necessary simultaneous treatment of the sexual partner. In the case of Trichomonas vaginitis to the simultaneous treatment of the sexual partner metronidazole for ingestion. During treatment and for at least 24-48 hours after treatment should avoid taking ethanol (available intolerance ethanol). Not simultaneous application of the drug is recommended with contraceptive diaphragms and condoms made of rubber or latex (perhaps interaction with suppository base). If a strong stimulation of the vaginal drug treatment should be discontinued. Suppositories should only be applied vaginally, can not be swallowed or applied in another way. In the case of the drug in conjunction with metronidazole for oral administration, especially when repeated course, necessary to monitor patterns of peripheral blood (risk of leukopenia). Effects on ability to drive vehicles and management of potentially dangerous machinery: It is recommended to be careful, as a possible negative effect on the ability to drive vehicles and management of complex mechanisms can not be ruled out. When side effects on the central nervous system should refrain from car driving and working with potentially dangerous machinery. Storage conditions in a dry dark place at a temperature of from 15 to 25 ° C. Keep out of reach of children. Dosing and dose Intravaginal. Acute vaginitis, bacterial vaginosis: 1 suppository morning and at night for 7 consecutive days. Chronic vaginitis: 1 suppository 1 time a day, just before bedtime, for 14 consecutive days. Often recurrent vaginitis or in the absence of positive clinical dynamics in the treatment of other methods: 1 suppository morning and night for 14 days. Pre-releasing suppository of contour packaging with scissors (to cut the film along the contour of a suppository), put it deep into the vagina. Info appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist Often recurrent vaginitis or in the absence of positive clinical dynamics in the treatment of other methods: 1 suppository morning and night for 14 days. Pre-releasing suppository of contour packaging with scissors (to cut the film along the contour of a suppository), put it deep into the vagina. Info appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist Often recurrent vaginitis or in the absence of positive clinical dynamics in the treatment of other methods: 1 suppository morning and night for 14 days. Pre-releasing suppository of contour packaging with scissors (to cut the film along the contour of a suppository), put it deep into the vagina. Info appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist There are contraindications. You need to read the manual or consult with a specialist There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

AVEKSIMA

Use

infection

Release Form

rectal suppositories

Active ingredients

+ metronidazole, miconazole

Dosage

500 mg + 100 mg

Amount in a package

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